PRILE 2021 guidelines for reporting laboratory studies in Endodontology: explanation and elaboration

Abstract

Guidance to authors is needed to prevent their waste of talent, time and resources in writing manuscripts that will never be published in the highest‐quality journals. Laboratory studies are probably the most common type of endodontic research projects because they make up the majority of manuscripts submitted for publication. Unfortunately, most of these manuscripts fail the peer‐review process, primarily due to critical flaws in the reporting of the methods and results. Here, in order to guide authors, the Preferred Reporting Items for study Designs in Endodontology (PRIDE) team developed new reporting guidelines for laboratory‐based studies: the Preferred Reporting Items for Laboratory studies in Endodontology (PRILE) 2021 guidelines. The PRILE 2021 guidelines were developed exclusively for the area of Endodontology by integrating and adapting the modified CONSORT checklist of items for reporting in vitro studies of dental materials and the Clinical and Laboratory Images in Publications (CLIP) principles. The process of developing the PRILE 2021 guidelines followed the recommendations of the Guidance for Developers of Health Research Reporting Guidelines. The aim of the current document is to provide authors with an explanation for each of the items in the PRILE 2021 checklist and flowchart with examples from the literature, and to provide advice from peer‐reviewers and editors about how to solve each problem in manuscripts prior to their peer‐review. The Preferred Reporting Items for study Designs in Endodontology (PRIDE) website (http://pride-endodonticguidelines.org/prile/) provides a link to the PRILE 2021 explanation and elaboration document as well as to the checklist and flowchart.

Influence of Static Navigation Technique on the Accuracy of Autotransplanted Teeth in Surgically Created Sockets

“…The sample size was selected according to a previous study with a power effect of 88.4 (it is considered acceptable from 80) [28]. The manuscript of this laboratory study has been written according to 2021 Preferred Reporting Items for Laboratory studies in Endodontology (PRILE) guidelines (Figure 1) [29,30]. In addition, the study was conducted in accordance with the principles defined in the German Ethics Committee's statement for the use of organic tissues in medical research (Zentrale Ethikkommission, 2003) and was authorized by the Ethical Committee of the Faculty of Health Sciences, University Alfonso X el Sabio (Madrid, Spain), in October 2020 (Process No.…”

A Comparative Analysis of the Piezoelectric Ultrasonic Appliance and Trephine Bur for Apical Location: An In Vitro Study

“…In order to obtain statistically significant differences with a power effect of 80.00% to detect differences between the null hypothesis H 0 : μ 1 = μ 2 via a bilateral Student’s t -test of two independent samples, taking into account a significance level of 5.00%, 138 osteotomy site preparations were included in the study. The resulting manuscript for this study was written in accordance with the 2021 Preferred Reporting Items for Laboratory Studies in Endodontology (PRILE) guidelines [ 18 , 19 ]. In addition, the in vitro study was conducted as per the principles laid out in the German Ethics Committee’s statement on the use of organic tissues in medical research (Zentrale Ethikkommission, 2003).…”

A critical analysis of research methods and experimental models to study tooth discolouration from endodontic materials

“…In 2021, the Preferred Reporting Items for study Designs in Endodontology (PRIDE) team developed specific reporting guidelines for endodontic laboratory studies, with the goal of ensuring that laboratory studies in endodontology were described comprehensively and that details of methodology were transparent. The Preferred Reporting Items for Laboratory studies in Endodontology (PRILE) guidelines were published in September 2021 (Nagendrababu et al, 2021). These guidelines consist of 40 items in 11 sections arranged in a checklist, along with a flowchart.…”