Preventive Nephrology - Proposed Options in Childhood Nephropathy

Adedoyin, OT

doi:10.4314/njp.v28i2.12056

Cited by 3 publications

(5 citation statements)

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“…At present the initiation and maintenance of dialysis therapy in a Nigerian child with ARF or CRF is frustrating and problematic due to the lack of facilities due to economic constraints. It was proposed that an inexpensive option to improve renal health in developing countries would be the extension of preventive nephrology that would no doubt reduce morbidity and mortality from RF due to preventable diseases [16]. Kidney disorders subject to preventive measures in Nigerian children include acute glomerulonephritis due to b-hemolytic streptococcal infection, hemolytic uremic syndrome, nephrotic syndrome due to Plasmodium malariae, and non-renal causes of ARF such as gastroenteritis, septicemia, P falciparum infection, and intravascular hemolysis due to glucose-6-phosphate dehydrogenase deficiency [5,23,24,25].…”

Section: Discussionmentioning

confidence: 99%

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Renal failure in Nigerian children: factors limiting access to dialysis

Olowu

2003

Pediatric Nephrology

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A 5-year clinical and laboratory study of Nigerian children with renal failure (RF) was performed to determine the factors that limited their access to dialysis treatment and what could be done to improve access. There were 48 boys and 33 girls (aged 20 days to 15 years). Of 81 RF patients, 55 were eligible for dialysis; 33 indicated ability to afford dialysis, but only 6 were dialyzed, thus giving a dialysis access rate of 10.90% (6/55). Ability to bear dialysis cost/dialysis accessibility ratio was 5.5:1 (33/6). Factors that limited access to dialysis treatment in our patients included financial restrictions from parents (33%), no parental consent for dialysis (6%), lack or failure of dialysis equipment (45%), shortage of dialysis personnel (6%), reluctance of renal staff to dialyze (6%), and late presentation in hospital (4%). More deaths were recorded among undialyzed than dialyzed patients ( P<0.01); similarly, undialyzed patients had more deaths compared with RF patients who required no dialysis ( P<0.025). Since most of our patients could not be dialyzed owing to a range of factors, preventive nephrology is advocated to reduce the morbidity and mortality from RF due to preventable diseases.

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Section: Discussionmentioning

confidence: 99%

“…Poverty precluded dialysis therapy in at least a third of our patients; it is a major factor limiting access to renal healthcare in Nigeria [16,17] and also a recognized cause of discharge against medical advice [18,19].…”

Section: Discussionmentioning

confidence: 99%

Renal failure in Nigerian children: factors limiting access to dialysis

Olowu

2003

Pediatric Nephrology

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“…The profile of paediatric renal disease has been studied in some parts of the developing world. [2][3][4][5] The management of chronic renal disorders and their long-term consequences are currently beyond the scope of most of the resource-poor countries like Nigeria. This underscores the importance of early diagnosis and treatment of these conditions before they get to the chronic state.…”

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confidence: 99%

“…The pattern of diseases recorded in this study is similar to that observed by other workers within and outside Nigeria. [3][4][5] Acute glomerulonephritis is the commonest renal disorder in this study followed by nephrotic syndrome. This agrees with some studies within the country and is at variance with others.…”

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confidence: 99%

Pattern of paediatric renal disease in inpatients in Calabar, Nigeria

Etuk¹,

Anah²,

Ochighs³

et al. 2006

Trop Doct

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“…Activated T helper 2 (Th2) cells produce two main cytokines, IL-4 and IL-13, that induce class switching from IgG to IgE production. 4 Indeed, some studies have revealed a strong relationship between SSNS and atopy accompanied by high serum levels of IgE antibodies. 5 Furthermore, IL-13 was found to induce proteinuria in MCNS patients through direct upregulation of CD80 expression on the podocyte.…”

Section: Introductionmentioning

confidence: 99%

Serum immunoglobulin E level in children with nephrotic syndrome

Ali

Al-Shawi

Hiris

2022

Baghdad J. Biochem. Appl. Biol. Sci.

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Background and objective: The most supported theory for Nephrotic Syndrome (NS) etiology is that it is immune-mediated. This study aims to assess the level of serum IgE in children with Steroid Sensitive NS (SSNS) at relapse and remission, and its correlation with the presence of atopy. Methods: This cross-sectional study was approved by the Department of Pediatrics, College of Medicine, Al-Nahrain University (Baghdad, Iraq) and conducted at Al-Imamain Al-Kadhimain Medical City (Baghdad, Iraq), and Child Central Teaching Hospital (Baghdad, Iraq), and included 31 children SSNS. The data collected was: age, sex, residency, onset of NS, response to steroid, frequency of relapses, and the history of atopy of the patient and his relatives. Serum IgE level was measured during relapse for all patients and for 9 patients while in remission. Results: Atopy was present in 18 (58.06%) of patients. The median serum IgE level was 295.5 IU/mL (range 54-2864 IU/mL) in relapse, which is significantly higher (P-value =0.006) than in remission 228.5 IU/mL (range 62-2069 IU/mL). Median serum level of IgE in patients with atopy was 290.5 IU/mL (range 24-2864 IU/mL) which was higher than that of patients without atopy (median 231 IU/mL, range 23-1314 IU/m) (P-value = 0.029). Patients required longer period to respond to steroid therapy (>10 days) had a significantly higher median of IgE (341 IU/mL) than those who required <10 days to respond (161 IU/mL) (P-value =0.045). Conclusions: Increased IgE level is documented during relapse and in atopic children with SSNS. Longer duration to respond to steroid therapy is associated significantly with higher serum IgE during relapse.

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Preventive Nephrology - Proposed Options in Childhood Nephropathy

Cited by 3 publications

References 0 publications

Renal failure in Nigerian children: factors limiting access to dialysis

Renal failure in Nigerian children: factors limiting access to dialysis

Pattern of paediatric renal disease in inpatients in Calabar, Nigeria

Serum immunoglobulin E level in children with nephrotic syndrome

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