Primary adenosquamous carcinoma of the colon

Abstract

Adenosquamous cell carcinoma (Ad-SCC) of the colon is rare. The pathogenesis of Ad-SCC is unclear, however, several hypotheses have been suggested. The clinical presentation and gross findings of Ad-SCC of the colon are similar to those of adenocarcinoma of the colon, but Ad-SCC has a more aggressive clinical course and a poorer prognosis. We report on two cases of Ad-SCC of the colon with obstruction; a collision-type Ad-SCC that has not only obstruction but also numerous hepatic metastases, and a composite-type Ad-SCC treated with left hemicolectomy followed by an adjuvant chemotherapy.

Adenosquamous Carcinoma Colon – An Aggressive and Rare Neoplasm

“…In our case the lesion was situated in the ascending colon and thus distant from the dentate line. The diagnosis of adenosquamous or squamous cell carcinoma colon also requires the exclusion of squamous cell lined fistulous tract which can initiate an adenosquamous or squamous cell carcinoma colon [5]. Clinical examination of our patient did not show any perianal or colocutaneous fistulous tracts.…”

Value of a new pathological classification of lumbar intervertebral disc herniation based on transforaminal endoscopic observations

“…Novel approaches to the procedure include magnetic resonance assisted surgery (5), irrigation discectomy (15), and an ‘inside out’ technique that identifies pain generators with the patient in an awake and aware state using local anesthesia (16). Although the procedure is generally considered safe, reported complications include post-discectomy pseudocyst formation (17), dural tears (18) and exiting root injury (19). While some studies have indicated that the rate of recurrence is higher with endoscopic procedures, surgical indications and surgeon experience are crucial factors that affect outcomes (7).…”

Adenosquamous Carcinoma of the Cecum: A Rare but Aggressive Form of Colonic Neoplasia

“…Chemotherapy has been used for metastatic disease with some encouraging results [14]. However, more studies are needed to determine the exact role of chemotherapy and whether colorectal ASC has a better response to it compared to colorectal adenocarcinoma [3,7,[15][16][17]. While radiotherapy has an established role in the management of squamous cell carcinoma of the rectum, its part in the management of more proximal colonic cancer with squamous differentiation has not been investigated [3,7,[15][16][17].…”