Primary angioplasty versus systemic thrombolysis in anterior myocardial infarction

Garcı́a, Eulogio; Elı́zaga, Jaime; Pérez‐Castellano, Nicasio; Serrano, José Antonio; Soriano, Javier; Abeytua, Manuel; Botas, Javier; Rubio, Rafael; Sá, Esteban López de; López‐Sendón, José; Delcán, Juan L.

doi:10.1016/s0735-1097(98)00644-5

Cited by 118 publications

(47 citation statements)

References 27 publications

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“…The mean value of ventricular function of 49.5%±12% obtained prior to hospital discharge in the surviving patients means that this is a group with a favorable prognosis. These results are similar to the 48% reported by Garcia et al 39 and the 49% of the TIMI 2A study 20 , but are below the 53% reported by Gibbons 25 and the 56% of the TAMI study 48 . The mortality rate in the first year for those patients who survived free from events in the in-hospital phase was 2%.…”

Section: Discussionsupporting

confidence: 85%

“…To avoid the effect of colinearity, blood pressure was excluded from the model of multiple logistic regression, and, due to conceptual reasons, because survival was a criterion of success of the procedure, angiographic success was also excluded to avoid a confounding bias. These findings are supported by those of the PAMI study 23 , MITI study 29 , and the studies by Garcia et al 39 and Azmus 41 , which proved that advanced age was a variable independently associated with higher mortality. Functional class, as defined by the criteria of Killip-Kimbal at hospital admission, was the major determinant of worse in-hospital evolution.…”

Section: Discussionsupporting

confidence: 76%

“…The in-hospital mortality of 18.5% and the angiographic success of 78% are not in total accordance with the results reported in the literature, which range from 0% to 10% and from 73% to 98%, respectively [24][25][26][27][28][29]35,[37][38][39]41 . However, we should consider that this cohort assesses the patients in a global manner, without excluding the most severely ill ones with Killip III and IV functional classes, and that it uses a very strict criterion for the definition of success of a procedure, which is exclusively the obtainment of TIMI 3 flow, with residual stenosis lower than 50% in patients surviving an event.…”

Section: Discussionmentioning

confidence: 59%

“…These patients, who were excluded from or accounted only for a reduced part of the sample in most series and clinical trials [25][26]35,39,40 , constituted approximately 13% of our study's sample and directly contributed to the higher number of unsuccessful cases, mortality, and worse evolution.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of primary angioplasty in the treatment of acute myocardial infarction. Analysis of in-hospital and late outcomes in 135 consecutive cases

Leite

Krepsky

Gottschall

2001

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of primary angioplasty in the treatment of acute myocardial infarction. Analysis of in-hospital and late outcomes in 135 consecutive cases

Leite

Krepsky

Gottschall

2001

Arq. Bras. Cardiol.

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“…PTCA/Stents-Several studies have shown that PTCA is superior to thrombolysis for the treatment of acute MI (68)(69)(70). Primary stenting during acute MI is safe and is associated with better survival and lower restenosis rates when compared to PTCA (71).…”

Section: Acute St Elevation MImentioning

confidence: 99%

Update in Internal Medicine

López-Jiménez

Brito

Aude

et al. 2000

Archives of Medical Research

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More than 500,000 new medical articles are published every year and available time to keep updated is scarcer every day. Nowadays, the task of selecting useful, consistent, and relevant information for clinicians is a priority in many major medical journals. This review has the aim of gathering the results of the most important findings in clinical medicine in the last few years. It is focused on results from randomized clinical trials and well-designed observational research. Findings were included preferentially if they showed solid results, and we avoided as much as possible including only preliminary data, or results that included only non-clinical outcomes.Some of the most relevant findings reported here include the significant benefit of statins in patients with coronary artery disease even with mean cholesterol level. It also provides a substantial review of the most significant trials assessing the effectiveness of IIb/IIIa receptor blockers. In gastroenterology many advances have been made in the H. pylori eradication, and the finding that the cure of H. pylori infection may be followed by gastroesophageal reflux disease. Some new antivirals have shown encouraging results in patients with chronic hepatitis. In the infectious disease arena, the late breaking trials in anti-retroviral disease are discussed, as well as the new trends regarding antibiotic resistance. This review approaches also the role of leukotriene modifiers in the treatment of asthma and discusses the benefit of using methylprednisolone in patients with adult respiratory distress syndrome, among many other advances in internal medicine.

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Primary Percutaneous Coronary Intervention Compared With Fibrinolysis for Myocardial Infarction in Diabetes Mellitus

Timmer

Ottervanger²,

Boer³

et al. 2007

Arch Intern Med

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Background: There is growing evidence for a clinical benefit of primary percutaneous coronary intervention (PCI) compared with fibrinolysis; however, whether the treatment effect is consistent among patients with diabetes mellitus is unclear. We compared PCI with fibrinolysis for treatment of ST-segment elevation myocardial infarction in patients with diabetes mellitus.Methods: A pooled analysis of individual patient data from 19 trials comparing primary PCI with fibrinolysis for treatment of ST-segment elevation myocardial infarction was performed. Trials that enrolled at least 50 patients with ST-segment elevation myocardial infarction and randomized patients to receive either primary PCI or fibrinolysis were considered for inclusion in our study. Clinical end points were total deaths, recurrent infarction, death or nonfatal recurrent infarction, and stroke, measured 30 days after randomization.Results: Of 6315 patients, 877 (14%) had diabetes. Thirty-day mortality (9.4% vs 5.9%; PϽ.001) was higher Author Affiliations are listed at the end of this article. Group Information: The members of the Primary Coronary Angioplasty vs Thrombolysis-2 Trialists Collaborators Group are listed at the end of the article.

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Primary angioplasty versus systemic thrombolysis in anterior myocardial infarction

Abstract: In centers with an experienced and readily available interventional team, primary angioplasty is superior to t-PA for the treatment of anterior AMI.

Cited by 118 publications

References 27 publications

Effectiveness of primary angioplasty in the treatment of acute myocardial infarction. Analysis of in-hospital and late outcomes in 135 consecutive cases

Effectiveness of primary angioplasty in the treatment of acute myocardial infarction. Analysis of in-hospital and late outcomes in 135 consecutive cases

Update in Internal Medicine

Primary Percutaneous Coronary Intervention Compared With Fibrinolysis for Myocardial Infarction in Diabetes Mellitus

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