Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico

Abstract

Background:Mexico's National Institute of Respiratory Diseases (NIRD) is a third-level national reference center. Primary adenoid cystic carcinoma (PACC) is an uncommon neoplastic disorder; hence improvements in the description of this disease are needed.Materials and Methods:This is a retrospective clinical study based on all consecutive patients with pathological diagnoses of PACC seen at the NIRD between January 1, 2000 and December 31, 2009.Results:We identified 9 cases of PACC (67% female) out of a total of 2,634 patients with lung cancer seen during the period analyzed. The mean age of those 9 patients was 41 years (IQR 36-57), and the frequency of PACC at our center was 0.3%. It is important to note that 67% of those patients had a history of smoking and that 6 of the 9 had the antecedent of previous exposure to biomass fuel smoke. Baseline arterial blood gas analyses revealed a median of 61 mmHg for pO2 and 28.5 mmHg for pCO2. Median FVC was 78%, while FEV1 was 77% with an FEV1 /FVC ratio of 78. Death occurred in 56% of cases, and the median survival time was 17 months (IQR 6-26) after the initial diagnosis.Conclusions:The frequency of tracheobronchial PACC among patients with lung cancer was similar to that previously reported (0.3%). According to our results, lung function has no specific phenotype in this disease; however, some abnormalities could be related to potential risk factors such as tobacco use and exposure to biomass fuel smoke.

Tracheobronchial tumors

“…Therefore, most patients present with locally advanced disease. But, despite this fact, prognoses are good unless metastases are detected (45). The CT scan is a useful imaging procedure for ACC.…”

Metachronous Adenoid Cystic Carcinoma in the Peripheral Lung and at Base of the Tongue

“…Over the last 10 years, approximately 60 cases of primary lung ACC have been reported in the English literatures [2,3,4]. ACC of the head and neck is typically characterized by a slow-growing malignancy which results in approximately 4% to 20% loco-regional recurrence and 20% to 50% distant metastasis.…”

“…Primary lung adenoid cystic carcinoma (ACC) is very rare, accounts for approximately 0.1% to 0.2% of all lung cancers, and only accounts for about 10% of all lung ACCs [ 1 ]. Over the last 10 years, approximately 60 cases of primary lung ACC have been reported in the English literatures [ 2 , 3 , 4 ]. ACC of the head and neck is typically characterized by a slow-growing malignancy which results in approximately 4% to 20% loco-regional recurrence and 20% to 50% distant metastasis.…”