“…6 Chronic anemia-induced marrow hyperplasia in thalassemia results in some characteristic changes in the skeletal system, such as thinning of the cortical bone, medulla expansion, resorption of the cancellous bone, and generalized osteopenia (Figs. 1,3,4). 7 In over 85% of patients with EMH, liver, spleen, and lymph nodes serve as the secondary sites of the hematopoiesis, followed by the paraspinal space in 5% of patients and the retroperitoneum in less than 2% of patients.…”