Primary and recurrent serous borderline tumors during pregnancy: a case report and literature review

Matsumoto, Aya; Ito, Takuma; Hamaguchi, Fumika; Kasuga, Maya; Mikami, Takuma; Hino, M.; Yokoyama, Reiko; Yamamura, Shogo; Sakata, Harumi; Minamiguchi, Sachiko; Mandai, Masaki; Yoshida, Taiki

doi:10.1007/s13691-021-00471-5

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Firstly, FSS has been identified as a significant risk factor for serous BOT recurrence, occurring in 25.0-56.4% of patients who undergo FSS [ 17 ]. Additionally, instances of serous BOT associated with pregnancy have been reported in the literature [ 18 , 19 ]. For instance, Matsumoto et al [ 19 ] detailed a case of serous BOT diagnosed at seven weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, instances of serous BOT associated with pregnancy have been reported in the literature [ 18 , 19 ]. For instance, Matsumoto et al [ 19 ] detailed a case of serous BOT diagnosed at seven weeks of gestation. Although the patient remained recurrence-free for four years, the recurrent disease was diagnosed at 13 weeks of her subsequent pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Serous Borderline Tumor After Fertility-Sparing Surgery Following Twin Pregnancy and Resumption of Menstruation

Morita,

Matsushita,

Yabushita

et al. 2024

Cureus

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Gynecologic malignancies sometimes affect women before menopause. Aggressive treatments, such as surgery, chemotherapy, and/or radiotherapy, often lead to premature menopause. Hormone replacement therapy (HRT), typically used for managing menopause-associated health issues, may be limited by tumor sensitivity to estrogen. Here, we present a case of a 37-year-old woman seeking fertility, who was diagnosed with a serous borderline ovarian tumor (BOT). Fertility-preserving surgery and in-vitro fertilization resulted in a twin pregnancy. During a postpartum amenorrheic period, there was no recurrence. However, she experienced a rapid recurrence of the disease following the resumption of menstruation and underwent radical surgery. This rapid recurrence after menstruation resumed suggests potential estrogen sensitivity. Close postoperative monitoring has been ongoing without HRT.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrent Serous Borderline Tumor After Fertility-Sparing Surgery Following Twin Pregnancy and Resumption of Menstruation

Morita,

Matsushita,

Yabushita

et al. 2024

Cureus

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“…There are only small studies and single clinical cases for certain subtypes of epithelial ovarian cancer in pregnancy [20,21]. In the larger reviews that do exist, all subtypes of ovarian cancer are usually analyzed and discussed together [22][23][24][25][26]. With advances in surgical techniques and new medical treatment options, different subtypes of ovarian cancer, such as epithelial ovarian cancer with serous, mucinous, endometrioid, and clear cell subtypes; sex-cord ovarian cancer with granulosa cell tumors and Sertoli-Leydig cell tumors; and germ cell ovarian cancer with immature teratomas, dysgerminomas, yolk sac tumors, and embryonal cancer are treated differently and individually, especially during pregnancy [4,27].…”

Section: Introductionmentioning

confidence: 99%

High-Grade Serous Ovarian Cancer during Pregnancy: From Diagnosis to Treatment

Vivod,

Merlo,

Kovacevic

2024

Current Oncology

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Background: Due to the rarity of ovarian cancer diagnosed during pregnancy, the literature on the treatment of subtypes of epithelial ovarian cancer in pregnancy is sparse. The aim of our review was to analyze cases of high-grade serous ovarian cancer in pregnancy. Methods: The PubMed and Scopus databases were searched for relevant articles published in English between January 2000 and December 2023. The references of all the relevant reviews found were also checked to avoid omitting eligible studies. Information on the all retrieved cases was extracted and reviewed in detail. The most important detail was the subtype of high-grade serous ovarian cancer, which was referred to as serous adenocarcinoma (grade 2 or grade 3) in older cases. Results: We found eleven cases with relevant details of high-grade serous ovarian cancer diagnosed in pregnancy. Despite the small number of cases we found, our study demonstrated the importance of an accurate initial vaginal ultrasound at the first examination in pregnancy and the safety of diagnostic surgery and chemotherapy in pregnancy. Conclusions: There have not been long-term follow-ups of patients’ oncologic and obstetric outcomes. As patients should be comprehensively informed, more detailed case reports or series with longer follow-up periods are needed.

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Complex Ovarian Mass

Augustin

2023

Acute Abdomen During Pregnancy

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Primary and recurrent serous borderline tumors during pregnancy: a case report and literature review

Cited by 4 publications

References 26 publications

Recurrent Serous Borderline Tumor After Fertility-Sparing Surgery Following Twin Pregnancy and Resumption of Menstruation

Recurrent Serous Borderline Tumor After Fertility-Sparing Surgery Following Twin Pregnancy and Resumption of Menstruation

High-Grade Serous Ovarian Cancer during Pregnancy: From Diagnosis to Treatment

Complex Ovarian Mass

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