Primary Amyloidosis of the Renal Pelvis

Gardner, Kenneth D.; Castellino, R A; Kempson, Richard L.; Young, Brandt; Stamey, Thomas A.

doi:10.1056/nejm197105272842107

Cited by 27 publications

(2 citation statements)

References 9 publications

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“…Primary amyloidosis can occur anywhere along the urinary tract and has been reported in the kidney, renal pelvis, ureters, penis and even in the seminal vesicles (5)(6)(7)(8). While the etiology of amyloidosis is unknown, several theories suggest a chronic monoclonal inflammatory response or an immunologic mechanism (9).…”

Section: Discussionmentioning

confidence: 99%

Amyloidoma of the Bladder Mimicking a Bladder Tumor

2020

GMJ

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Primary amyloidosis of the bladder is a rare disease reported in about 200 cases in the literature (1). Generally, this patients are admitted to the hospital with painless gross hematuria and lower urinary tract symptoms. Especially, symptomatic, radiological and cystoscopic findings of bladder amylodidosis and bladder cancer are similar. Neoplasia, hemorragic cystitis and lyphoma should be considered in differential diagnosis. Pathological diagnosis is imperative for the definitive diagnosis. Its pathophysiology is unknown, the prognosis is usually good and there is no specific treatment. Herein, we present the diagnosis and treatment of bladder amyloidosis, which is rare and mimics bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Amyloidoma of the Bladder Mimicking a Bladder Tumor

2020

GMJ

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“…Selten finden sich isolierte Amyloidtumoren im Knochen, wo sie als Folge eines solitären Plasmozytoms [150] entstehen, ohne dass daraus eine generalisierte Amyloidose werden muss. Selten liegen sie auch in der Harnblase [117] oder im Nierenbecken [56], in der Mamma [118], in der Parotis [215] oder in einem peripheren Nerv [158]. Auch in der Cervix uteri können Amyloidtumoren sich entwickeln [223], wobei diese dann aber von lokalem Amyloid zu trennen sind, das als Keratin-Abkömmling sich in einem Plattenepithelkarzinom entwickeln kann [71].…”

Section: Lokales Tumorartiges Amyloidunclassified

Interdisziplinäre Leitlinien zur Diagnostik und Therapie der extrazerebralen Amyloidosen

Röcken

Ernst²,

Hund³

et al. 2006

Dtsch med Wochenschr

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Within the past 10 years, a new range of knowledge has been achieved in the field of amyloidosis, especially with regard to pathogenesis, diagnosis and therapy. Amyloidosis leads to variable and distinct symptoms and is caused by different underlying conditions. Some amyloidoses are acquired secondary to a chronic condition; others are caused by genetic mutations. Amyloid and amyloidosis occur more frequently than they are perceived. Among the frequent localized forms are the cerebral amyloidosis linked to Alzheimer disease (AD) and the pancreatic amyloidosis linked to diabetes mellitus. Among the most frequent systemic (extracerebral) forms is AL amyloidosis, which often has a poor prognosis and if untreated can rapidly lead to death. Systemic amyloidosis that happen at infancy are mainly AA amyloidosis that can progress to death already at early or at middle adulthood. Amyloidosis can be treated but therapeutic success significantly depends upon early diagnosis and proper classification of the amyloid type. It is mandatory that differential diagnosis demonstrate the presence of amyloid and clearly identify the type of the disease. Development of methods and techniques have contributed to improvements in the diagnosis and treatment. Early diagnosis and proper classification of amyloid is decisive for therapeutic options and upon them depend quality of life and mortality. The therapeutic spectrum is various and includes organ transplantation, chemotherapy, and anti-inflammatory strategies. Gene therapy and biological active substances have to be considered in the near future.

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