Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training

Lourenço, Ítalo; Neto, Walter Krause; Amorim, Laura Dos Santos Portella; Ortiz, Vagner Moraes Munhoz; Geraldo, Vitor Lopes; Ferreira, Gabriel Henrique da Silva; Lima, Jackson Torres de; Massoni, Amanda Alves Ribeiro; Oliveira, Beatriz Massensini; Anaruma, Carlos Alberto; Ciena, Adriano Polican; Gama, Eliane Florêncio; Caperuto, Érico Chagas

doi:10.1016/j.tice.2022.101741

Cited by 1 publication

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main T esters used in TRT (or as anabolic drugs) are, nowadays, largely centered on T undecanoate [ 429 , 430 , 431 ], but also include propionate [ 432 , 433 , 434 , 435 ], isobutyrate [ 436 ], oleate—a natural AcT—[ 437 ], enanthate [ 438 , 439 , 440 ], undecenoate [ 441 ], cypionate [ 442 ], butyryl-cyclocarbonate [ 443 ], phenyl-propionate and decanoate [ 444 ]. Gradual-release T ester blends are also used to obtain extended time-uniform T release patterns, as is the case of Sustanon 250 [ 445 , 446 ] (a mixture of T propionate, isocaproate, phenyl-propionate and decanoate).…”

Section: Current Pharmacological Utilization Of Androgensmentioning

confidence: 99%

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

Alemany

2022

IJMS

View full text Add to dashboard Cite

Androgens are an important and diverse group of steroid hormone molecular species. They play varied functional roles, such as the control of metabolic energy fate and partition, the maintenance of skeletal and body protein and integrity and the development of brain capabilities and behavioral setup (including those factors defining maleness). In addition, androgens are the precursors of estrogens, with which they share an extensive control of the reproductive mechanisms (in both sexes). In this review, the types of androgens, their functions and signaling are tabulated and described, including some less-known functions. The close interrelationship between corticosteroids and androgens is also analyzed, centered in the adrenal cortex, together with the main feedback control systems of the hypothalamic–hypophysis–gonads axis, and its modulation by the metabolic environment, sex, age and health. Testosterone (T) is singled out because of its high synthesis rate and turnover, but also because age-related hypogonadism is a key signal for the biologically planned early obsolescence of men, and the delayed onset of a faster rate of functional losses in women after menopause. The close collaboration of T with estradiol (E2) active in the maintenance of body metabolic systems is also presented Their parallel insufficiency has been directly related to the ravages of senescence and the metabolic syndrome constellation of disorders. The clinical use of T to correct hypoandrogenism helps maintain the functionality of core metabolism, limiting excess fat deposition, sarcopenia and cognoscitive frailty (part of these effects are due to the E2 generated from T). The effectiveness of using lipophilic T esters for T replacement treatments is analyzed in depth, and the main problems derived from their application are discussed.

show abstract

Section: Current Pharmacological Utilization Of Androgensmentioning

confidence: 99%

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

Alemany

2022

IJMS

View full text Add to dashboard Cite

show abstract

Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training

Cited by 1 publication

References 38 publications

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

Contact Info

Product

Resources

About