1987
DOI: 10.1016/s0022-5347(17)44355-2
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Priapism Induced by Chlorpromazine and Trazodone: Mechanism of Action

Abstract: To investigate the mechanism of drug-induced priapism, we gave the antipsychotic agent chlorpromazine and the antidepressant trazodone to 14 dogs by intravenous and intracorporeal injection. Bilateral intracorporeal pressure, blood flow within the internal pudendal artery, and systemic blood pressure were monitored. Venous outflow restriction was evaluated by continuous saline infusion of the corpus cavernosum with the infrarenal aorta clamped. When delivered by intracorporeal injection, both drugs induced ere… Show more

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Cited by 73 publications
(33 citation statements)
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“…40 Intracavernosal trazadone was found to be associated with priapism in a canine model. 38 Saenz de Tejada et al reported on the pathophysiology of prolonged erections associated with trazodone use. 41 Trazodone signi®cantly improved nocturnal penile tumescence.…”
Section: Alpha Adrenergic Receptor Blockade In Erectile Dysfunctionmentioning
confidence: 99%
See 1 more Smart Citation
“…40 Intracavernosal trazadone was found to be associated with priapism in a canine model. 38 Saenz de Tejada et al reported on the pathophysiology of prolonged erections associated with trazodone use. 41 Trazodone signi®cantly improved nocturnal penile tumescence.…”
Section: Alpha Adrenergic Receptor Blockade In Erectile Dysfunctionmentioning
confidence: 99%
“…41 These observations suggest that trazodone hydrochloride acts peripherally via a mechanism mimicking alpha blocking properties. 38,40,41 It should be noted that metabolites of trazadone can activate hydroxytryptamine receptors (HT1c) in the spinal cord, and these metabolites are believed to contribute to the erectogenic effect of this drug (reviewed in ref. 27).…”
Section: Alpha Adrenergic Receptor Blockade In Erectile Dysfunctionmentioning
confidence: 99%
“…37 Drug-induced priapism, which as suggested implies a medication-related phenomenon, represents another variant that has resulted from use of alpha-adrenergic antihypertensives, psychotropic agents, antidepressant medications, cocaine, and pharmacotherapeutic agents for erectile dysfunction. [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] The mechanism of action is contended to relate to peripheral and central signaling pathways stimulated by the offending drug that produce corporal smooth muscle relaxation.…”
Section: Abnormal Penile Blood Flowmentioning
confidence: 99%
“…9 ± 14 Further studies have yielded information on the mechanism by which trazodone affects penile activity. 7,15,16 Trazodone seems to possess an ability to enhance penile erectile activity due to its alphaadrenoceptor blocking activity, which locally interferes with the sympathetic control of penile detumescence. 7 Apart from this effect on erectile function, trazodone has been suggested as a treatment option for loss of libido in some case reports.…”
Section: Introductionmentioning
confidence: 99%