Priapism secondary to penile metastasis: A report of two cases and a review of the literature

Chan, Peter; Bégin, Louis R.; Arnold, Donald; Jacobson, Stephen; Corcos, Jacques; Brock, Gerald

doi:10.1002/(sici)1096-9098(199805)68:1<51::aid-jso11>3.0.co;2-u

Cited by 76 publications

(61 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, only 4 (2.1%) of 189 controls reported ever having had such an experience, thus resulting in a statistically significant multivariate OR of 9.2. We deliberately excluded those priapic episodes that occurred <5 years before the time of diagnosis to avoid inclusion of cancerrelated priapism (27)(28)(29). All seven penile SCC patients with a positive history reported that the priapic episode antedated the cancer diagnosis by 10 or more years, thus reducing the possible distorting influence of priapism secondary to malignancy.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Squamous Cell Carcinoma of the Penis—Population-Based Case-Control Study in Denmark

Madsen

Brule²,

Jensen

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

111

103

View full text Add to dashboard Cite

Few etiologic studies of squamous cell carcinoma (SCC) of the penis have been carried out in populations where childhood circumcision is rare. A total of 71 patients with invasive (n = 53) or in situ (n = 18) penile SCC, 86 prostate cancer controls, and 103 population controls were interviewed in a population-based casecontrol study in Denmark. For 37 penile SCC patients, tissue samples were PCR examined for human papillomavirus (HPV) DNA. Overall, 65% of PCR-examined penile SCCs were high-risk HPV-positive, most of which (22 of 24; 92%) were due to HPV16. Penile SCC risk was positively associated with measures of early and high sexual activity, including lifetime number of female sex partners, number of female sex partners before age 20, age at first intercourse, penile-oral sex, a history of anogenital warts, and never having used condoms. Histories of phimosis and priapism at least 5 years before diagnosis were also significant risk factors, whereas alcohol abstinence was associated with reduced risk. Our study confirms sexually transmitted HPV16 infection and phimosis as major risk factors for penile SCC and suggests that penileoral sex may be an important means of viral transmission. The association with priapism was unexpected and needs replication. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2683 -91)

show abstract

Section: Discussionmentioning

confidence: 99%

Risk Factors for Squamous Cell Carcinoma of the Penis—Population-Based Case-Control Study in Denmark

Madsen

Brule²,

Jensen

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

111

103

View full text Add to dashboard Cite

show abstract

“…Penile metastases present as a nonulcerative nodule in 51 % of the cases. Other manifestations of penile metastases include priapism in 27 %, urinary symptoms (urethral hemorrhage, hematuria, incontinence, and irritative and obstructive symptoms) in 27 %, pain in 17 %, retention in 13 %, and skin lesions in 11 % [19]. In the present case, the patient had a nonulcerative penile nodule without any overt symptoms.…”

Section: Discussionmentioning

confidence: 54%

Efficacy and safety of gemcitabine monotherapy in an elderly patient with penile metastasis from bladder carcinoma: a case report

et al. 2013

View full text Add to dashboard Cite

We describe the case of an 85-year-old Japanese male with invasive urothelial carcinoma of the bladder treated with radiotherapy and the significant effects of gemcitabine monotherapy on subsequent metastases to the lungs, L5 vertebral body, and penis. The lung and L5 vertebral body metastases were diagnosed 3 months after radiotherapy and were treated with one course of gemcitabine and cisplatin chemotherapy. As the patient was unable to continue the chemotherapy, the chemotherapy was switched to two further courses of gemcitabine monotherapy, and he showed a significant response to the metastasis. The patient's condition was good until he noticed a penile nodule that appeared 2.5 years after the radiotherapy. The penile tumor was pathologically confirmed as metastatic urothelial carcinoma. The patient received one additional course of gemcitabine monotherapy. At a 1-year follow-up examination, he was still alive and had responded completely to the treatment for the penile metastasis. Metastatic involvement of the penis is an exceptionally rare condition. It is important to consider the balance between the tolerability and efficacy of chemotherapy and that gemcitabine monotherapy might be acceptable in an elderly patient with metastatic urothelial carcinoma who is still in good physical condition. The findings in this case suggest that gemcitabine monotherapy may be one possible candidate for the treatment of metastatic urothelial carcinoma, even in patients aged 80 years or older.

show abstract

“…This suggests that these types of malignancies should be carefully investigated especially in aged priapism patients. Chan et al 27 reviewed 52 cases of penile metastasis, and 14 (27%) presented with priapism, including 2 lung malignancy cases and 12 urological malignancy ones. Therefore, non-urological malignancy also can lead to priapism.…”

Section: Discussionmentioning

confidence: 99%

Incidence and clinical features of priapism in Japan: 46 cases from the Japanese diagnosis procedure combination database 2006–2008

et al. 2011

View full text Add to dashboard Cite

We investigated the incidence and clinical features of priapism in Japan, using a national administrative claims database, the Diagnosis Procedure Combination database. Priapism patients were identified using the International Classification of Diseases and Related Health Problems, 10th Revision code, N483 (priapism). Verified patient characteristics included age, comorbidities and management of priapism. Among 6.93 million inpatients, 46 patients with priapism were identified. Four had two admissions each for repeated events. The median age was 41.5 years (range, 11-89 years). A total of 21 patients had comorbidities; 3 had haematological malignancies, 4 had haemodialysis, 1 had a renal transplant, 2 had neurological problems, 4 had non-haematological malignancies, 3 had trauma and 6 had psychoses (2 cases had two comorbidities). All patients with non-haematological malignancies were over the age of 70 years, indicating that close attention is required to search for associated malignancies in elderly patients. The medical treatments included 6 vascular embolizations, 11 Winter method surgeries and 18 other operations. The incidence was estimated to be 0.13 (95% confidence interval, 0.097-0.17) per 100 000 person-years. This incidence was lower than that reported in other parts of the world.

show abstract

Priapism secondary to penile metastasis: A report of two cases and a review of the literature

Cited by 76 publications

References 41 publications

Risk Factors for Squamous Cell Carcinoma of the Penis—Population-Based Case-Control Study in Denmark

Risk Factors for Squamous Cell Carcinoma of the Penis—Population-Based Case-Control Study in Denmark

Efficacy and safety of gemcitabine monotherapy in an elderly patient with penile metastasis from bladder carcinoma: a case report

Incidence and clinical features of priapism in Japan: 46 cases from the Japanese diagnosis procedure combination database 2006–2008

Contact Info

Product

Resources

About