Primary Angiosarcoma of the Brain: Case Report

Antoniadis, Christos; Selviaridis, Panagiotis; Zaramboukas, Thomas; Fountzilas, George

doi:10.1097/00006123-199603000-00033

Cited by 19 publications

(34 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the surgery the blood loss can be substantial, and early recurrence after surgery with or without radiation therapy can occur. These characteristics argue for aggressive multimodal therapy, as described by Antoniadis et al 3 . Given the vascularity of the tumor, intraoperative blood loss might be diminished by circumferentially dissecting around the tumor, dividing the traversing vascular supply, rather than intratumorally debulking 3 .…”

Section: Discussionmentioning

confidence: 97%

“…Microscopically, angiosarcomas are endothelial neoplasms forming irregular vascular spaces 3,4 . Immunocytochemistry and electron microscopy are always beneficial in differentiating angiosarcoma from meningeal hemangiopericytoma (angioblastic meningioma) 3,13,17 .…”

Section: Discussionmentioning

confidence: 99%

“…Immunocytochemistry and electron microscopy are always beneficial in differentiating angiosarcoma from meningeal hemangiopericytoma (angioblastic meningioma) 3,13,17 . The specific pathological criterion used to characterize angiosarcoma is the diffuse posivity of tumor cells for .actor VIII and lectin ULEX 2,9 , whereas in hemangiopericytoma, it is the endothelial cells that are positive for these factors 3,5,18 .…”

Section: Discussionmentioning

confidence: 99%

“…The initial approach in patients with brain angiosarcomas should always be the surgical removal of the tumors 3 . During the surgery the blood loss can be substantial, and early recurrence after surgery with or without radiation therapy can occur.…”

Section: Discussionmentioning

confidence: 99%

“…This tumor mainly occurs in the head and face, liver, skin and other soft tissues and comprises lower than 1% of all sarcomas [3][4][5][6] . Cases of primary or secondary angiosarcomas in the central nervous system (CNS) are exceedingly rare malignancies and have previously been reported only exceptionally [1][2][3][4][7][8][9] . We present a case of cerebral metastasis from angiosarcoma of the heart manifested by intracerebral hemorrhage.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

Gallo

Dini

Saraiva

et al. 2001

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-The purpose of this article is to describe the clinical and pathological features of metastatic angiosarcoma in the central nervous system. Only a few cases of cerebral metastasis from angiosarcoma of the heart have been recorded in the literature; particulary related to intracerebral hemorrhage. A case of secondary cerebral angiosarcoma of the heart in a 33 years old man is presented. The initial symptoms were headache, vomiting, lethargy and aphasia. There was a mass in the left temporal lobe with hemorrhage and edema on the computerized tomography (CT). After 24 hours the neurological status worsened and another CT scan showed rebleeding on the tumor area. He underwent an emergency craniotomy but died two days after. Considering the longer survival of sarcoma patients with new modalities of treatment, the incidence of brain metastasis may increase, demanding a bether preventive and more aggressive approach. Besides, due to the hemorrhagic nature of such lesions, we suggest the imediate surgery to prevent a fast and lethal evolution because rebleeding.KEY WORDS: brain neoplasm, metastasis, angiosarcoma, heart tumor.Hemorragia em metástase cerebral de angiossarcoma cardíaco: relato de caso RESUMO -O propósito deste artigo é descrever os achados clínicos e patológicos das metástases de angiossarcoma no sistema nervoso central. Apenas poucos casos de metástases cerebrais de angiossarcoma cardíaco foram relatados na literatura, menos ainda relacionados a hemorragia intracerebral. Relatamos o caso de um tumor cerebral secundário a angiossarcoma cardíaco em um paciente masculino de 33 anos. Os sintomas iniciais foram: cefaléia, vômitos, letargia e afasia. A tomografia computadorizada mostrou massa no lobo temporal esquerdo associada a hemorragia e edema. Após 24 horas houve piora do estado neurológico e nova tomografia demonstrou ressangramento no leito tumoral. .oi submetido a uma craniotomia de urgência mas faleceu dois dias após. Considerando a longa sobrevida dos pacientes com sarcoma devido às novas modalidades terapêuticas, poderá aumentar a incidência de metástases cerebrais, necessitando, assim, de melhores métodos preventivos e abordagens cirúrgicas agressivas. PALAVRAS-CHAVES: neoplasia cerebral, metástase, angiossarcoma, tumor cardíaco.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

Gallo

Dini

Saraiva

et al. 2001

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

Primary temporal bone angiosarcoma: a case report

et al. 2005

View full text Add to dashboard Cite

SummaryWe present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a tender swelling above the mastoid. Cranial imaging studies showed a 7 × 5 × 4 cm hypervascularized mass located in the left middle fossa with lysis of the temporal bone and extension to the subcutis. After the baby was delivered by caesarean section, the patient entered the oncology protocol. Selective embolization of the feeding vessels was followed by gross total surgical resection using a combined supra-and infra-tentorial approach. Pathological findings were those of a poorly differentiated, highly malignant sarcoma with a large epitheloid component and immunohistochemical evidence of endothelial differentiation (CD31, Factor VIII related antigen, CD34), consistent with an angiosarcoma with epitheloid features. No extra-cranial tumor was found after extensive staging. The patient received adjuvant radiotherapy followed by a course of chemotherapy consisting of 6 cycles of paclitaxel. At 15 months follow-up, she developed multiple distant metastasis to a left postauricular lymph node and to the lungs and ribs. The patient was given a second line chemotherapy using doxorubicine and ifosfamide. Despite an initial good response, she died with metastatic disease 26 months after diagnosis. We present a rare case of primary temporal bone angiosarcoma and report our experience with a multimode therapeutic approach combining surgery, radiotherapy and chemotherapy.

show abstract