Primary alveolar rhabdomyosarcoma of the brain with long-term survival

Khalatbari, Mahmoud Reza; Hamidi, Mehrdokht; Moharamzad, Yashar

doi:10.1007/s11060-013-1204-5

Cited by 10 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multimodality approach including total surgical resection with subsequent chemotherapy and radiotherapy is regarded as the best course of treatment. [ 9 10 ]…”

Section: Discussionmentioning

confidence: 99%

Intracranial rhabdomyosarcoma of the cerebellopontine angle in a 6-year-old child: A case report

et al. 2020

View full text Add to dashboard Cite

A BSTRACT Rhabdomyosarcoma (RMS) is the most common soft-tissue malignancy in children under 15 years of age. Approximately, 35% of RMS cases originate from the head and neck region. Among various sites in the head and neck region, intracranial extension is more likely to occur with parameningeal tumors, which is also considered an unfavorable prognostic factor in children with RMS. About 20% of RMS occurs in a parameningeal site. Intracranial RMS are rare tumors that usually arise from parameningeal sites or metastasis from an extracranial site. Primary intracranial types are even rarer, with only 50 reported cases of primary intracranial RMS in the literature. Hereby, we report the case of a 6-year-old boy who presented with clinical and radiologic features of a cerebellopontine angle lesion, which turned out to be a RMS.

show abstract

“…Multimodality approach including total surgical resection with subsequent chemotherapy and radiotherapy is regarded as the best course of treatment. [ 9 10 ]…”

Section: Discussionmentioning

confidence: 99%

Intracranial rhabdomyosarcoma of the cerebellopontine angle in a 6-year-old child: A case report

et al. 2020

View full text Add to dashboard Cite

show abstract

“…8,18 There has been no report of primary pineal rhabdomyosarcoma, but 2 cases of secondary rhabdomyosarcoma arising in a pineal teratoma have been described. 5,15 In the present case, mixed GCT or malignant transformation of a teratoma associated with a rhabdomyosarcomatous component was strongly considered as the differential diagnosis after the first operation.…”

Section: Discussionmentioning

confidence: 99%

“…There are 8 previous cases (Table 1) of primary intracranial rhabdomyosarcoma with long-term survival > 24 months. 1,4,6,8,12,13,19 Postoperative radiation and chemotherapy with multiple anticancer drugs were administered in all but 1 patient, who received only radiation postoperatively. The treatment strategy has not been established because this tumor is too rare to conduct clinical study for treatment; however, results in these documented cases suggest the efficacy of multimodal treatment for primary intracranial rhabdomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,7,20 Primary intracranial rhabdomyosarcoma is extremely rare, and only 48 cases have been reported. 8,18 Most, however, were reported in the 20th century, and few patients underwent intensive treatment with chemotherapy and radiotherapy. Therefore, the efficacy of chemotherapy and radiotherapy for primary intracranial rhabdomyosarcoma is unknown, and the treatment strategy has not been established.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Primary pineal rhabdomyosarcoma successfully treated by high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation: case report

Ishi¹,

Yamaguchi²,

Iguchi

et al. 2016

PED

View full text Add to dashboard Cite

Primary intracranial rhabdomyosarcoma is quite rare, and its prognosis is poor compared with that for rhabdomyosarcoma in other organs. The authors present a case of pineal rhabdomyosarcoma successfully managed with multimodal therapy including surgery, chemotherapy, radiation, and high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (HDC/APBSCT). An 8-year-old girl presenting with headache and nausea was referred to the authors' institution. Computed tomography and MRI revealed a pineal tumor associated with obstructive hydrocephalus. Subsequently, an emergent endoscopic tumor biopsy and third ventriculostomy were performed. The patient's symptoms immediately improved. The most likely pathological diagnosis was embryonal rhabdomyosarcoma. Chemotherapy with etoposide, cyclophosphamide, cisplatin, pirarubicin, ifosfamide, actinomycin D, and vincristine was followed by a second-look operation and whole-brain and craniospinal radiation. Because the intraoperative findings and pathological examination of the second operation suggested a definitive diagnosis of rhabdomyosarcoma and the presence of viable residual tumor cells, HDC with etoposide and melphalan was followed by APBSCT. The patient was discharged from the hospital without residual tumor or any neurological deficit. No recurrence was observed at 30 months. This is the first case of primary pineal rhabdomyosarcoma treated with HDC/APBSCT. Although the efficacy of HDC/APBSCT for rhabdomyosarcoma has not been established, the prognosis of primary intracranial rhabdomyosarcoma treated with conventional treatment is quite poor. High-dose chemotherapy followed by APBSCT may contribute to a better prognosis for primary intracranial rhabdomyosarcoma.

show abstract

“…[278] Frontal lobe and cerebellum are the commonest reported sites of intracranial RMS. [34] Common pineal region tumors include pineal parenchymal tumors and the germ cell tumors,[1] RMS has been reported only three times at this site. [2910]…”

Section: Discussionmentioning

confidence: 99%

Primary pineal rhabdomyosarcoma: A rare case

2019

View full text Add to dashboard Cite

Primary pineal rhabdomyosarcoma (RMS) is extremely rare, and only three cases have been reported so far. Here, we report a case of 12-year-old male who presented with complaints of diplopia and diminution of vision since 15 days. He also had left-sided facial paresis. Magnetic resonance imaging brain revealed a space-occupying lesion in the region of pineal gland. The patient underwent midline suboccipital craniectomy with excision of tumor. Microscopic examination revealed a highly cellular tumor with areas showing small round cells admixed with cells having abundant eosinophilic cytoplasm resembling rhabdomyoblasts and multinucleated giant cells. Differential diagnoses of pineal anlage tumor and primary RMS were considered. The tumor cells were positive for desmin while being negative for synaptophysin and glial fibrillary acidic protein. Myogenin was used to confirm the diagnosis of RMS, which showed focal nuclear positivity. INI1 was retained. All the markers for germ cell tumors were negative.

show abstract

Primary alveolar rhabdomyosarcoma of the brain with long-term survival

Cited by 10 publications

References 5 publications

Intracranial rhabdomyosarcoma of the cerebellopontine angle in a 6-year-old child: A case report

Intracranial rhabdomyosarcoma of the cerebellopontine angle in a 6-year-old child: A case report

Primary pineal rhabdomyosarcoma successfully treated by high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation: case report

Primary pineal rhabdomyosarcoma: A rare case

Contact Info

Product

Resources

About