Primary Adenocarcinoma of the Eyelid with Signet Ring Cell and Histiocytoid Features

Nazareth, Michael R.; Bogner, Paul N.; Mansour, Natalie; Raghu, Preethi; Mansour, Tamer N.; Zeitouni, Nathalie C.

doi:10.1111/j.1524-4725.2012.02544.x

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…However, our study indicated that lymph node metastasis is seen more frequently in axillary SRCHC cases than in eyelid SRCHC cases [8/11 (73%) versus 1/4 (25%)], even though eyelid SRCHC cases had larger tumours in our study. A literature review also revealed the predominance of axillary SRCHC [10/14 (71%) versus 8/43 (19%)] 2,3,5–7,14–51,54,55 . Distant metastasis was seen in approximately half of both axillary and eyelid SRCHC cases [5/11 (45%) versus 2/4 (50%)].…”

Section: Discussionmentioning

confidence: 98%

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Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

et al. 2021

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Aims The aim of this study was to determine the clinicopathological and genetic characteristics of axillary signet‐ring cell/histiocytoid carcinoma (SRCHC) and the relationship between axillary SRCHC, eyelid SRCHC, and conventional apocrine carcinoma (AC). Methods and results Eleven cases of axillary SRCHC, four cases of eyelid SRCHC, eight cases of axillary AC and five cases of invasive lobular carcinoma (ILC) were retrieved. Additionally, 14 axillary and 43 eyelid SRCHC cases from the literature were reviewed. Male predominance was prominent for axillary SRCHC (24:1) and eyelid SRCHC (42:5). Axillary SRCHC formed a circumscribed plaque or nodule, unlike eyelid SRCHC. Lymph node metastasis was predominantly seen in axillary SRCHC cases (72%, 18/25), but not in eyelid SRCHC cases (19%, 9/47). Axillary SRCHC and eyelid SRCHC were histopathologically similar and showed rare tubular formations. Immunoexpression of cytokeratin 7, cytokeratin 19, mucin 1, mucin 5AC, BerEP4 and androgen receptor was seen in all tested cases of the four diseases. Oestrogen and progesterone receptors were negative in both types of SRCHC and AC, but were strongly positive in ILCs. Complete loss of E‐cadherin expression was seen in approximately one‐quarter of both types of SRCHC and in all ILCs. PIK3CA mutations were detected in all three sequenced cases (two axillary SRCHCs and one eyelid SRCHC). Conclusion The histopathological, immunohistochemical and genetic findings suggest that both types of SRCHC are phenotypic variants of AC, although there are differences in sex, macroscopic findings and the frequency of lymph node metastasis among the three. In contrast, ILC differs from the other three tumour types.

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Section: Discussionmentioning

confidence: 98%

“…These were similar to those for conventional AC 52,53 . There were no SRCHC cases located in areas other than the axilla and eyelid 2,3,5–7,14–51,54,55 . Thus, metastasis should be considered for cases arising at other sites.…”

Section: Discussionmentioning

confidence: 99%

Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

et al. 2021

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“…Immunophenotypically, the cells show reactivity for a subset of cytokeratins (CAM 5.2, CK7, AE1/3 and MNF116) as well as CEA, GCDFP‐15, lysozyme, CD15, epithelial membrane antigen and, in some cases, S100 protein . Other markers like CK20, p63, HER2, ER and PR are positive in some reports but negative in others . Negative ER and PR staining may be helpful in differentiating this neoplasm from breast carcinoma .…”

Section: Discussionmentioning

confidence: 99%

Primary signet‐ring cell carcinoma of the axilla

et al. 2012

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Primary cutaneous histiocytoid or signet-ring cell carcinoma represents an extremely rare adnexal neoplasm that most frequently presents on the eyelid but more rarely may present in the axilla. As this tumor can resemble metastatic carcinoma with signet-ring cells, especially lobular carcinoma of the breast, it can often present a diagnostic challenge. We present a case of cutaneous signet-ring cell carcinoma presenting in the axilla and outline the challenges of diagnosing this rare malignancy.

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“…Primary signet ring cell/histiocytoid carcinoma, thought to derive from cutaneous apocrine or eccrine glands, has been reported on numerous occasions in the eyelid [9][10][11][12][13][14][15][16][17][18][19][20][21]. In addition to the significant morphologic overlap with lobular breast carcinoma and the current case [5], these tumors share immunohistochemical features as well [21].…”

Section: Microscopic Differential Diagnosis: Primary Tumors Originatimentioning

confidence: 76%

“…Infrequently signet ring cells may be focally observed, in but not universally constitutive of, non-sclerosing glandular tumors of the head and neck, including those of the salivary glands [7,8]. However, sclerosing signet ring arising from the cutaneous apocrine or eccrine glands of the eyelids and other cutaneous sites have been repeatedly reported [9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Sclerosing Signet Ring Cell Carcinoma of the Lacrimal Gland: A Potentially New Primary Entity

Reshef

Selig

et al. 2020

Ocul Oncol Pathol

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Primary Adenocarcinoma of the Eyelid with Signet Ring Cell and Histiocytoid Features

Cited by 6 publications

References 5 publications

Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

Primary signet‐ring cell carcinoma of the axilla

Sclerosing Signet Ring Cell Carcinoma of the Lacrimal Gland: A Potentially New Primary Entity

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