Priapism as the Presenting Manifestation of Multiple Myeloma

Sahu, Kamal Kant; Mishra, Kundan; Dhibar, Deba Prasad; Ram, T. Kalyan; Kumar, G Ganesh; Jain, Sanjay; Naseem, Shano; Malhotra, Pankaj

doi:10.1007/s12288-016-0722-7

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…Presence of oro‐nasal bleed mandates thorough retinal evaluation since hemorrhages may occur without visual symptomatology. Furthermore, clinical signs including hypertension, congestive heart failure, 5 priapism 6 and decreased hearing merit consideration.…”

Section: Discussionmentioning

confidence: 99%

Hyperviscosity syndrome complicating immunoglobulin G myeloma—Cognisance of early plasmapheresis is crucial

Sood

Mishra

Bahl

et al. 2022

Seminars in Dialysis

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Hyperviscosity syndrome (HVS) is an infrequent but life-threatening complication of multiple myeloma (MM) and classically presents with the triad of mucosal bleed, neurological, and visual disturbances. HVS is typically associated with immunoglobulin M (IgM) MM and very rarely may complicate immunoglobulin G (IgG) MM. Even suspicion of HVS necessitates therapy based on clinical severity rather than the calculated degree of viscosity. While plasmapheresis promptly decreases serum viscosity by 30% to 50%, early initiation of anti-myeloma therapy is crucial to prevent rebound phenomena. In this context, we report a case of IgG MM, which despite being complicated by HVS had gratifying outcome attributable to early clinical suspicion and consequent prompt therapeutic intervention.

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Section: Discussionmentioning

confidence: 99%

Hyperviscosity syndrome complicating immunoglobulin G myeloma—Cognisance of early plasmapheresis is crucial

Sood

Mishra

Bahl

et al. 2022

Seminars in Dialysis

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“…In contrast to Reis et al , targeted exon sequencing done by Kardos et al (12 cases) revealed genetic alterations (eg, microsatellite instability- MSH2 and MSH6) similar to colorectal cancer 14. Reis et al found 31% and 16% expression of RAS/RAF/PI3K and PD-L1, respectively, in their study sample thereby prompting the potential role of anti‐PD‐1/PD‐L1 and anti‐epidermal growth factor receptor (EGFR) targeted anti-tyrosine kinase inhibitor (TKI) therapy.Awareness of rare urological conditions especially oncological is extemely important for timely diagnosis and treatment 8 15 16…”

Section: Discussionmentioning

confidence: 99%

Mystery of neck lump: an uncommon presentation of urachal cancer

et al. 2019

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We present the case of a 55-year-old male patient who presented with palpable cervical lymphadenopathy. Excisional biopsy showed metastatic adenocarcinoma of unknown origin. Imaging showed a bladder mass following which he underwent transurethral resection of bladder tumour. Histopathological evaluation of mass confirmed a poorly differentiated adenocarcinoma with signet-ring cell features. Immunohistochemistry was suggestive of metastatic urachal cancer. He agreed for enrollment in a clinical trial, however soon after 1st cycle, he developed immune pneumonitis requiring high dose steroids. On follow-up, MRI brain was done for evaluation of headache which showed metastatic intracranial disease. He completed radiotherapy following which he was started on FOLFOX chemo regimen (folinic acid, 5-fluorouracil and oxaliplatin).

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“…Calciphylaxis should be differentiated from the diseases that could have similar clinical presentations such as warfarin skin necrosis, cryoglobulinemia, vasculitis, cellulitis, nephrogenic fibrosing dermopathy, and cholesterol l embolization. Differential’s penile lesions[ 14 ] include balanitis, Bechet’s syndrome, sexually transmitted diseases, malignancy, Peyronie’s disease, and syringoma calcification, which are all unlikely in the patient presented here based on history of physical examination, laboratory results, and imaging.…”

Section: How To Diagnosementioning

confidence: 99%

Penile calciphylaxis - A rare, yet medically treatable disease

Sampathkumar,

Siddharth,

Veerappan

et al. 2023

Indian J Nephrol

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Calciphylaxis or calcific uremic arteriolopathy (CUA) is an infrequent complication in patients with renal failure. Its manifestations range from ischemia to gangrene especially in areas of adiposity. Penile calciphylaxis is very rarely seen. Treatment can be medical or surgical. Sodium thiosulphate has shown to be an efficient treatment. Here were present a case of 74-year-old male who presented with penile calciphylaxis and was treated successfully with oral sodium thiosulphate.

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Priapism as the Presenting Manifestation of Multiple Myeloma

Cited by 9 publications

References 7 publications

Hyperviscosity syndrome complicating immunoglobulin G myeloma—Cognisance of early plasmapheresis is crucial

Hyperviscosity syndrome complicating immunoglobulin G myeloma—Cognisance of early plasmapheresis is crucial

Mystery of neck lump: an uncommon presentation of urachal cancer

Penile calciphylaxis - A rare, yet medically treatable disease

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