Preweaning food intake influences the adiposity of young adult baboons.

Lewis, David N.; Bertrand, Helen A.; McMahan, C. Alex; McGill, Henry C.; Carey, K. Dee; Ej, Masoro

doi:10.1172/jci112678

Cited by 140 publications

(91 citation statements)

References 32 publications

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“…Animal studies demonstrate that overfeeding during infancy leads to higher adiposity during adolescence (56). In humans, a greater decline in weight for length z score between 3 and 12 months was found for breastfed compared with formula-fed infants (57,58).…”

Section: Breastfeeding and Early Neonatal Growthmentioning

confidence: 99%

Breastfeeding After Gestational Diabetes Pregnancy

Gunderson

2007

Diabetes Care

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Section: Breastfeeding and Early Neonatal Growthmentioning

confidence: 99%

Breastfeeding After Gestational Diabetes Pregnancy

Gunderson

2007

Diabetes Care

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“…Thus, in rats, offspring exposed to early postnatal overnutrition as a consequence of suckling by mothers on a high-fat diet, as a result of artificial feeding with a high-carbohydrate diet or as a result of rearing in small litters are at increased risk of obesity and cardiometabolic disease (Plagemann et al 1992, Srinivasan et al 2008. Importantly, such effects are also noted in other species including non-human primates, for example overfeeding in the pre-weaning period increases adiposity in female baboons in young adulthood (Lewis et al 1986). …”

Section: Timing Of Exposurementioning

confidence: 99%

Impact of maternal obesity on offspring obesity and cardiometabolic disease risk

Drake¹,

Reynolds²

2010

Reproduction

442

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The prevalence of obesity among pregnant women is increasing. In addition to the short-term complications of obesity during pregnancy in both mother and child, it is now recognised that maternal obesity has long-term adverse outcomes for the health of her offspring in later life. Evidence from both animal and human studies indicates that maternal obesity increases the risk for the offspring in developing obesity and altering body composition in child-and adulthood and, additionally, it also has an impact on the offspring's cardiometabolic health with dysregulation of metabolism including glucose/insulin homoeostasis, and development of hypertension and vascular dysfunction. Potential mechanisms include effects on the development and function of adipose tissue, pancreas, muscle, liver, the vasculature and the brain. Further studies are required to elucidate the mechanisms underpinning the programming of disease risk in the offspring as a consequence of maternal obesity. The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations.

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“…Samples of omental adipose tissue were analyzed for triglyceride content, cell size and cell number per gram of tissue as described by Lewis et al 24 The remaining sample was frozen immediately and stored at À801C.…”

Section: Animalsmentioning

confidence: 99%