Primary Adrenal Sarcomatoid Carcinoma

Shaikh, Aftab; Bakhshi, Girish D.; Khan, Arshad S.; Jamadar, Nilofar M; Nirmala, Aravind Kotresh; Raza, Arif Ahmed

doi:10.4081/cp.2014.604

Cited by 10 publications

(16 citation statements)

References 15 publications

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“…Data collected from the present patient, as well as from the previous 11 reported cases identified in the literature, revealed that the patient age range at the time of presentation with adrenal sarcomatoid carcinoma was 29-79 years, with a mean age of 55.75 years (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The female:male ratio in this small sample size was 1:1.…”

Section: Discussionmentioning

confidence: 51%

“…The first report of primary adrenal sarcomatoid carcinoma was in 1989 by Collina et al (6). At the time of writing the present study, to the best of our knowledge only 11 cases had previously been reported (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The majority of those patients succumbed to disease within a year, due to local recurrence or de novo metastases.…”

Section: Introductionmentioning

confidence: 57%

“…To the best of our knowledge, the present case report describes the 12th reported case of primary adrenal sarcomatoid carcinoma and reviews the previous literature (Table I) (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Data collected from the present patient, as well as from the previous 11 reported cases identified in the literature, revealed that the patient age range at the time of presentation with adrenal sarcomatoid carcinoma was 29-79 years, with a mean age of 55.75 years (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 84%

“…Upon initial presentation with primary adrenal sarcomatoid carcinoma, patients typically complain of abdominal pain or discomfort, lumbago and weight loss (6,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Only 2/12 reported cases were functional tumors (11,12).…”

Section: Discussionmentioning

confidence: 99%

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Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature

Zhu¹,

Zheng²,

Mao³

et al. 2016

Oncology Letters

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Abstract. Adrenal sarcomatoid carcinoma is a rare adrenal carcinoma. To the best of our knowledge, only 11 cases have been reported since 1987. Adrenal sarcomatoid carcinoma presents a diagnostic challenge due to its atypical symptoms and histological patterns. At the time of diagnosis, a large percentage of patients are already at the metastatic stage and succumb within a few months. The present study reports a case of a 59-year-old man presenting with asthenia and weight loss with adrenal sarcomatoid carcinoma metastatic to the lung. A computed tomography (CT) scan and ultrasonography of the patient's abdomen suggested a large homogeneous mass in the right adrenal gland, and a CT scan of his chest suggested lung metastasis. Right adrenalectomy was performed. Histological examination revealed that the tumor was composed of sarcomatous and carcinomatous differentiation elements. Immunohistochemical examination revealed tumor cell positivity for vimentin and cytokeratin. At the 6-month follow-up the patient exhibited no disease progression and refused further proposed treatment. The patient was alive at the time of writing the current report. The present case report additionally reviews the literature, for the purpose of raising awareness of these rare lesions and assisting in achieving accurate diagnoses and effective treatment.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature

Zhu¹,

Zheng²,

Mao³

et al. 2016

Oncology Letters

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“…[17][18][19] It is not difficult to make a definitive diagnosis of sarcomatoid carcinoma if distinctive differentiation into adrenocortical cells is recognized. However, when such differentiation is indistinctive, the diagnosis can be very difficult, and immunostaining should be employed.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Bilateral Sarcomatoid Carcinoma of Adrenal Glands With Adrenal Insufficiency

et al. 2016

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Adrenocortical carcinomas are relatively rare, but they are considered to be highly aggressive malignant tumors. Sarcomatoid carcinomas represent an even more aggressive type. Bilateral malignant adrenal tumors are extraordinary rare, except for those that represent metastatic spread from a primary neoplasm. Here we report a case of a 69-year-old woman who presented symptoms that raised strong suspicions of adrenal insufficiency. Bilateral adrenal masses, identified in the imaging study, were responsible for the clinical manifestation and surgically resected. Surgical specimens of the bilateral adrenal tumors shared histological features compatible with sarcomatoid carcinoma. It was very difficult to confirm that the sarcomatoid carcinomas were derived from the cortex of the adrenal glands, but careful morphological observation and the panel of antibodies used for immunohistochemistry made the diagnosis possible. This is the first report of sarcomatoid carcinomas involving both adrenal glands. It should be emphasized that sarcomatoid carcinoma can arise bilaterally from even functionally impaired adrenal glands.

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Malignant Perivascular Epithelioid Cell Tumor (PEComa) of the Adrenal Gland: Report of a Rare Case Posing Diagnostic Challenge with the Role of Immunohistochemistry in the Diagnosis

et al. 2015

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Histological diagnosis of adrenal tumors is often challenging as diverse groups of tumors, both primaries and metastatic, may be seen in the adrenal gland with overlapping morphological features. Immunohistochemistry (IHC) plays the most important role in their diagnosis. Perivascular epithelioid cell tumor (PEComa), a rarely reported tumor in the adrenal gland, shares many features with another rare tumor sarcomatoid adrenocortical carcinoma (ACC). Extensive immunohistochemical study is required to distinguish this tumor from adrenocortical carcinoma and from other morphologically similar tumors. The unique combination of immunoreactivity for melanocytic markers, such as HMB-45 and Melan A, and myogenic markers, such as smooth muscle actin, is the hallmark of PEComas biological behavior, and prognosis of malignant PEComas is yet to be fully understood. Few cases of malignant PEComa have been reported in the adrenal gland. We report a case of malignant PEComa of the adrenal gland posing diagnostic challenge and compare its morphological and immunohistochemical features with those of sarcomatoid ACC.

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Primary Adrenal Sarcomatoid Carcinoma

Cited by 10 publications

References 15 publications

Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature

Primary adrenal sarcomatoid carcinoma metastatic to the lung: Case report and review of the literature

A Case Report of Bilateral Sarcomatoid Carcinoma of Adrenal Glands With Adrenal Insufficiency

Malignant Perivascular Epithelioid Cell Tumor (PEComa) of the Adrenal Gland: Report of a Rare Case Posing Diagnostic Challenge with the Role of Immunohistochemistry in the Diagnosis

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