Abstract:In this paper we present our experience on the treatment at home of Covid+ symptomatic patients. One hundred and eighty-two subjects (111 men and 71 women) aged from 32 to 71 years have been consecutively followed at home in telemedicine from 1st September to 24th December 2020. We were informed almost twice daily in morning and evening about body temperature, symptoms (cough, shortness of breath or difficulty breathing, fatigue, muscle of body aches, headache, loss of taste or smell, sore throat, congestion o… Show more
“… 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 One study was excluded owing to reporting irrelevant outcomes, focusing on therapeutic options with less emphasis on the RPM model. 43 Figure 2 PRISMA diagram showing the study selection process …”
“… 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 One study was excluded owing to reporting irrelevant outcomes, focusing on therapeutic options with less emphasis on the RPM model. 43 Figure 2 PRISMA diagram showing the study selection process …”
“…Early administration of antithrombotic agents such as low-molecular-weight heparin (LMWH), direct orally active factor Xa inhibitors (apixaban, rivaroxaban), or sulodexide to patients at risk of disease worsening reduces the risk of hospitalization, need for oxygen support, or even mortality. 112 113 114 115 116 117 Nevertheless, particularly for LMWHs, the optimal dose needs to be thoroughly evaluated. 118 The organization of the necessary framework for home-based medical care will be of major importance for the optimal administration of the forthcoming specific antiviral treatments which are currently under investigation or clinical development.…”
One year after the declaration of the COVID-19 pandemic by the World Health Organization (WHO) and despite the implementation of mandatory physical barriers and social distancing, humanity remains challenged by a long-lasting and devastating public health crisis.
Non-pharmacological interventions (NPI) are efficient mitigation strategies. The success of these intense NPI is dependent on the approval and commitment of the population. The launch of a mass vaccination program in many countries in late December 2020 with mRNA vaccines, adenovirus-based vaccines, and inactivated virus vaccines has generated hope for the end of the pandemic.
Current issues: The continuous appearance of new pathogenic viral strains and the ability of vaccines to prevent infection and transmission raise important concerns as we try to achieve community immunity against SARS-CoV-2 and its variants. The need of a second and even third generation of vaccines and the possibility of potentially harmful side-effects of the vaccines (i.e. venous thromboembolism ) have already been acknowledged.
Perspectives: There is a critical and urgent need for a balanced and integrated strategy for the management of the COVID-19 outbreaks organized on three axes: (1) Prevention of the SARS-CoV-2 infection, (2) Detection and early diagnosis of patients at risk of disease worsening, and (3) Anticipation of medical care (PDA).
Conclusion: The “PDA strategy” integrated into state policy for the support and expansion of health systems and introduction of digital organization (i.e. telemedicine, artificial intelligence and machine learning technology) is of major importance for the preservation of citizens’ health and life world-wide.
“…It generated controversial issues and great concerns even on authorized and agreed therapeutic protocols for SARS-CoV2 pandemic, particularly in people staying at home with early symptoms of COVID-19. [1][2][3][4] From a pathogenetic point of view, COVID-19 is a clinical syndrome caused by an infection associated with a severe acute respiratory syndrome (ARDS) from SARS-CoV-2, essentially due to damage to the lung functionality. ARDS is most probably caused by a progressive disruption of the barrier integrity in endothelia, therefore causing a diffuse lung damage.…”
Section: Introduction On the Immuno-thrombotic Etiopathogenesis Of Co...mentioning
confidence: 99%
“…The coronavirus disease 2019 (COVID‐19) had a huge impact on health management worldwide. It generated controversial issues and great concerns even on authorized and agreed therapeutic protocols for SARS‐CoV2 pandemic, particularly in people staying at home with early symptoms of COVID‐19 1–4 . From a pathogenetic point of view, COVID‐19 is a clinical syndrome caused by an infection associated with a severe acute respiratory syndrome (ARDS) from SARS‐CoV‐2, essentially due to damage to the lung functionality.…”
Section: Introduction On the Immuno‐thrombotic Etiopathogenesis Of Co...mentioning
confidence: 99%
“…This engulfed a huge need of medical expertise and caregivers, often subtracting people from having an available consultancy at home or at their disposal. In this perspective, suggestions and recommendations were even reported elsewhere in the literature, 1,4 despite some critical comment 17–20 . The fundamental role of a home protocol to address mild COVID‐19 or the early symptoms of this pathology is to ensure a rapid pharmacological intervention in order to absolutely prevent hospitalization, often due to exacerbation more than excessive caution.…”
Section: Introduction On the Immuno‐thrombotic Etiopathogenesis Of Co...mentioning
The COVID-19 pandemic is a highly dramatic concern for mankind. In Italy, the pandemic exerted its major impact throughout the period of February to June 2020. To date, the awkward amount of more than 134,000 deaths has been reported. Yet, post-mortem autopsy was performed on a very modest number of patients who died from COVID-19 infection, leading to a first confirmation of an immune-thrombosis of the lungs as the major COVID-19 pathogenesis, likewise for SARS. Since then (June-August 2020), no targeted early therapy considering this pathogenetic issue was approached. The patients treated with early anti-inflammatory, anti-platelet, anticoagulant and antibiotic therapy confirmed that COVID-19 was an endothelial inflammation with immuno-thrombosis. Patients not treated or scarcely treated with the most proper and appropriate therapy and in the earliest, increased the hospitalization rate in the intensive care units and also mortality, due to immunethrombosis from the pulmonary capillary district and alveoli. The disease causes widespread endothelial inflammation, which can induce damage to various organs and systems. Therapy must be targeted in this consideration, and in this review, we demonstrate how early anti-inflammatory therapy may treat endothelia inflammation and immune-thrombosis caused by COVID-19, by using drugs we are going to recommend in this paper.
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