Priapism in the Oncology Setting

Abstract

N.L. is a 20-year-old Caucasian man with no significant medical history. He presented to the hospital with a two-day history of feeling ill with intermittent nausea, vomiting, blurred vision, and headache. He also noted slurred speech and left-upper-quadrant fullness for almost a month.

Priapism as the first manifestation in chronic myeloid leukemia: A case report and focused review of literature

“…For example, Gupta et al described a case of a 12‐year‐old boy with intermittent 2‐week‐long priapism which later became sustained in the last 48 h and resolved after the CML management along with administration of subcutaneous terbutaline 6 . Megan et al described a case of a 20‐year‐old patient, where priapism was resolved only after localized penile radiotherapy following unsuccessful treatment with aspiration, phenylephrine injections, and CML management 24 . However, Ergenc et al described a case of an 18‐year‐old patient with priapism which was resolved only by initiating acute management of CML 13 .…”

“…6 Megan et al described a case of a 20-year-old patient, where priapism was resolved only after localized penile radiotherapy following unsuccessful treatment with aspiration, phenylephrine injections, and CML management. 24 However, Ergenc et al described a case of an 18-year-old patient with priapism which was resolved only by initiating acute management of CML. 13 Additionally, only one reported case treated with interferon α-2a achieved adequate response with no recurrent priapism.…”

The value of leukapheresis for treatment of priapism as presenting feature of chronic myeloid leukemia—Case report and review of literature

“…A total of seven patients received shunt surgery, five after unsuccessful detumescence after penile aspiration and injection [30,32,33,47,50]. Two patients were treated with a third modality and received penile radiation therapy [40,49]. Oncological management consisted of hyperhydration and cytoreductive therapy for all patients.…”

“…Some case reports reported start of treatment with chemotherapy or TKI when diagnosis of CML was established. Five cases used leukapheresis, the amount of sessions performed is not reported [3,32,40,46,49]. In 85% of the patients, detumescence was reached after treatment, 15.4% (n = 4) reported ED.…”

“…A total of 11 reports used leukapheresis in treatment of the hyperviscosity causing priapism, consisting of 12 patients (Table 5). Eight case reports used leukapheresis in a combined treatment modality with urological interventions [25,30,32,40]. Three reports used only an oncological approach [12,13,18].…”