Primary abdominal lymphoma

Freeman, Hugh James; Weinstein, Wilfred M.; Shnitka, T. K.; Piercey, J.; Wensel, Ronald H.

doi:10.1016/0002-9343(77)90204-2

Cited by 109 publications

(9 citation statements)

References 31 publications

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“…Typical intestinal symptoms are absent or minimal and some have termed this presentation as "silent". Some initially present with the skin disorder, dermatitis herpetiformis,21,22 autoimmune thyroid disease,23 insulin-dependent diabetes,24 a small intestinal carcinoma25 or lymphoma 26. Occult celiac disease has also been associated with other intestinal disorders including: collagenous colitis,27 lymphocytic colitis,28 lymphocytic sclerosing cholangitis,29 collagenous and lymphocytic gastritis 30…”

Section: Occult and Latent Celiac Diseasementioning

confidence: 99%

“…Often, these are lymphomas that complicate already well established celiac disease. But, in some, lymphoma as well as other malignancies, such as small bowel adenocarcinoma, actually precede recognition of celiac disease,25,26 providing further evidence for an intimate clinical linkage.…”

Section: Intestinal Malignancies and Risk In Celiac Diseasementioning

confidence: 99%

“…Concomitant nodal involvement may be present 54. In some, a definite pathological diagnosis of lymphoma may be particularly difficult in the presence of either small intestinal (including duodenal) erosions or ulcers 26. Crohn's ulceration or a label of "ulcerative jejunoileitis" may be recorded 26.…”

Section: Lymphoma Diagnosis In Celiac Diseasementioning

confidence: 99%

“…In some, a definite pathological diagnosis of lymphoma may be particularly difficult in the presence of either small intestinal (including duodenal) erosions or ulcers 26. Crohn's ulceration or a label of "ulcerative jejunoileitis" may be recorded 26. Some of these ulcerating lesions, however, later prove to contain frankly neoplastic lymphoma cells that may be difficult to appreciate in severely inflamed small intestine.…”

Section: Lymphoma Diagnosis In Celiac Diseasementioning

confidence: 99%

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Adult Celiac Disease and Its Malignant Complications

Freeman¹

2009

Gut Liver

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Adult celiac disease is a chronic intestinal disorder that has been estimated to affect up to 1-2% of the population in some nations. Awareness of the disease has increased, but still it remains markedly underdiagnosed. Celiac disease is a pathologically defined condition with several characteristic clinical scenarios that should lead the clinician to suspect its presence. Critical to diagnosis is a documented responsiveness to a gluten-free diet. After diagnosis and treatment, symptoms and biopsy-proven changes may recur and appear refractory to a gluten-free diet. Recurrent symptoms are most often due to poor diet compliance, a ubiquitous and unrecognized gluten source, an initially incorrect diagnosis, or an associated disease or complication of celiac disease. Some patients with persistent symptoms and biopsy-proven changes may not have celiac disease at all, instead suffering from a sprue-like intestinal disease, so-called unclassified sprue, which is a specific entity that does not appear to respond to a gluten-free diet. Some of these patients eventually prove to have an underlying malignant cause, particularly lymphoma. The risk of developing lymphoma and other malignancies is increased in celiac disease, especially if initially diagnosed in the elderly, or late in the clinical course of the disease. However, recent studies suggest that the risk of gastric and colon cancer is low. This has led to the hypothesis that untreated celiac disease may be protective, possibly due to impaired absorption and more rapid excretion of fat or fat-soluble agents, including hydrocarbons and other putative cocarcinogens, which are implicated in the pathogenesis of colorectal cancer.

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Section: Occult and Latent Celiac Diseasementioning

confidence: 99%

Section: Intestinal Malignancies and Risk In Celiac Diseasementioning

confidence: 99%

Section: Lymphoma Diagnosis In Celiac Diseasementioning

confidence: 99%

Section: Lymphoma Diagnosis In Celiac Diseasementioning

confidence: 99%

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Adult Celiac Disease and Its Malignant Complications

Freeman¹

2009

Gut Liver

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“…In Central Europe and North America, lympho mas in a gastric location are more frequent, whereas the intestinal ones are rather uncommon and there is no prevalence in the site [41,51]. In contrast, lympho mas of the small intestine, especially in the higher tract, are present in several regions of the Middle East [9,22]; they occur predominantly in young adults and seem to be associated with specific socioeconomic patterns. The average age of appearance of pathology is 51 years, ranging from 7 to 82 years.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Primary Gastrointestinal Involvement in Non-Hodgkin’s Lymphomas

Cajozzo¹,

Perricone²,

Abbadessa³

et al. 1987

Acta Haematol

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This paper reviews primary gastrointestinal non-Hodgkin’s lymphoma (GI-NHL). Every aspect of the topic is discussed though special attention is paid to histopathology and instrumental diagnosis as essential factors to stage the lymphoma and to determine an adequate therapy. Data from the most important works on the subject together with the results of our recent study of 40 primary GI-NHL are reported. Diverse findings by various authors are intentionally compared in a manner to present the work to the reader in the most critical way while trying to give an objective explanation of the different results on the basis of our own experience

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Lymphomas of the gastrointestinal tract.A study of 117 cases presenting with gastrointestinal disease

Lewin

Ranchod

Dorfman

1978

Cancer

582

175

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A study was made of 117 patients who presented with gastrointestinal lymphoma. The occurrence was 48 in the stomach, 37 in the small intestine, 13 in the ileocecal region, two in the appendix and 11 in the large intestine. In six cases, multiple sites in the gastrointestinal tract were involved, but in five cases this appeared to be secondary to massive mesenteric or retroperitoneal lymph node disease. Using Rappaport's classification, diffuse histiocytic lymphoma was the most frequent histologic type and constituted 60% of the cases. Nodular lymphomas comprised 10% of the total, nodular poorly differentiated lymphocytic lymphoma forming the majority of this group. Ten of the lymphomas were undifferentiated, 5 of Burkitt's type and 5 non-Burkitt's type. Five were Mediterranean-type lymphomas associated with plasma cell infiltration of the adjacent mucosa, and only two cases of primary Hodgkin's disease were encountered. Two lymphomas could not be classified. Eight percent of the cases showed plasmacytoid changes and were classified as a distinct subgroup of the parent lymphoma rather than as examples of extramedullary plasmacytoma. Gastrointestinally lymphomas occurred most frequently during the fourth to seventh decades. However, nine lymphomas occurred in children younger than 16 years of age. In comparison to adults, the childhood lymphomas showed a number of notable differences with respect to sex distribution, site of involvement and histologic type. Information concerning the extent of the disease at the time of diagnosis was available in 75 cases. Of these, 49% of the lymphomas were confined to the affected viscus and 33% had associated regional lymph node involvement; the remaining 18% had mode widespread disease. In 44 patients information on the spread of disease was available and in 48% there was extra abdominal spread. Prognosis appeared to correlate best with the stage of the disease rather than the histologic type.

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Primary abdominal lymphoma

Cited by 109 publications

References 31 publications

Adult Celiac Disease and Its Malignant Complications

Adult Celiac Disease and Its Malignant Complications

Primary Gastrointestinal Involvement in Non-Hodgkin’s Lymphomas

Lymphomas of the gastrointestinal tract.A study of 117 cases presenting with gastrointestinal disease

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