PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

Fogelholm, Mikael; Larsen, Thomas Meinert; Westerterp-Plantenga, Margriet S.; Macdonald, I. A.; Martínez, J. Alfredo; Boyadjieva, Nadka; Poppitt, Sally D.; Schlicht, Wolfgang; Stratton, Gareth; Sundvall, Jouko; Lam, TH; Jalo, Elli; Christensen, Pia; Drummen, Mathijs; Simpson, Elizabeth; Navas-Carretero, Santiago; Handjieva‐Darlenska, Teodora; Muirhead, Roslyn; Silvestre, Marta P.; Kahlert, Daniela; Pastor-Sanz, L.; Brand-Miller, Jennie; Raben, Anne

doi:10.3390/nu9060632

Cited by 78 publications

(120 citation statements)

References 43 publications

Supporting

Mentioning

118

Contrasting

Order By: Relevance

“…The initial more restricted phase may be useful in promptly achieving targets for body weight, glycaemic control and/or nutritional ketosis to motivate patients to sustain behaviour change(s). A similar two‐phase approach was used in a large‐scale, multinational T2D prevention trial . The prescription included a very‐low‐calorie diet (~800 kcal/d) during an initial weight‐reduction phase to achieve >8% initial body weight loss before moving to a more flexible weight‐maintenance phase .…”

Section: Discussionmentioning

confidence: 99%

An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods

Turton

Brinkworth

Field

et al. 2019

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

Aim To identify core diet and delivery components of low‐carbohydrate (CHO) diets that have demonstrated efficacy for type 2 diabetes (T2D) management. Materials and methods MEDLINE, Pre‐MEDLINE, EMBASE, CINAHL and the Cochrane Library of Controlled Trials databases were systematically searched from inception until August 18, 2018. Primary intervention studies of low‐CHO diets (≤130 g/d or 26% total energy intake [TEI]) were included. Content analysis was performed on the low‐CHO diet protocols classified as safe and effective for T2D management. Results A total of 41 studies published between 1963 and 2018 were included, of which 40 were classified as safe and effective for inclusion in the primary analysis. Thirteen studies (13/40) were on very‐low‐CHO diets (<50 g/d), 14/40 included low‐CHO diets (≤130 g/d or 26% TEI), and 13/40 were adapted according to participant progress. Thirty‐one studies reported a total energy prescription, of which 18/31 encouraged ad libitum intakes. Twenty studies reported a prescribed dietary fat amount, of which 18/20 were unrestricted or high‐fat (>35% TEI). Twenty‐six studies reported a prescribed dietary protein amount, of which 22 were unrestricted or were high‐protein (>25% TEI). The types of dietary CHO, fat and protein recommended were predominantly whole foods. Common delivery methods reported were dietician and/or physician involvement, moderate to high frequency of contact (≥1 session/month) and use of participant self‐monitoring. Conclusions Multiple approaches for developing and delivering a low‐CHO diet intervention for T2D management are safe and effective. A comprehensive set of core dietary components to consider in the formulation of low‐CHO diet protocols were identified for use in clinical practice and to inform evidence‐based guidelines for T2D management.

show abstract

Section: Discussionmentioning

confidence: 99%

An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods

Turton

Brinkworth

Field

et al. 2019

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

show abstract

“…This study is a cross-sectional analysis of the baseline data from the PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World (PREVIEW) study. PREVIEW is registered with ClinicalTrials.gov (NCT01777893) and a detailed protocol has been published elsewhere [20].…”

Section: Participants and Settingmentioning

confidence: 99%

“…A detailed description of the recruitment and screening process has been published previously [20]. Briefly, participants were recruited using varied methods across the 8 study sites which included newspaper, radio and television advertisements and direct contact with primary and occupational health care providers.…”

