Primary adenosquamous carcinoma of the stomach: Experience of 11 cases and its clinical analysis

Aoki, Yozo; Tabuse, Katsuyoshi; Wada, Masahiro; Katsumi, Masaharu; Uda, Hirotsugu

doi:10.1007/bf02773859

Cited by 12 publications

(3 citation statements)

References 7 publications

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“…Pure squamous cell carcinoma of the stomach is extremely rare.Clinically, the both patients of the present study showed a rapid clinical course and prognosis was very poor. Studies of large series also reported poor prognosis of adenosquamous carcinoma of the stomach [5, 6]. …”

Section: Discussionmentioning

confidence: 99%

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Adenosquamous Carcinoma of the Stomach: Report of Two Cases

Terada

2009

Gastroen Res

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The author reports two cases of adenosquamous carcinoma of stomach. The first case is an 87-year-old woman who was admitted to our hospital because of nausea and vomiting. Endoscopy revealed a large type 4 tumor in the stomach, and biopsy showed squamous cell carcinoma. Total gastrectomy, cholecystectomy, splenectomy and lymph node dissection were performed. Pathologically, the gastric tumor consisted of a mixture of adenocarcinoma (30% in area) and squamous cell carcinoma (70% in areas). The adenocarcinoma consisted of signet ring cell carcinoma, poorly differentiated carcinoma, and tubular adenocarcinoma. Carcinoma cells invaded into the serosa. The gall bladder, lymph nodes and peritoneum showed metastases of adenocarcinoma. The patient died of five months after operation. The second case is a granulocytecolony stimulating factor producing carcinoma. A 77-year-old woman was admitted to our hospital because of epigastralgia. Marked leukocytosis was present without inflammation. Endoscopic examination revealed a large type 3 tumor, and biopsy showed squamous cell carcinoma. Gastrectomy and lymph node dissection was performed. Pathologically the gastric tumor was composed of a mixture of adenocarcinoma (10%) and squamous cell carcinoma (90%). The carcinoma invaded into subserosa. Lymphovascular permeation is present. The adenocarcinoma element consisted of signet ring cell carcinoma. Tumor cells were immunohistochemically positive for granulocyte-colony stimulating factor. The lymph nodes showed metastases of signet ring cell carcinoma. The patient showed systemic metastasis, and died eight months after the operation

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Section: Discussionmentioning

confidence: 99%

“…This disease has been sporadically reported as case reports [1-4], and comprehensive studies using large series are a few [5-7]. The author reports two cases of adenosquamous carcinoma of the stomach.…”

Section: Introductionmentioning

confidence: 99%

Adenosquamous Carcinoma of the Stomach: Report of Two Cases

Terada

2009

Gastroen Res

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“…3B ). These tumors have a poor prognosis owing to their deep penetration and high propensity for lymphovascular invasion, which often results in an advanced stage at diagnosis and a higher likelihood of metastasis [ 18 19 ].…”

Section: Adenosquamous Carcinomamentioning

confidence: 99%

Unusual or Uncommon Histology of Gastric Cancer

Shin,

Park

2024

J Gastric Cancer

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This review comprehensively examines the diverse spectrum of gastric cancers, focusing on unusual or uncommon histology that presents significant diagnostic and therapeutic challenges. While the predominant form, tubular adenocarcinoma, is well-characterized, this review focuses on lesser-known variants, including papillary adenocarcinoma, micropapillary carcinoma, adenosquamous carcinoma, squamous cell carcinoma (SCC), hepatoid adenocarcinoma, gastric choriocarcinoma, gastric carcinoma with lymphoid stroma, carcinosarcoma, gastroblastoma, parietal cell carcinoma, oncocytic adenocarcinoma, Paneth cell carcinoma, gastric adenocarcinoma of the fundic gland type, undifferentiated carcinoma, and extremely well-differentiated adenocarcinoma. Although these diseases have different nomenclatures characterized by distinct histopathological features, these phenotypes often overlap, making it difficult to draw clear boundaries. Furthermore, the number of cases was limited, and the unique histopathological nature and potential pathogenic mechanisms were not well defined. This review highlights the importance of understanding these rare variants for accurate diagnosis, effective treatment planning, and improving patient outcomes. This review emphasizes the need for ongoing research and case studies to enhance our knowledge of these uncommon forms of gastric cancer, which will ultimately contribute to more effective treatments and better prognostic assessments. This review aimed to broaden the pathological narrative by acknowledging and addressing the intricacies of all cancer types, regardless of their rarity, to advance patient care and improve prognosis.

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Squamous metaplasia in colorectal polyps

Almagro

Pintar

Zellmer

1984

Cancer

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Two cases of rectal polyps that showed foci of squamous metaplasia are reported. in one, the squamous metaplasia was observed in an area of intramucosal adenocarcinoma. This finding tends to reinforce the contention previously made by some authors that squamous metaplasia in colorectal polyps may represent the precursor of primary colorectal squamous cell carcinoma or colorectal adenocarcinoma with squamous components (adenoacanthoma or adenosquamous carcinoma).

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Primary adenosquamous carcinoma of the stomach: Experience of 11 cases and its clinical analysis

Cited by 12 publications

References 7 publications

Adenosquamous Carcinoma of the Stomach: Report of Two Cases

Adenosquamous Carcinoma of the Stomach: Report of Two Cases

Unusual or Uncommon Histology of Gastric Cancer

Squamous metaplasia in colorectal polyps

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