Primary Angiosarcoma of the Gastrointestinal Tract: A Systematic Review of the Literature

Schizas, Dimitrios; Mastoraki, Aikaterini; Giannakodimos, Ilias; Giannakodimos, Alexios; Ziogou, Afroditi; Katsaros, Ioannis; Frountzas, Maximos; Koutelidakis, Ioannis; Vassiliu, Pantelis; Pikoulis, Emmanouil

doi:10.1080/08941939.2020.1853283

Cited by 9 publications

(13 citation statements)

References 55 publications

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“…Diagnosis is challenging because their clinical presentation is atypical. However, complaints of patients mainly include abdominal pain and gastrointestinal bleeding (Schizas et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…The estimated incidence of vascular sarcoma is 0.01 per 100,000 people per year in Europe (Gatta et al, 2017). Schizas, et al performed a systematic review in December 2020 and found 110 cases of primary gastro-intestinal angiosarcoma (Schizas et al, 2022). They state that primary gastro-intestinal angiosarcomas are extremely rare, and distant dissemination is infrequent (Allison et al, 2004;Sadhu et al, 2010;Sherid et al, 2013;Mokutani et al, 2017).…”

Section: Answermentioning

confidence: 99%

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Abdominal Pain in A 82-Year-Old Male: A Case Report

Opperman¹,

Bogt²

2022

FMCR

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Angiosarcoma is a rare malignancy which arises from the inner lining of blood vessels and lymph vessels. Patients most frequently present with cutaneous lesions. Vascular sarcomas are clinically aggressive and have a poor 5- year survival rate of approximately 20-35%. Primary gastro-intestinal angiosarcomas are extremely rare, and distant dissemination is infrequent. Diagnosis is challenging because their clinical presentation is atypical. In this short report, we present an uncommon case of an angiosarcoma located in the cecum of a 82-year-old male. The patient was treated with surgical resection, however he passed away four weeks later. This report highlights the recommended treatment, endoscopic findings and clinical symptoms

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Section: Discussionmentioning

confidence: 99%

Section: Answermentioning

confidence: 99%

Abdominal Pain in A 82-Year-Old Male: A Case Report

Opperman¹,

Bogt²

2022

FMCR

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“…7 Within the GI tract, the small intestine is the most frequent location. 2 Still, it is hard to distinguish between primary and metastatic angiosarcoma. 4 A retrospective study of 66 cases of angiosarcoma of the small intestine showed that angiosarcoma of cutaneous or aortic origin often metastasized to the small intestine.…”

Section: Discussionmentioning

confidence: 99%

“…It mainly occurs in the skin, breast, heart and liver but it can also be found in any soft tissue structure or viscus. 1 It rarely involves the gastrointestinal (GI) 2 tract and only individual case reports and small series have been reported in the literature. 2 It can be both primary, seated in the GI tract, or secondary to the direct extension of a retroperitoneal tumor.…”

Section: Introductionmentioning

confidence: 99%

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Case Report: Severe gastrointestinal bleeding revealing metastatic multifocal gastrointestinal angiosarcoma

Chabbouh¹,

Ayoun²,

Khsiba³

et al. 2022

F1000Res

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Background: Angiosarcoma is a rare soft-tissue sarcoma that can arise in any soft-tissue structure or viscera. Only individual case reports and small series of gastrointestinal angiosarcoma have been reported in the literature. In this paper, we report the first African case of small intestine epithelioid angiosarcoma. Case report: Here, we present the case of a 66-year-old man who presented with melena and anemia. Physical examination showed the presence of two subcutaneous masses on the right and left flanks. Esophagogastroduodenoscopy, duodenoscopy and jejunoscopy revealed multiple purpuric and hemorrhagic nodules and masses, some of which were bleeding. Pathological study of the ampullary formation and of a subcutaneous nodule concluded to the diagnosis of epithelioid angiosarcoma. Blood transfusions and interventional endoscopy by argan plasma coagulation were required due to a continued drop in hemoglobin. A drop in hemoglobin persisted and the patient died within 10 days. Conclusions: Angiosarcoma has a very poor prognosis due to delayed prognosis and insufficient therapeutic management. Interventional endoscopy to control bleeding can be considered in localized forms. Chemotherapy may help to prolong survival in metastatic and disseminated angiosarcoma. Further studies should be conducted to improve the prognosis.

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