Priapism Caused by Infection and an Inflammatory Process in the Pelvic Region

Ouden, D. van den; Boks, Simone S.; Sinnige, H.A.W.

doi:10.1159/000068759

Cited by 6 publications

(4 citation statements)

References 15 publications

(21 reference statements)

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“…Inflammatory markers such as circulating C-reactive protein (CRP) and interleukin-6 (IL-6) are predictive of coronary artery disease in the general population [7] and are correlated with poor outcomes in the CKD population [6, 8, 9]. Studies suggest that in maintenance hemodialysis (MHD) patients a paradoxical association exists between low serum cholesterol and increased all-cause and CV death [4,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Sevelamer and Calcium-Based Phosphate Binders on Lipid and Inflammatory Markers in Hemodialysis Patients

Shantouf¹,

Budoff²,

Ahmadi³

et al. 2007

Am J Nephrol

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Introduction: Cardiovascular disease accounts for almost half of all deaths in individuals with chronic kidney disease stage 5 despite advances in both dialysis treatment and cardiology. A combination of lipid-lowering and anti-inflammatory effects along with avoidance of hypercalcemia should be taken into account when choosing phosphorus binders for maintenance hemodialysis (MHD) patients. Methods: We examined the association of sevelamer versus calcium-based phosphorus binders with lipid profile, inflammatory markers including C-reactive protein (CRP), and mineral metabolism in MHD patients who participated in the Nutritional and Inflammatory Evaluation of Dialysis Patients (NIED) study from October 2001 to July 2005. Results: Of the 787 MHD patients in the NIED study, 697 were on either sevelamer, a calcium-based binder, or both and eligible for this study. We compared the groups based on taking sevelamer monotherapy (n = 283) or calcium binder monotherapy (n = 266) for serum phosphate control. There were no differences between the groups on dialysis vintage. There were significant differences in age, serum calcium and phosphorus levels, as well as intact parathyroid hormone levels. Using a logistic regression models, the sevelamer group had a higher odds of serum CRP <10 mg/l [odds ratio (OR): 1.06, 95% CI: 1.02–1.11] and LDL cholesterol <70 mg/dl (OR: 1.33, 95% CI: 1.19–1.47) when compared to the calcium binder group independent of age, vintage, body mass index, statin use or other variables. Conclusion: The improvements in multiple surrogate markers of inflammation and lipids in the NIED study make sevelamer a promising therapy for treatment in MHD patients with high risk of cardiovascular disease and mortality.

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Section: Introductionmentioning

confidence: 99%

Effects of Sevelamer and Calcium-Based Phosphate Binders on Lipid and Inflammatory Markers in Hemodialysis Patients

Shantouf¹,

Budoff²,

Ahmadi³

et al. 2007

Am J Nephrol

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“…It has been reported in systemic infections such as mumps, Rocky Mountain spotted fever, tularemia, undulant fever, Mycoplasma pneumoniae , Coxsackie B and Echovirus 14 ( 8 , 10 , 21 , 22 , 23 ). Appendicitis, Crohn disease, ulcerative colitis and localized urogenital infections, such as chronic prostatitis and urethritis can cause pelvic inflammation that can lead to irritation the nervi erigentes or pelvic plexus causing a neurogenic LFP ( 9 , 24 , 25 ). There are six reported cases of LFP associated with appendicitis appearing in the literature to date and all of them are males ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

Non-hormonal Clitoromegaly due to Clitoral Priapism Caused by Appendicitis/Appendectomy

Tosun¹,

Akgül²,

Almus³

et al. 2023

Jcrpe

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Clitoromegaly usually develops due to hyperandrogenism. There are a few cases of clitoromegaly described without clinical and biochemical hyperandrogenism. Clitoromegaly due to clitoral priapism and clitoral priapism after appendectomy have not been reported previously. A 7-year-old girl was referred for enlargement of the clitoris. She reported having a mild, pulsating clitoral pain starting three days after an appendectomy operation. Subsequently, painful swelling and an increase in the size of the clitoris was observed. Her growth and physical examination were otherwise normal. Causes of the clitoromegaly due to androgen excess were excluded after a comprehensive work-up. Color Doppler ultrasound revealed a high peak systolic velocity and resistance in the cavernosal artery, consistent with clitoral priapism. The clitoromegaly and associated symptoms improved significantly with oral pseudoephedrine and intracavernosal aspiration. This unique case illustrates that clitoral priapism is a rare, non-hormonal cause of clitoromegaly and may occur after appendectomy. Pseudoephedrine treatment is helpful in alleviating the symptoms.

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“…Pelvic inflammation can be caused by appendicitis [5,6,9], Crohn disease [10] and ulcerative colitis [11], and localized urogenital infections such as chronic prostatitis and urethritis and can lead to irritation the nervi erigendi or pelvic plexus causing a neurogenic LFP [12]. This suggests that the etiology of the association between pelvic inflammation and LFP is the abnormal and sustained To our knowledge, this is the fourth reported case of LFP associated with appendicitis appearing in the literature ( Table 1).…”

Section: Discussionmentioning

confidence: 99%