Primary adenocarcinoma of the rectovaginal septum without associated endometriosis

Langmár, Zoltán; Németh, Miklós; Mátrai, Tamás; Iványi, Kálmán; Harsányi, László; Dank, Magdolna; Székely, Eszter; Kazy, Zoltán

doi:10.1556/cemed.4.2010.28442

Cited by 2 publications

(5 citation statements)

References 8 publications

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“…Several cases of PMRS have been described in the literature (Table 1), excluding GIST 1–8,13–17 . As presented in Table 1, 13 of the 15 patients studied had adenocarcinomas.…”

Section: Discussionmentioning

confidence: 96%

“…Several cases of PMRS have been described in the literature (Table 1), excluding GIST. [1][2][3][4][5][6][7][8][13][14][15][16][17] As presented in Table 1, 13 of the 15 patients studied had adenocarcinomas. The trends of CK7(+), PAX8(+), and CK20(À) indicate that the tumors were of gynecological origin, for example, from endometriosis or the mesonephric duct; however, not all immunohistochemical results were available from these studies.…”

Section: Discussionmentioning

confidence: 99%

“…A few cases of PMRS have been described in the literature, and adjuvant chemotherapy or radiation therapy following radical surgery, aimed at R0 resection has been performed. [1][2][3][4][5][6][7][8] However, it is difficult to achieve complete resection with sufficient surgical margins while preserving urinary or anal function in these procedures, especially when the tumor is large and located in the low rectovaginal septum.…”

Section: Introductionmentioning

confidence: 99%

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Transanal total mesorectal excision for primary rectovaginal carcinosarcoma: A case report and literature review

Onishi¹,

Amano

Miyake

et al. 2022

J of Obstet and Gynaecol

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We report a case of rectovaginal septum carcinosarcoma successfully treated with surgical excision via transanal total mesorectal excision following platinum-based neoadjuvant chemotherapy. A 48-year-old woman presented with a 3-week defecation pain preceding the visit. Pelvic imaging showed an 8-cm sized lesion in the lower rectovaginal septum. Transvaginal biopsy and immunohistochemical analysis were performed. After three courses of carboplatin-paclitaxel-bevacizumab therapy, the mass reduced by half. Subsequently, laparoscopic excision with transanal total mesorectal excision, and radical hysterectomy were performed. The anus was preserved, and dysuria improved within a month. The final histopathological diagnosis was carcinosarcoma of the rectovaginal septum from an uncertain origin, presumably endometriotic or mesonephric. Twelve months following surgery, solitary liver metastasis was confirmed; however, there was no evidence of local recurrence. Total mesorectal excision following platinum-based neoadjuvant chemotherapy may be an ideal treatment for gynecological malignancies in the rectovaginal septum, especially for large tumors localized deep into the pelvis.

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“…Several cases of PMRS have been described in the literature (Table 1), excluding GIST 1–8,13–17 . As presented in Table 1, 13 of the 15 patients studied had adenocarcinomas.…”

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Transanal total mesorectal excision for primary rectovaginal carcinosarcoma: A case report and literature review

Onishi¹,

Amano

Miyake

et al. 2022

J of Obstet and Gynaecol

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“…PARS is a rare malignant tumor that arises from the rectovaginal septum, the majority of cases of which have been reported to occur from endometriosis (1,2). To the best of our knowledge, only six cases of PARS without associated endometriosis have been reported in the literature (3)(4)(5)(6)(7)(8). Therefore, the case described here is considered to be the seventh reported case of PARS without associated endometriosis, and the first reported case in which the tumor was completely removed by total laparoscopic PPE.…”

Section: Discussionmentioning

confidence: 99%

“…Primary adenocarcinoma of the rectovaginal septum (PARS) is a rare neoplasm that arises predominantly from endometriosis (1,2), and PARS without associated endometriosis is even rarer. To the best of our knowledge, there are only six previous cases of PARS without associated endometriosis described in the literature (3)(4)(5)(6)(7)(8). The present report represents a case of laparoscopic posterior pelvic exenteration (PPE) for PARS without associated endometriosis, which may have arisen from metaplasia of the embryological Müllerian-duct remnants.…”

Section: Introductionmentioning

confidence: 87%

Laparoscopic posterior pelvic exenteration for primary adenocarcinoma of the rectovaginal septum without associated endometriosis: A case report

et al. 2018

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The present report describes a case of laparoscopic posterior pelvic exenteration of a primary adenocarcinoma of the rectovaginal septum (PARS) without associated endometriosis. A 49-year-old woman was admitted to hospital for rectal bleeding. Imaging studies showed a 7-cm solid tumor located in the rectovaginal septum, presenting with invasion to the posterior aspect of the uterine cervix and the anterior rectal wall. The patient received laparoscopic posterior exenteration and rectosigmoid anastomosis followed by chemotherapy. There were no intra-or post-operative complications. Histopathological examination of the neoplastic tissue revealed moderate to severe cytological atypia with bizarre multinucleated cells and prominent mitotic figures. Histopathologically, R0 resection was achieved. No endometriotic lesions were confirmed in the primary tumor or other removed tissues. Immunohistochemistry showed positive staining for cytokeratin (CK)7, cancer antigen 125, vimentin, estrogen receptor and p53, but negative staining for CK20, progesterone receptor, p40 and thyroid transcription factor 1. Based on these findings and on the location of the tumor, the neoplasm was diagnosed as PARS without associated endometriosis, which may have arisen from metaplasia of the embryological Müllerian-duct remnants.

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Primary adenocarcinoma of the rectovaginal septum without associated endometriosis

Cited by 2 publications

References 8 publications

Transanal total mesorectal excision for primary rectovaginal carcinosarcoma: A case report and literature review

Transanal total mesorectal excision for primary rectovaginal carcinosarcoma: A case report and literature review

Laparoscopic posterior pelvic exenteration for primary adenocarcinoma of the rectovaginal septum without associated endometriosis: A case report

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