Primary Adrenal Lymphoma: Two Case Series From China

Zeng, Jiali; Yan, Fangfang; Chen, Yulong; Zang, Li; Chen, Kang; Lyu, Zhaohui; Dou, Jingtao; Mu, Yiming; Lin, Mingzhu; Yang, Guoqing

doi:10.3389/fendo.2021.778984

Cited by 6 publications

(7 citation statements)

References 41 publications

(50 reference statements)

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“… 22 A retrospective study of 26 patients with primary adrenal lymphoma (which is the largest on this disease we identified in 2022) showed that 81% of subjects had suffered bilateral spreading and 63% of them developed AD. 23 …”

Section: Resultsmentioning

confidence: 99%

Addison’s Disease: Diagnosis and Management Strategies

Cârșote¹,

Nistor²

2023

IJGM

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We aim to overview Addison’s disease (AD) with regard to current diagnosis and management. This is a narrative review of full-length articles published in English between January 2022 and December 2022 (including online ahead of print versions) in PubMed-indexed journals. We included original studies in living humans regardless of the level of statistical significance starting from the key search terms “Addison’s disease” or “primary adrenal insufficiency” in title or abstract. We excluded articles with secondary adrenal insufficiency. Briefly, 199 and 355 papers, respectively were identified; we manually checked each of them, excluded the duplicates, and then selected 129 based on their clinical relevance in order to address our 1-year analysis. We organized the data in different subsections covering all published aspects on the subject of AD. To our knowledge, this is the largest AD retrospective from 2022 on published data. A massive role of genetic diagnosis especially in pediatric cases is highlighted; the importance of both pediatric and adult awareness remains since unusual presentations continue to be described. COVID-19 infection is a strong player amid this third year of pandemic although we still not do have large cohorts in this particular matter as seen, for instance, in thyroid anomalies. In our opinion, the most important topic for research is immune checkpoint inhibitors, which cause a large panel of endocrine side effects, AD being one of them.

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Section: Resultsmentioning

confidence: 99%

Addison’s Disease: Diagnosis and Management Strategies

Cârșote¹,

Nistor²

2023

IJGM

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“…Bilateral adrenal involvement may also lead to adrenal insufficiency in affected individuals. Higher LDH and β2-microglobulin levels in the biochemistry tests imply the diagnosis of adrenal lymphoma; in contrast, the adrenal CD is usually unilateral with no definitive biochemical abnormalities ( 42 , 43 ). An adrenal puncture biopsy can be considered in cases where a definitive diagnosis cannot be made based on imaging and clinical features ( 25 , 44 ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of characteristics of four patients with adrenal unicentric Castleman disease

Wang

et al. 2023

Front. Endocrinol.

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BackgroundCastleman Disease (CD) is a group of diseases with characteristic lymph node histopathology, characterized by marked enlargement of deep or superficial lymph nodes. Adrenal CD is rarely reported, and an accurate preoperative diagnosis of adrenal CD is difficult.MethodWe report four cases of CD in the adrenal gland confirmed by pathology and review the characteristics of this rare disease, highlighting the necessity of diagnostic evaluation and follow-up of the patients.ResultsAll of the patients sought medical advice because of adrenal incidentalomas. No significant abnormalities were presented in the biochemistry or endocrine systems. The imaging suggested a moderate-to-large mass with uneven moderate contrast enhancement of the adrenal region, similar to a pheochromocytoma. All cases were misdiagnosed as pheochromocytomas before operation and finally confirmed by histopathology. Three cases were pathologically diagnosed as hyaline vascular CD, and one case was diagnosed as plasma cell CD. All the patients are alive without recurrence after a median follow-up of 8 years.ConclusionThe adrenal CD should be considered after excluding pheochromocytoma and malignancy in the adrenal region. The long-term prognosis of patients with complete resection of the mass is excellent.

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“…There are less than 300 cases described in the English literature to date. The information on this entity is still limited to case reports and a few case series reported from India [12], China [2,[13][14][15], Europe, and North America [16]. There were only four PAL cases previously reported from Saudi Arabia, and all were NHL [5][6][7][8] and their clinicopathological data are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Experience of Primary Adrenal Lymphoma From Two Tertiary Hospitals

Al-Maghrabi¹

2023

Cureus

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Introduction: Primary adrenal lymphoma (PAL) is a rare tumor. The aim of this study was to demonstrate the histopathological features of PAL at two tertiary hospitals.Materials and methods: All PALs diagnosed between January 2003 and February 2023 were retrieved. Pathology and immunohistochemistry slides were reviewed. Additional immunohistochemical markers were done in selected cases. Follow-up data were obtained.Results: There were 7 cases of PAL. The age range of the patients was 52 to 73 years (median 64 years; mean 63.3 years). There were 4 males (57.1%) and 3 females (42.9%). The clinical manifestations included abdominal pain nausea, vomiting, and loss of weight. There were 4 cases of diffuse large B-cell lymphoma (DLBCL), 2 cases of high-grade B-cell lymphomas, and 1 case of follicular lymphoma. There were 5 cases that were unilateral and 2 cases that were bilateral, and both were high-grade B-cell lymphoma. During follow-up, the 1-year and 2-year overall survival rates were 50% and 33%, respectively. Conclusion: PAL is a disease of the elderly, and DLBCL is the most common pathological type. The prognosis is generally poor. Further reporting of PAL cases might help in understanding this disease and could lead to improvement in its management.

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Primary Adrenal Lymphoma: Two Case Series From China

Cited by 6 publications

References 41 publications

Addison’s Disease: Diagnosis and Management Strategies

Addison’s Disease: Diagnosis and Management Strategies

Analysis of characteristics of four patients with adrenal unicentric Castleman disease

Histopathological Experience of Primary Adrenal Lymphoma From Two Tertiary Hospitals

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