Preweanling sensorial and motor development in laboratory mice: Quantitative trait loci mapping

Roy, Isabelle Le; Pérez-Díaz, Fernando; Cherfouh, Améziane; Roubertoux, Pierre L.

doi:10.1002/(sici)1098-2302(199903)34:2<139::aid-dev7>3.0.co;2-h

Cited by 32 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our chromosome 4 habituation locus overlaps with Start2 (Le Roy et al . ). Previously identified QTL on chromosome 6 for anxiety and depression behaviors do not overlap with our open‐field immobility QTL ( Rear1 , Kelly et al .…”

Section: Discussionmentioning

confidence: 97%

High‐precision genetic mapping of behavioral traits in the diversity outbred mouse population

Logan

Robledo

Recla

et al. 2013

Genes Brain and Behavior

111

138

View full text Add to dashboard Cite

Historically our ability to identify genetic variants underlying complex behavioral traits in mice has been limited by low mapping resolution of conventional mouse crosses. The newly developed Diversity Outbred (DO) population promises to deliver improved resolution that will circumvent costly fine mapping studies. The DO is derived from the same founder strains as the Collaborative Cross (CC), including three wild derived strains. Thus the DO provides more allelic diversity and greater potential for new discovery compared to crosses involving standard mouse strains. We have characterized 283 male and female DO mice using open-field, light-dark box, tail-suspension, and visual-cliff avoidance tests to generate 38 behavioral measures. We identified several quantitative trait loci (QTL) for these traits with support intervals ranging from 1 to 3 Mb in size. These intervals contain relatively few genes (ranging from 5 to 96). For a majority of QTL, using the founder allelic effects together with whole genome sequence data, we could further narrow the positional candidates. Several QTL replicate previously published loci. Novel loci were also identified for anxiety- and activity-related traits. Half of the QTLs are associated with wild-derived alleles, confirming the value to behavioral genetics of added genetic diversity in the DO. In the presence of wild-alleles we sometimes observe behaviors that are qualitatively different from the expected response. Our results demonstrate that high-precision mapping of behavioral traits can be achieved with moderate numbers of DO animals, representing a significant advance in our ability to leverage the mouse as a tool for behavioral genetics.

show abstract

Section: Discussionmentioning

confidence: 97%

High‐precision genetic mapping of behavioral traits in the diversity outbred mouse population

Logan

Robledo

Recla

et al. 2013

Genes Brain and Behavior

111

138

View full text Add to dashboard Cite

show abstract

“…Consistent with the minimum number of effective factors estimated to modulate ASR (7 and 4 on A/J and C57BL/6J backgrounds, respectively), we identified seven provisional QTLs increasing ASR on the A/J background and eight on the C57BL/6J. LeRoy et al (1999) have reported on three provisional QTLs modulating acoustic startle in chromosomal mapping studies with preweanling C57Bl/6By and NZB/B1NJ inbred mice and their F 1 s and F 2 s. These QTLs do not overlap with QTLs identified in the present study, possibly due to age differences in experimental animals. In studies with human populations, monozygotic twins have been reported to exhibit a greater degree of similarity in ASR than do dizygotic twins (Carlson et al 1997), supporting the idea that ASR is under partial genetic control in humans.…”

Section: Discussionmentioning

confidence: 99%

Provisional Mapping of Quantitative Trait Loci Modulating the Acoustic Startle Response and Prepulse Inhibition of Acoustic Startle

Joober¹,

Zarate

Rouleau³

et al. 2002

Neuropsychopharmacology

View full text Add to dashboard Cite

Prepulse inhibition (PPI) of the acoustic startle response (ASR) is a form of sensorimotor gating, defined as an inhibition of the startle response when a low intensityThere is strong evidence that several genes with additive or interactive effects, together with environmental factors, contribute to confer susceptibility to schizophrenia (Carlson and Willott 1996). Given this complexity, one approach to uncover genetic susceptibility factors in schizophrenia has been to search for genes regulating specific endophenotypes within schizophrenia. Prepulse inhibition (PPI) of the startle response is a candidate phenotype which may be relevant to such a strategy.

show abstract

“…In C57BL/6J mice, the natural instinct abilities such as cliff aversion and geotaxis reflexes normally appear within 10 days postnatally (Le Roy, Perez‐Diaz, Cherfouh, & Roubertoux, ), and have attended after that as valued tools for assessing neurological function status (Ten, Bradley‐Moore, Gingrich, Stark, & Pinsky, ). In addition to the righting reflex and NSS evaluation, we also assessed cliff aversion and geotaxis reflexes to evaluate short‐term (1 day) neurofunctional outcome following TBI.…”

Section: Methodsmentioning

confidence: 99%

Modified device for fluid percussion injury in rodents

Ouyang

Fan

et al. 2018

J of Neuroscience Research

View full text Add to dashboard Cite

Fluid percussion (FP) injury model is a popular animal model of traumatic brain injury (TBI), but still there are some issues need to be addressed. To increase the validity and reliability of this technique, we adapted the FP device using electromagnetic protractor, stainless-steel cylinder, changing pressure transducer position, and foam pads to adjust the parameters of FP pulse. Besides, the adjusted FP device is more automatic. The FP pulse is promptly measured and displayed in a graphic user interface software. The modified device resulted in reliable FP pulse. The accuracy of the pendulum leveling was improved with using the electromagnetic protractor with slots. We then collected behavioral, cognition, electrophysiological, and immunohistochemical data to verify the percussion effects in TBI mice. Lateral fluid percussion injury (FPI) or sham treatment was administered at the right frontal motorsensory region of male C57BL/6J mice. TBI mice showed evident motor, cognitive, and functional impairments, characterized by evaluation of neurological, righting, geotaxis and cliff aversion reflexes, limb asymmetrical use, rotarod running, and Morris water maze testing. The neurobehavioral damages were scaled with histopathological findings. Further, the overall firing rates and theta powers in hippocampal CA1 were significantly reduced in TBI mice compared to sham mice at Days 2 and 3 after electrode implanting. The adapted device induced effects on behavior and biology in mice that agree with existing models. These findings confirmed the validity of adjustments, and the modified device may boost the interest in TBI studies.

show abstract

Preweanling sensorial and motor development in laboratory mice: Quantitative trait loci mapping

Cited by 32 publications

References 32 publications

High‐precision genetic mapping of behavioral traits in the diversity outbred mouse population

High‐precision genetic mapping of behavioral traits in the diversity outbred mouse population

Provisional Mapping of Quantitative Trait Loci Modulating the Acoustic Startle Response and Prepulse Inhibition of Acoustic Startle

Modified device for fluid percussion injury in rodents

Contact Info

Product

Resources

About