Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review

Yang, Runze; Isaacs, Albert M.; Cadieux, Magalie; Hirmer, Tomas J.; CreveCoeur, Travis S.; Lapointe, Andrew P.; Opoku-Darko, Michael; Premji, Zahra; Riva-Cambrin, Jay; Gallagher, Clare

doi:10.1007/s00381-021-05098-8

Cited by 2 publications

(2 citation statements)

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“…According to a single-center retrospective study by Cheng et al [ 22 ], the extent of surgical resection did not have any significance, but radiotherapy accompanied with postoperative chemotherapy was the major prognostic factor for longer survival in adult GB patients. However, the previous study reported that gross-total resection followed by radiotherapy had beneficial effects on the overall outcome of PSC GB in the pediatric age group[ 23 , 24 ]. More effective and targeted therapies need specific investigation in the future for helping patients with unique gene mutations achieve better prognosis[ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Atypical imaging features of the primary spinal cord glioblastoma: A case report

Li¹,

Chen²,

Li³

et al. 2022

WJCC

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BACKGROUND Primary spinal cord (PSC) glioblastoma (GB) is an extremely rare but fatal primary tumor of the central nervous system and associated with a poor prognosis. While typical tumor imaging features are generally easy to recognize, glioblastoma multiforme can have a wide range of imaging findings. Atypical GB is often misdiagnosed, which usually delays the optimal time for treatment. In this article, we discuss a clinical case of pathologically confirmed PSC GB under the guise of benign tumor imaging findings, as well as the most recent literature pertaining to PSC GB. CASE SUMMARY A 70-year-old female complained of limb weakness lasting more than 20 d. Irregular masses were observed inside and outside the left foramina of the spinal canal at C7-T1 on medical imaging. Based on the imaging features, radiologists diagnosed the patient with schwannoma. Tumor resection was performed under general anesthesia. The final histopathological findings revealed a final diagnosis of PSC GB, world health organization Grade IV. The patient subsequently underwent a 4-wk course of radiotherapy (60 Gy in 20 fractions) combined with temozolomide chemotherapy. The patient was alive at the time of submission of this manuscript. CONCLUSION Atypical GB presented unusual imaging findings, which led to misdiagnosis. Therefore, a complete recognition of imaging signs may facilitate early accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Atypical imaging features of the primary spinal cord glioblastoma: A case report

Li¹,

Chen²,

Li³

et al. 2022

WJCC

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“…Estudo sobre glioblastoma multiforme espinhal pediátrico indicou que o impacto da quimioterapia dependia da idade do paciente de tal forma que, quanto mais nova a criança, maiores eram os benefícios do tratamento. Além disso, conforme reduziam os benefícios do tratamento com quimioterápicos perante o grupo sem quimioterapia, houve, por volta dos 14 anos, uma interseção entre as sobrevidas, evidenciando que em torno dessa idade não havia diferença entre o plano escolhido (YANG et al, 2021).…”

Section: Tratamento Em Criançasunclassified

Glioblastoma: Novas Perspectivas De Tratamento – Uma Revisão Da Literatura

NEVES¹,

BELATO²,

SANTOS³

et al. 2023

Oncologia E Hematologia - Edição III

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Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review

Cited by 2 publications

References 46 publications

Atypical imaging features of the primary spinal cord glioblastoma: A case report

Atypical imaging features of the primary spinal cord glioblastoma: A case report

Glioblastoma: Novas Perspectivas De Tratamento – Uma Revisão Da Literatura

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