Previous challenges and current progress–the use of total artificial hearts in patients with end-stage heart failure

Goerlich, Corbin E.; Frazier, O.H.; Cohn, William E.

doi:10.1080/14779072.2016.1217154

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…However, despite the research efforts detailed above, the SynCardia TAH, which is the evolution of the Jarvik 7 then renamed CardioWest, still is the only device currently FDA‐approved for total cardiac replacement . This device has been implanted in almost 2,000 patients, in part due to a current smaller (50‐cc) system for adolescents and children, despite its difficult long‐term durability due to the finite cyclic endurance of the flexible membranes .…”

Section: Biosketchmentioning

confidence: 99%

“…Recently, Dr. Alain Carpentier, in collaboration with European Aerospace and Defense Systems, introduced the pulsatile Carmat TAH which uses bovine pericardium for its blood‐contacting surfaces making it almost “biological” which should be a further the ideal concept in mechanical circulatory support .…”

Section: Biosketchmentioning

confidence: 99%

“…Finally, at THI, Dr. Daniel Timms and colleagues have made substantial progress in developing a promising continuous‐flow TAH which has been named BiVACOR . It balances pulmonary and systemic blood flow automatically, using a zero‐power magnetic suspension system that levitates a single, double‐sided impeller.…”

Section: Biosketchmentioning

confidence: 99%

“…So far, only large animal trials have been initiated. Another continuous flow TAH project is still ongoing at the Cleveland Clinic .…”

Section: Biosketchmentioning

confidence: 99%

“…However, despite all encouraging results of technology evolution and the current knowledge/management of induced mechanical circulatory support physiology, as above mentioned, the Achilles' heel of implantable mechanical circulatory support devices still remains the absence of a satisfactory biocompatibility with consequent thromboembolic events and the presence of a percutaneous driveline which leads to high risk of infective disorders and represents a real barrier to the long‐term application of VADs and TAHs in terms of definitive therapies .…”

Section: Biosketchmentioning

confidence: 99%

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Heart Replacement Therapy: Biological, Mechanical or Regenerative?

Loforte

2018

Artificial Organs

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Section: Biosketchmentioning

confidence: 99%

Section: Biosketchmentioning

confidence: 99%

Section: Biosketchmentioning

confidence: 99%

“…So far, only large animal trials have been initiated. Another continuous flow TAH project is still ongoing at the Cleveland Clinic .…”

Section: Biosketchmentioning

confidence: 99%

Section: Biosketchmentioning

confidence: 99%

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Heart Replacement Therapy: Biological, Mechanical or Regenerative?

Loforte

2018

Artificial Organs

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Intrinsic Heart Regeneration in Adult Vertebrates May be Strictly Limited to Low‐Metabolic Ectotherms

et al. 2020

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The heart has a high-metabolic rate, and its "around-the-clock" vital role to sustain life sets it apart in a regenerative setting from other organs and appendages. The landscape of vertebrate species known to perform intrinsic heart regeneration is strongly biased toward ectotherms-for example, fish, salamanders, and embryonic/neonatal ectothermic mammals. It is hypothesized that intrinsic heart regeneration is exclusively limited to the low-metabolic hearts of ectotherms. The biomedical field of regenerative medicine seeks to devise biologically inspired regenerative therapies to diseased human hearts. Falsification of the ectothermy dependency for heart regeneration hypothesis may be a crucial prerequisite to meaningfully seek inspiration in established ectothermic regenerative animal models. Otherwise, engineering approaches to construct artificial heart components may constitute a more viable path toward regenerative therapies. A more strict definition of regenerative phenomena is generated and several testable sub-hypotheses and experimental avenues are put forward to elucidate the link between heart regeneration and metabolism. Also see the video abstract here https://youtu.be/fZcanaOT5z8.

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Design and Analysis of a 16/6 Bearingless Switched Reluctance Motor with Segment Hybrid Rotor Teeth

Sun

Zhuang

et al. 2020

IEEJ Transactions Elec Engng

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In this article, a 16/6 bearingless switched reluctance motor (BSRM) with segment hybrid rotor teeth has been presented. To realize the decoupling control of torque and suspension force, the rotor teeth were divided into three torque teeth and three suspension teeth, and both of them are embedded in support part. First, both torque and suspension force are generated by short-circuit excitation, the flux linkage coupling between torque windings and suspension windings was eliminated, and the separate control of torque and suspension force was achieved. Then, by increasing the pole arc of suspension teeth, the inductance of suspension windings is kept constant, which eliminates the influence on the output torque when adjusting suspension force. Finally, the coupling degree is further reduced by using nonmagnetic material as the supporting part. In addition, to achieve a greater output torque, the torque teeth are processed into U-shape and optimized the pole arc of stator teeth and rotor teeth. The characteristics of inductance, flux linkage, and output torque are analyzed by the finite-element method, and the results show that the proposed structure basically achieves the decoupling control of torque and suspension force. (Non-member) was born in 1996, Rizhao, China.He received the B.S. degree in measurement and control technology and instrument from Shandong University of Science and Technology. His research interests include magnetic suspension artificial heart, precision instrumentation design, and system control.Jingkai Li (Non-member) was born in 1990, Zaozhuang, China. He graduated in measurement and control technology and instrument from Shandong University of Science and Technology. He is currently pursuing the M.S. degree in system control and automation instrumentation. His research interests include magnetic suspension artificial heart, magnetic suspension control system and sensorless detection of bearingless switched reluctance motor.Jiaqing Li (Non-member) was born in 1996, Jining, China.He received the B.S. degree in mechanical design manufacture and automation major from Zaozhuang University, and he is currently pursuing the M.S. degree in mechanical engineering. His research interests include advanced manufacturing technology and precision instrumentation.

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Previous challenges and current progress–the use of total artificial hearts in patients with end-stage heart failure

Cited by 9 publications

References 14 publications

Heart Replacement Therapy: Biological, Mechanical or Regenerative?

Heart Replacement Therapy: Biological, Mechanical or Regenerative?

Intrinsic Heart Regeneration in Adult Vertebrates May be Strictly Limited to Low‐Metabolic Ectotherms

Design and Analysis of a 16/6 Bearingless Switched Reluctance Motor with Segment Hybrid Rotor Teeth

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