Primary adrenal schwannoma: a series of 31 cases emphasizing their clinicopathologic features and favorable prognosis

Zhou, Jun; Zhang, Dandan; Li, Wencai; Zhou, Luting; Xu, Hui; Zheng, Saifang; Wang, Chaofu

doi:10.1007/s12020-019-01992-z

Cited by 23 publications

(42 citation statements)

References 37 publications

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“…However, local recurrences have been observed in 33-50% of the cases [18]. Zhou et al reported good survival without any evidence of recurrence or metastasis at follow-up from 7-115 months [2]. In our cases, the patient remained asymptomatic with no evidence of radiological recurrence or distant metastasis at five months after the surgery.…”

Section: Discussionmentioning

confidence: 45%

“…In one series of 33 cases, a median age at the diagnosis was 49 years (14-89 years) with a slight female predominance (F : M = 1.2 :1) [9]. Similarly, Zhou et al also found female predilection (F : M: 1.4 :1) with a median age of 47 years [2]. Differential diagnosis of adrenal schwannomas includes adrenal adenoma, pheochromocytoma, myelolipomas, neuroblastoma, ganglioneuroma, cortical carcinomas, cysts, and metastases [9].…”

Section: Discussionmentioning

confidence: 87%

“…ese tumors are rare and account only for 1-5% of retroperitoneal masses [6]. Schwannoma in the adrenal region is extremely rare, accounting for only 0.7% of the adrenal tumors with about 80 cases have been reported to date [2].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, in case series of 31 patients by Zhou et al the majority (84%) was identified incidentally, and only five patients had symptoms. Of these, three patients were clinically suspicious for the diagnosis of cortisol-producing adenoma; one patient with symptoms prompting the possible diagnosis of aldosterone-producing adenoma; and one patient hospitalized for acute intermittent abdominal pain without evidence of adrenal-relevant hormonal abnormalities [2].…”

Section: Discussionmentioning

confidence: 99%

“…It occurs predominantly in the head and neck regions [1]. Visceral schwannoma in the adrenal region is extremely rare, accounting for only 0.7% of the adrenal tumors [2]. ese tumors are very difficult to diagnose preoperatively, usually present as incidental findings and are often misdiagnosed as adrenal adenoma [3].…”

Section: Introductionmentioning

confidence: 99%

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Schwannoma Misdiagnosed as Adrenal Adenoma: A Case Report and Review of the Literature

Almalki

Alotaibi

Ahmad

et al. 2020

Case Reports in Endocrinology

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Schwannoma is a benign neurogenic tumor originating from the neural sheath of Schwann cells. It is an extremely rare cause of adrenal adenoma which is very difficult to diagnose preoperatively. We report the case of a right adrenal schwannoma discovered incidentally in a 62-year-old woman during evaluation of right flank pain. The biochemical and hormonal evaluations were unremarkable. Radiological examination revealed a 4.8 cm lesion keeping with right adrenal adenoma. Surgical intervention was done due to the large size of the tumor, and laparoscopic right adrenalectomy was performed. The postoperative course was uneventful. Histological examination established the diagnosis of schwannoma, which was further confirmed by immunohistochemical staining. In conclusion, adrenal schwannoma is extremely rare and can be misdiagnosed as nonsecreting adrenal adenoma. Complete surgical excision is the treatment of choice which is associated with favorable outcome and also helps in clarifying its histopathological nature.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Schwannoma Misdiagnosed as Adrenal Adenoma: A Case Report and Review of the Literature

Almalki

Alotaibi

Ahmad

et al. 2020

Case Reports in Endocrinology

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Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis

Tsuchiya,

Ikemura,

Miyawaki

et al. 2024

Brain Tumor Pathol

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Ancient schwannoma (AS) is a subtype of schwannoma characterized by slow progression despite degenerative changes in pathology. Although it is considered a benign tumor, most previous reports have focused on extracranial AS; therefore, the clinical characteristics of intracranial AS is not clear. We included 174 patients who underwent surgery for sporadic intracranial schwannoma, and 13 patients (7.5%) were diagnosed with AS. Cysts were significantly more common in patients with AS than conventional schwannomas (92.3% vs. 44.7%, p < 0.001), as was bleeding (38.5% vs. 6.9%, p = 0.003) and calcification (15.4% vs. 1.3%, p = 0.029). The maximum tumor diameter was also larger in patients with AS (35 mm vs. 29 mm, p = 0.017). The median duration from symptom onset to surgery (7.0 vs. 12.5 months, p = 0.740) did not significantly differ between groups, nor did the probability of postoperative recurrence (p = 0.949). Intracranial AS was strongly associated with cyst formation and exhibited a benign clinical course with a lower rate of recurrence and need for salvage treatment. Extracranial AS is reportedly characterized by a slow progression through a long-term clinical course, whereas intracranial AS did not progress slowly in our study and exhibited different clinical features to those reported for extracranial AS.

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Adrenal schwannoma: why should endocrinologists be aware of this uncommon tumour?

et al. 2022

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Primary adrenal schwannoma: a series of 31 cases emphasizing their clinicopathologic features and favorable prognosis

Cited by 23 publications

References 37 publications

Schwannoma Misdiagnosed as Adrenal Adenoma: A Case Report and Review of the Literature

Schwannoma Misdiagnosed as Adrenal Adenoma: A Case Report and Review of the Literature

Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis

Adrenal schwannoma: why should endocrinologists be aware of this uncommon tumour?

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