Preventive screening of colorectal cancer with a device based on chemoresistive sensors

Zonta, Giulia; Anania, Gabriele; Fabbri, Barbara; Gaiardo, Andrea; Gherardi, S.; Giberti, A; Landini, Nicolò; Malagù, C.; Scagliarini, Lucia; Guidi, V.

doi:10.1016/j.snb.2016.07.079

Cited by 22 publications

(23 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This depends on the fact that smaller and less aggressive tumors emanate smaller quantities of different metabolites and VOCs when compared to more aggressive or bigger neoplasms, as was proven in both the histological exam (which confirmed the different size and aggressiveness of the tumoral formations) and by comparison with ST25 650+Au, which instead could distinguish them as the less polluting cancers for the circulatory system by their mere observed responses. This is a huge confirmation of the work carried out on these particular sensors, since those materials were explicitly chosen from the assessments that the team could finalize from previous works [1][2][3][4][5][6][7], sealing the reliability of some semiconductors for neoplasms screening in vitro applications.…”

Section: Discussionmentioning

confidence: 88%

“…The variety of sensors chosen lays upon the will to verify if chemoresistive sensors can detect variations as a whole technology, or if only some particular semiconductors can be used for screening/detection purposes, and to visualize possible correlations between their response behaviors. Further details in the sensors' functioning, the differences between the various semiconductor materials, and their characterizations can be found in literature [1][2][3][4][5][6][7][33][34][35][36][37][38][39][40][41][42][43][44][45]. The responses are standardly defined as the average value between three output voltages measured by the sensor from the same sample, as shown in the following formula [6]:…”

Section: Sensors Technologymentioning

confidence: 99%

“…Chemoresistive semiconductor sensors, fast responding devices commonly used for pollution and alimentary screening, could be the brand-new choice of sensing units for medical devices aimed at Sensors 2020, 20, 1411 2 of 15 this kind of approach, as multiple studies have proved their usefulness for screening applications on different biological samples [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Landini

Anania

Astolfi

et al. 2020

Sensors

Self Cite

View full text Add to dashboard Cite

Preventive screening does not only allow to preemptively intervene on pathologies before they can harm the host; but also to reduce the costs of the intervention itself; boosting the efficiency of the NHS (National Health System) by saving resources for other purposes. To improve technology advancements in this field; user-friendly yet low-cost devices are required; and various applications for gas sensors have been tested and proved reliable in past studies. In this work; cell cultures and blood samples have been studied; using nanostructured chemoresistive sensors; to both verify if this technology can reliably detect tumor markers; and if correlations between responses from tumor line metabolites and the screening outcomes on human specimens could be observed. The results showed how sensors responded differently to the emanations from healthy and mutant (for cells) or tumor affected (for blood) samples, and how those results were consistent between them, since the tumoral specimens had higher responses compared to the ones of their healthy counterparts. Even though the patterns in the responses require a bigger population to be defined properly; it appeared that the different macro-groups between the same kind of samples are distinguishable from some of the sensors chosen in the study; giving promising outcomes for further research.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Sensors Technologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Landini

Anania

Astolfi

et al. 2020

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, methods based on principal component analysis (PCA) have also proven its capability to build WT fault detection strategies [7], [3], [8]. However, QDA is most commonly used in medicine [9], [10] and genomics [11], [12], as a classifier or as a pattern-recognition method. A recent application of QDA in WT fault detection is proposed by [13] where an approach for detecting and diagnosing the delamination in wind turbine blades is proposed.…”

Section: Introductionmentioning

confidence: 99%

Damage diagnosis for offshore ﬁxed wind turbines

Agis¹,

Vidal²,

Pozo³

2019

REPQJ

View full text Add to dashboard Cite

This paper proposes a damage diagnosis strategy to detect and classify different type of damages in a laboratory offshore-fixed wind turbine model. The proposed method combines an accelerometer sensor network attached to the structure with a conceived algorithm based on principal component analysis (PCA) with quadratic discriminant analysis (QDA).The paradigm of structural health monitoring can be undertaken as a pattern recognition problem (comparison between the data collected from the healthy structure and the current structure to diagnose given a known excitation). However, in this work, as the strategy is designed for wind turbines, only the output data from the sensors is used but the excitation is assumed unknown (as in reality is provided by the wind).The proposed methodology is tested in an experimental laboratory tower modeling an offshore-fixed jacked-type wind turbine. The obtained results show the reliability of the proposed approach.

show abstract

“…Gas sensors represent crucial elements in gas monitoring systems and olfactory systems for several applications: environmental monitoring, safety and security, quality control of food production, medical diagnosis and so on [2]. From the point of view of the gas sensing design, the substrate plays a fundamental role, because it acts as a heater, mechanical support and transducer of the sensor response.…”

mentioning

confidence: 99%

On the Optimization of a MEMS Device for Chemoresistive Gas Sensors

Gaiardo

Fabbri

Valt

et al. 2017

Proceedings of the 5th International Symposium on Sensor Science (I3S 2017)

View full text Add to dashboard Cite

In recent years, research in the gas sensor field has experienced a significant boost [1]. Gas sensors represent crucial elements in gas monitoring systems and olfactory systems for several applications: environmental monitoring, safety and security, quality control of food production, medical diagnosis and so on [2]. From the point of view of the gas sensing design, the substrate plays a fundamental role, because it acts as a heater, mechanical support and transducer of the sensor response. The application of MEMS technology for the fabrication of a silicon device with very low power consumption has offered new opportunities for innovative gas sensor design. In this work, we studied different approaches in order to realize an adapt silicon microheaters for chemiresistive gas sensors, available for high operating temperatures (650°C) through MEMS technology. In order to assess a reliable microdevice for this application field, in this work, we studied the different processing steps required to obtain a silicon microheater: layout of the device, types of metals used as a heater and interdigitated contacts, type of insulator and heat treatment to be adopted during the microfabrication. Finally, we propose the processing that provided the best results. Conflicts of Interest:The authors declare no conflict of interest.

show abstract

Preventive screening of colorectal cancer with a device based on chemoresistive sensors

Cited by 22 publications

References 12 publications

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Damage diagnosis for offshore ﬁxed wind turbines

On the Optimization of a MEMS Device for Chemoresistive Gas Sensors

Contact Info

Product

Resources

About