Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan

Abstract

The surveys provided valuable information on the epidemiology of SS including prevalence, disease type, extra-glandular involvement, satisfaction of diagnostic criteria sets and treatments used today in Japan.

Risk factors for primary Sjögren syndrome-associated interstitial lung disease

“…SS can occur alone as primary SS (pSS) or in association with other autoimmune diseases, such as rheumatoid arthritis or systemic lupus erythematosus, which is known as secondary SS (2). pSS is a heterogeneous disease characterized by a wide spectrum of presentations.…”

“…Risk factors for primary Sjögren syndrome-associated interstitial lung disease kidneys, small vasculature, and other endocrine glands, are often involved in pSS (2). The presentation of pSS may be significantly influenced by epidemiological characteristics, systemic involvement, or the immunological profile at diagnosis.…”

Effectiveness of abatacept for patients with Sjögren’s syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: ROSE (Rheumatoid Arthritis with Orencia Trial toward Sjögren’s syndrome Endocrinopathy) trial

“…SS is classified into primary SS, which is not associated with any other well-defined connective tissue disease (CTD), and secondary SS, which is associated with other well-defined CTD [1]. With regard to secondary SS, all-Japan survey on the epidemiology of SS showed previously that secondary SS was associated with rheumatoid arthritis (RA) in 38.7% of the cases, and systemic lupus erythematosus (SLE) in 22.2% [2]. These data highlight the clinical importance of secondary SS associated with RA.…”

Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study

“…Patients with RA have impaired hand function that compromises tooth brushing, and thus these disabilities may be associated with poor dental health and periodontitis. Twenty-eight percent of patients with RA reported having at least one sicca symptom [19], and RA was diagnosed in 39 % of Japanese patients with secondary Sjögren's syndrome [20]. Thus, periodontitis, difficulty with tooth brushing, and sicca syndrome may be associated with poor dental health in Japanese patients with RA, although further studies are needed to draw firm conclusions.…”