Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia

Abstract

BackgroundDuring the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including obesity, hypercholesterolemia and diabetes. In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi-Men) against lifestyle related disorders.MethodsFunctional drinks (T2 and T3) were prepared by adding catechins and epigallocatechin gallate (EGCG) @ 550 mg/500 mL and compared with control (T1). These functional drinks were tested in experimental rats modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high cholesterol diet), trial-III (high sucrose diet), trial-IV (high cholesterol + high sucrose diet). Rats were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56 days rats were sacrificed and evaluated their serum lipid (cholesterol, LDL and HDL), glucose and insulin levels.ResultsResults for feed consumption by rats revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, cholesterol and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum glucose and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing EGCG reduced the trait better than catechins based functional drink.ConclusionsThe drinks supplemented with catechins and EGCG are effective against obesity, hypercholesterolemia and hyperglycemia.

Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome

“…Then, it has been noted that treatment with 50 mg/kg EGCG for 60 days is able to decrease adipose tissue, triglycerides and HDL-cholesterol only in high-fat diet mice [ 110 ]. The preventive role of EGCG from hypercholesterolemia has been described in a recent study [ 111 ] conducted on Sprague Dawley rats treated with 550 mg/500 mL EGCG. Furthermore, cholesterol and LDL have been reduced by drink containing EGCG in comparison with control drinks.…”

EGCG exerts its protective effect by mitigating the release of lysosomal enzymes in aged rat liver on exposure to high cholesterol diet

“…The increase in the LDL receptor improves the uptake of LDL from the blood circulation. Moreover, reduced expression of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMGR) might be another reason for hypocholesterolemic activity of green tea . Green tea catechins also increase the bile acid excretion by preventing reabsorption from small intestine through disruption of micelle formation of bile acids.…”

Protective Effects of Green Tea and Moringa Leave Extracts and Their Bio-Yoghurts against Oxidative Effects of Lead Acetate in Albino Rats

“…More recently the protective role of green tea catechins against obesity and associated disorders i.e hypercholesterolemia and hyperglycemia was studied in rats [81]. The total cholesterol and LDL-cholesterol were considerably reduced by 14.42% in high cholesterol + high sucrose diet and 30.43% in high cholesterol diet, respectively.…”