Primärer primitiver neuroektodermaler Tumor der Harnblase

Mentzel, Thomas; Flaschka, J; Mentzel, HJ; Eschholz, G.; Katenkamp, D.

doi:10.1007/s002920050269

Cited by 17 publications

(4 citation statements)

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“…Other neural markers showed different results in pPNET diagnostics. Whereas S100 protein was positive in our case, this marker showed different results in other pPNET patients with positive [3,4,6] and negative staining [8,9]. Cytokeratins, epithelial membrane antigen, desmin (CD33), smooth muscle actin, chromogranin and leucocyte common antigen (CD3 und CD20) were not significant markers in this case, in accordance with the results of Desai and Banerjee et al [8,9].…”

Section: Discussionsupporting

confidence: 84%

“…In the present case, the immunohistochemistry profile supported the diagnosis of pPNET. As in most reported cases of pPNET, our patient showed positivity for neuron-specific enolase and MIC2 gene [3,5,6,8]. Other neural markers showed different results in pPNET diagnostics.…”

Section: Discussionsupporting

confidence: 51%

“…pPNET belong to the Ewing's sarcoma family of tumors and share the same immunohistochemical profiles and molecular genotypes [3]. Tumor cell staining of these masses was shown to be positive for MIC2 gene product (CD99) and neural markers such as neuron-specific enolase (NSE), vimentin, S100 protein or synaptophysin [3]-[6]. Primitive neuroectodermal tumors of the urinary tract are very rare, more often occurring in renal masses than as bladder tumors [3].…”

Section: Introductionmentioning

confidence: 99%

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Peripheral primitive neuroectodermal tumor of the urinary bladder in an Arab woman with history of squamous cell carcinoma: a case report

et al. 2009

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IntroductionPeripheral primitive neuroectodermal tumors of the urinary bladder are rare and tend to occur in an older age group than do their counterparts in bones and soft tissue.Case presentationWe report a case of peripheral primitive neuroectodermal tumor of the urinary bladder in a 67-year-old woman of Arab origin. She had undergone transurethral resection followed by chemotherapy because of pulmonary metastasized muscle-invasive squamous cell carcinoma of the bladder in 2005. One year later, she first presented with a history of repeated hematuria in our institution. Performing cystoscopy any tumor could be detected. Control cystoscopy two months later showed a tumor mass of 3 cm in diameter at another location than described for the first tumor. After perforating by transurethral resection partial bladder resection had to be done. Tissue specimen after pathological analysis revealed a peripheral primitive neuroectodermal tumor with tumor cells reactive to cluster of differentiation 99, neuron-specific enolase and S100 protein and stained negative for other markers such as cytokeratins, epithelial membrane antigen, desmin, smooth muscle actin, chromogranin and leucocyte common antigen. Staging computerized tomography was especially free from any hint on organ metastasis, but the patient died due to a cardiac problem only a few months later.ConclusionsTo the best of our knowledge, we report the eighth case of bladder peripheral primitive neuroectodermal tumors in literature and the first concerning an Arab patient. It is also the first presentation of a peripheral primitive neuroectodermal tumor patient with a history of squamous cell carcinoma of the bladder. As in other cases, expression of single-chain-type 1 glycoprotein and neural markers was positive and the disease was at an advanced stage at the time of diagnosis.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

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Peripheral primitive neuroectodermal tumor of the urinary bladder in an Arab woman with history of squamous cell carcinoma: a case report

et al. 2009

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“…The desmoplastic small round cell tumor is characterized by sharply circumscribed nests or clusters of small, undifferentiated cells surrounded by a desmoplastic stroma, and show positivity for cytokeratin and desmin, but negativity for CD99. Therefore, the phenotypes observed in our case, i.e., positive expression of CD99, vimentin, NSE, and synaptophysin, and negative expression of cytokeratins, CD3, desmin, and LCA, are highly suggestive of a pulmonary PNET [3,9-11]. …”

Section: Discussionmentioning

confidence: 83%

Primary pulmonary primitive neuroectodermal tumor metastasis to the pancreas: a rare case with seven-year follow-up

Shi

Guo

2013

Diagn Pathol

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There are only nine primitive neuroectodermal tumor (PNET) cases that have arisen in lung parenchyma without pleural or chest wall involvement in the literature. Here, we present a long–term survival case of pulmonary PNET. A pulmonary mass was detected in a 19-year-old man on a chest radiograph and computed tomography image. At the three-year follow-up, the mass had enlarged in diameter by two-fold. The lesion was resected via lower left lobectomy. Histologically, the tumor was composed of uniform cells with round nuclei and scanty cytoplasm arranged in lobules with rosettes and pseudorosettes formation. Immunohistochemically, the tumor was positive for CD99, vimentin, neuron specific enolase and chromogranin A, and negative for cytokeratins, CD3, desmin, and leukocyte common antigen. Pancreatic metastasis occurred sixteen months after the first surgery, which was managed by pancreatectomy. The patient has survived seven years after the mass was initially detected, and four years after the first lobectomy.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1500847644913244

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Fine‐needle aspiration cytology of primitive neuroectodermal tumor of the urinary bladder: A case report

Rao

Sinha

Babu

et al. 2010

Diagnostic Cytopathology

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Primitive neuroectodermal tumors (PNETs) are malignant small round cell tumors, which exhibit a variable degree of neural differentiation. These tumors are usually found in the extraosseous soft tissue and rarely in bones. Occasional cases of PNETs of the urinary bladder have been reported on histopathology. However, to the best of our knowledge, none have been diagnosed on fine-needle aspiration cytology (FNAC). A patient presented to the out-patient department with complaints of a slowly progressive lump in the lower abdomen, which was diagnosed as PNET on FNAC. The smears showed a dispersed population and sheets of malignant small round cells with focal rosette formation and perivascular arrangement of tumor cells. Periodic acid-Schiff staining showed strong cytoplasmic positivity. Immunocytochemistry of the cytology smears also showed strong membrane positivity for CD99 (MIC-2), which was also confirmed on histopathological examination. PNET of the urinary bladder is a distinct entity, which can be diagnosed on FNAC and confirmed by immunohistochemistry. A diagnosis of PNET should be considered as a differential diagnosis in urinary bladder masses, especially in adolescents and young adults.

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Primärer primitiver neuroektodermaler Tumor der Harnblase

Cited by 17 publications

References 0 publications

Peripheral primitive neuroectodermal tumor of the urinary bladder in an Arab woman with history of squamous cell carcinoma: a case report

Peripheral primitive neuroectodermal tumor of the urinary bladder in an Arab woman with history of squamous cell carcinoma: a case report

Primary pulmonary primitive neuroectodermal tumor metastasis to the pancreas: a rare case with seven-year follow-up

Fine‐needle aspiration cytology of primitive neuroectodermal tumor of the urinary bladder: A case report

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