Section: Participants and Settingmentioning

confidence: 99%

Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis

Swindell

Rees

Fogelholm

et al. 2020

Int J Behav Nutr Phys Act

Self Cite

View full text Add to dashboard Cite

Background: Physical activity, sedentary time and sleep have been shown to be associated with cardio-metabolic health. However, these associations are typically studied in isolation or without accounting for the effect of all movement behaviours and the constrained nature of data that comprise a finite whole such as a 24 h day. The aim of this study was to examine the associations between the composition of daily movement behaviours (including sleep, sedentary time (ST), light intensity physical activity (LIPA) and moderate-to-vigorous activity (MVPA)) and cardio-metabolic health, in a cross-sectional analysis of adults with pre-diabetes. Further, we quantified the predicted differences following reallocation of time between behaviours. Methods: Accelerometers were used to quantify daily movement behaviours in 1462 adults from eight countries with a body mass index (BMI) ≥25 kg·m − 2 , impaired fasting glucose (IFG; 5.6-6.9 mmol·l − 1 ) and/or impaired glucose tolerance (IGT; 7.8-11.0 mmol•l − 1 2 h following oral glucose tolerance test, OGTT). Compositional isotemporal substitution was used to estimate the association of reallocating time between behaviours. (Continued on next page)Results: Replacing MVPA with any other behaviour around the mean composition was associated with a poorer cardio-metabolic risk profile. Conversely, when MVPA was increased, the relationships with cardiometabolic risk markers was favourable but with smaller predicted changes than when MVPA was replaced. Further, substituting ST with LIPA predicted improvements in cardio-metabolic risk markers, most notably insulin and HOMA-IR.Conclusions: This is the first study to use compositional analysis of the 24 h movement composition in adults with overweight/obesity and pre-diabetes. These findings build on previous literature that suggest replacing ST with LIPA may produce metabolic benefits that contribute to the prevention and management of type 2 diabetes. Furthermore, the asymmetry in the predicted change in risk markers following the reallocation of time to/from MVPA highlights the importance of maintaining existing levels of MVPA.Trial registration: ClinicalTrials.gov (NCT01777893).

show abstract

“…The aim was to induce weight loss of at least 8%, in order to qualify for inclusion in the randomized intervention where the focus is on longterm weight loss maintenance. 4 The majority of individuals who use weight loss programmes, including bariatric surgery, are women. 5,6 Investigating whether outcomes differ between men and women is import in developing gender-specific treatment programmes, if required.…”

Section: Introductionmentioning

confidence: 99%

Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi‐centre intervention study after a low‐energy diet in 2500 overweight, individuals with pre‐diabetes (PREVIEW)

Christensen

Larsen

Westerterp-Plantenga

et al. 2018

Diabetes Obesity Metabolism

Self Cite

122

View full text Add to dashboard Cite

AimsThe PREVIEW lifestyle intervention study (http://clinicaltrials.gov Identifier: NCT01777893) is, to date, the largest, multinational study concerning prevention of type‐2 diabetes. We hypothesized that the initial, fixed low‐energy diet (LED) would induce different metabolic outcomes in men vs women.Materials and methodsAll participants followed a LED (3.4 MJ/810 kcal/daily) for 8 weeks (Cambridge Weight Plan). Participants were recruited from 8 sites in Europe, Australia and New Zealand. Those eligible for inclusion were overweight (BMI ≥ 25 kg/m2) individuals with pre‐diabetes according to ADA‐criteria. Outcomes of interest included changes in insulin resistance, fat mass (FM), fat‐free mass (FFM) and metabolic syndrome Z‐score.ResultsIn total, 2224 individuals (1504 women, 720 men) attended the baseline visit and 2020 (90.8%) completed the follow‐up visit. Following the LED, weight loss was 16% greater in men than in women (11.8% vs 10.3%, respectively) but improvements in insulin resistance were similar. HOMA‐IR decreased by 1.50 ± 0.15 in men and by 1.35 ± 0.15 in women (ns). After adjusting for differences in weight loss, men had larger reductions in metabolic syndrome Z‐score, C‐peptide, FM and heart rate, while women had larger reductions in HDL cholesterol, FFM, hip circumference and pulse pressure. Following the LED, 35% of participants of both genders had reverted to normo‐glycaemia.ConclusionsAn 8‐week LED induced different effects in women than in men. These findings are clinically important and suggest gender‐specific changes after weight loss. It is important to investigate whether the greater decreases in FFM, hip circumference and HDL cholesterol in women after rapid weight loss compromise weight loss maintenance and future cardiovascular health.

show abstract

PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial

Cited by 78 publications

References 43 publications

An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods

An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods

Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: cross-sectional baseline analysis

Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi‐centre intervention study after a low‐energy diet in 2500 overweight, individuals with pre‐diabetes (PREVIEW)

Contact Info

Product

Resources

About