2020
DOI: 10.1016/j.jns.2020.116774
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Primary aldosteronism in young adults with acute stroke: Prevalence and clinical characteristics

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Cited by 8 publications
(16 citation statements)
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“…Although earlier studies found both surgical and medical therapy equally effective, more recent data suggest that surgical treatment leads to better outcomes ( 12 , 13 ). None of our patients underwent subtype testing with adrenal vein sampling and surgery, similar to previous studies ( 29 , 31 ), due to poor functional status or comorbidities in the patients. This emphasizes the importance of early diagnosis of PA, which unfortunately remains suboptimal, with less than 1% of all patients at risk of PA being screened ( 32 ).…”
Section: Discussionmentioning
confidence: 84%
“…Although earlier studies found both surgical and medical therapy equally effective, more recent data suggest that surgical treatment leads to better outcomes ( 12 , 13 ). None of our patients underwent subtype testing with adrenal vein sampling and surgery, similar to previous studies ( 29 , 31 ), due to poor functional status or comorbidities in the patients. This emphasizes the importance of early diagnosis of PA, which unfortunately remains suboptimal, with less than 1% of all patients at risk of PA being screened ( 32 ).…”
Section: Discussionmentioning
confidence: 84%
“…The study found that high ARR, or relative aldosterone excess, was a predictor of stroke in conditions of high sodium intake. In recent years, Tang et al [ 24 ] conducted a survey of the prevalence and clinical characteristics of PA in 116 young adults with acute stroke, and found that the prevalence of PA was at least 12.9% among adults with stroke under 45 years old. Among young patients with a history of hypertension and stroke, the prevalence of PA was 21.2%, which was far higher than the general population and stubborn hypertension according to previous reports.…”
Section: Discussionmentioning
confidence: 99%
“…52 A recent Chinese study identified primary aldosteronism in 12.7% of 116 young adults (<45 years old) who had been admitted for TIA or stroke (hemorrhagic or ischemic). 48 The estimated prevalence was even higher at 21.2% in those with a concurrent history of hypertension. These studies demonstrate that the prevalence of primary aldosteronism is not low among patients with acute stroke, at least in the Asian population, and that testing for primary aldosteronism in suspected cases should be performed (Table 1).…”
Section: Primary Aldosteronism In Secondary Hypertension and Strokementioning
confidence: 95%
“…47 The prevalence of primary aldosteronism increases with advancing stages of hypertension. 48 A cross-sectional study of 1846 patients in the United States evaluated hormonal mechanisms in normotensive individuals and those with hypertension from stage 1 to resistant hypertension. 5 Every BP category from normotension to resistant hypertension displayed a continuum of renin independent aldosterone production.…”
Section: Primary Aldosteronism In Secondary Hypertension and Stroke P...mentioning
confidence: 99%