Prey populations with different predation histories show differences in behavioral and transcriptional effects under acute predation threat

Rivi, Veronica; Batabyal, Anuradha; Benatti, Cristina; Tascedda, Fabio; Blom, Johanna Maria Catharina; Lukowiak, Ken

doi:10.1016/j.nlm.2023.107775

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…Using our model system, the pond snail Lymnaea stagnalis , we have been able to begin to uncover aspects of the causal neuronal mechanisms underlying learning and its subsequent consolidation into long-term memory (LTM) [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

LPS-Induced Garcia Effect and Its Pharmacological Regulation Mediated by Acetylsalicylic Acid: Behavioral and Transcriptional Evidence

Rivi

Batabyal

Lukowiak

et al. 2023

Biology

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Lymnaea stagnalis learns and remembers to avoid certain foods when their ingestion is followed by sickness. This rapid, taste-specific, and long-lasting aversion—known as the Garcia effect—can be formed by exposing snails to a novel taste and 1 h later injecting them with lipopolysaccharide (LPS). However, the exposure of snails to acetylsalicylic acid (ASA) for 1 h before the LPS injection, prevents both the LPS-induced sickness state and the Garcia effect. Here, we investigated novel aspects of this unique form of conditioned taste aversion and its pharmacological regulation. We first explored the transcriptional effects in the snails’ central nervous system induced by the injection with LPS (25 mg), the exposure to ASA (900 nM), as well as their combined presentation in untrained snails. Then, we investigated the behavioral and molecular mechanisms underlying the LPS-induced Garcia effect and its pharmacological regulation by ASA. LPS injection, both alone and during the Garcia effect procedure, upregulated the expression levels of immune- and stress-related targets. This upregulation was prevented by pre-exposure to ASA. While LPS alone did not affect the expression levels of neuroplasticity genes, its combination with the conditioning procedure resulted in their significant upregulation and memory formation for the Garcia effect.

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Section: Introductionmentioning

confidence: 99%

LPS-Induced Garcia Effect and Its Pharmacological Regulation Mediated by Acetylsalicylic Acid: Behavioral and Transcriptional Evidence

Rivi

Batabyal

Lukowiak

et al. 2023

Biology

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Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis

Rivi,

Caruso,

Caraci

et al. 2024

J of Neuroscience Research

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Carnosine is a naturally occurring endogenous dipeptide with well‐recognized anti‐inflammatory, antioxidant, and neuroprotective effects at the central nervous system level. To date, very few studies have been focused on the ability of carnosine to rescue and/or enhance memory. Here, we used a well‐known invertebrate model system, the pond snail Lymnaea stagnalis, and a well‐studied associative learning procedure, operant conditioning of aerial respiration, to investigate the ability of carnosine to enhance long‐term memory (LTM) formation and reverse memory obstruction caused by an immune challenge (i.e., lipopolysaccharide [LPS] injection). Exposing snails to 1 mM carnosine for 1 h before training in addition to enhancing memory formation resulted in a significant upregulation of the expression levels of key neuroplasticity genes (i.e., glutamate ionotropic receptor N‐methyl‐d‐aspartate [NMDA]‐type subunit 1—LymGRIN1, and the transcription factor cAMP‐response element‐binding protein 1—LymCREB1) in snails' central ring ganglia. Moreover, pre‐exposure to 1 mM carnosine before an LPS injection reversed the memory deficit brought about by inflammation, by preventing the upregulation of key targets for immune and stress response (i.e., Toll‐like receptor 4—LymTLR4, molluscan defense molecule—LymMDM, heat shock protein 70—LymHSP70). Our data are thus consistent with the hypothesis that carnosine can have positive benefits on cognitive ability and be able to reverse memory aversive states induced by neuroinflammation.

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Snails go on a fast when acetylsalicylic acid comes along with heat stress: A possible effect of HSPs and serotonergic system on the feeding response

Batabyal,

Rivi,

Benatti

et al. 2024

Comparative Biochemistry and Physiology Part C: Toxicology &

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Prey populations with different predation histories show differences in behavioral and transcriptional effects under acute predation threat

Cited by 5 publications

References 42 publications

LPS-Induced Garcia Effect and Its Pharmacological Regulation Mediated by Acetylsalicylic Acid: Behavioral and Transcriptional Evidence

LPS-Induced Garcia Effect and Its Pharmacological Regulation Mediated by Acetylsalicylic Acid: Behavioral and Transcriptional Evidence

Behavioral and transcriptional effects of carnosine in the central ring ganglia of the pond snail Lymnaea stagnalis

Snails go on a fast when acetylsalicylic acid comes along with heat stress: A possible effect of HSPs and serotonergic system on the feeding response

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