Preventive Strategies for Management of COVID-19 Using Natural Molecules

Abstract

The COVID19, a fatal disease by coronavirus (SARS-CoV-2) in late 2019 in China is now pandemic caused severe acute respiratory syndrome. The pandemic of COVID-19 has reached almost all regions of the world including territories with the death toll of more than 35,000. It has been estimated that one out every six-person affected by COVID-19 developed life-threatening conditions. The difficulty is that there are no vaccines or no specific treatment modalities for the management of COVID-19, apart from symptomatic treatments. Efforts for the development of vaccines and other specific treatment modalities are co-ordinated by the World Health Organisation (WHO), with many clinical trials ongoing with modern and traditional medicines. In this regard, various Phyto-actives from the plants are getting analyzed, which has earlier shown to be effective in various viral infections. Therefore, keeping the world scenario and due to the lack of vaccine, we have in silico studied the activity of tetrahydrocurcumin, a major metabolite of curcumin, a household spice, matairesinol, a major compound in wheat bran or flaxseed and vitamin K2-7 against both SARS-CoV's main peptide and COVID-19 Mpro.

Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation

“…11 Our published molecular docking studies clearly indicated that curcumin can bind to the receptors and inhibit ACE2, thus blocking the entry of COVID-19 virus. 27 Vitamin K2-7 is effective in reducing pro inflammatory cytokines. Selenomethionine is a natural form of Selenium (Se) which plays a critical role in prevention of infection.…”