Preventive Efficiency of Chelidonium majus Ethanolic Extract Against Aflatoxin B1 Induced Neurochemical Deteriorations in Rats

Kasem, Naglaa R. A.; Mannaa, Fathia A.; Abdel-Wahhab, Khaled G.; Mourad, Hagar H; Gomaa, Heba F.

doi:10.3923/pjbs.2022.234.244

Cited by 7 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, studies have found that several extracts of traditional Chinese medicine (including Artichoke leaf extract, Chelidonium majus ethanolic extract [CMEE], Pumpkin extract, and Crocus sativus L. tea) could provide neuroprotective effects against AFB1-induced neurotoxicity in mice or rats (15,28,29,31,81). Ibrahim et al found oral supplementation of artichoke leaf extract at 100 mg/kg for 42 days could inhibit AFB1-induced neurotoxicity in rats by increasing the levels of antioxidant enzyme activities, as well as reversing lipidemia, augmented plasmatic glucose, and concentrations of insulin (29).Notably, dietary supplementation with artichoke leaf extract has been demonstrated to serve a protective role against AFB1-induced liver toxicity in rats via the inhibition of oxidative stress (97).…”

Section: Chinese Herbal Extractsmentioning

confidence: 99%

“…Ibrahim et al found oral supplementation of artichoke leaf extract at 100 mg/kg for 42 days could inhibit AFB1-induced neurotoxicity in rats by increasing the levels of antioxidant enzyme activities, as well as reversing lipidemia, augmented plasmatic glucose, and concentrations of insulin (29).Notably, dietary supplementation with artichoke leaf extract has been demonstrated to serve a protective role against AFB1-induced liver toxicity in rats via the inhibition of oxidative stress (97). Kasem et al found oral supplementation with CMEE at a dose of 300 mg/kg/day for 28 days could significantly inhibit AFB1-induced oxidative stress, inflammatory responses, apoptosis and reverse neurotransmitter depletion (e.g., AchE, dopamine, and 5-HT) (31). Alonso-Garrido et al showed Pumpkin extract (500 nmol/L) beneficially regulated the expression genes encoding mitochondrial complexes Ⅰ, Ⅳ and Ⅴ to improve AFT-induced mitochondrial dysfunction in human ECV 304 cells (81).…”

Section: Chinese Herbal Extractsmentioning

confidence: 99%

“…It has been reported that anti-oxidant foods and probiotic supplements (e.g. quercetin, curcumin, gallic acid, and dimethyl fumarate), Chinese herbal extracts (e.g., Artichoke leaf extract, Chelidonium majus ethanolic extract, Pumpkin extract, and Crocus sativus L. tea) could effectively inhibit ROS production, oxidative stress, mitochondrial dysfunction, inflammation, and cell apoptosis, helping counter some of the AFB1-induced neurobehavioral abnormalities and neurotoxicity (15,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents

Dai,

Tian,

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

Aflatoxins (AFTs) represent one of the most notorious classes of deadly mycotoxins produced by certain fungi that are found on agricultural crops. Aflatoxins are highly toxic to mammals and are known to cause a series of detrimental effects, including neuro-, hepato-, nephron-, and immuno-toxicity. In this original review we summarize the mechanisms of aflatoxin-induced neurotoxicity and the clinical potential of novel neuroprotective agents. Aflatoxin B1 (AFB1) is the most toxic congener among the 21 identified AFTs. Recent studies have shown that food borne exposure to AFB1 and/or its metabolites often leads to fatal neurotoxicity in animals and humans. Animal studies indicated that AFB1 exposure could induce abnormal behavioral changes, including anxiety, lethargy disorders, depression-like behavior, cognitive, learning and memory defects, and decreased feeding behavior. Mechanistically, AFB1 exposure has been associated with lipid peroxidation, ablation of non-enzymatic and enzymatic antioxidant defense systems and decreased neurotransmitter levels. AFB1 exposure has also been shown to induce DNA damage, apoptosis, pyroptosis, and mitochondrial dysfunction in the brain tissue. Several signaling pathways, including gasdermin D, toll like receptor 2 (TLR2), TLR4, Akt, NF-κB, ERK/MAPK, protein kinase C (PKC), and mitochondrial apoptotic pathways have been shown to participate in AFB1-induced neuronal or astrocyte cell death. Targeting these pathways by small molecules (e.g., quercetin, curcumin, and gallic acid, and dimethyl fumarate), Chinese herbal extracts (e.g., Artichoke leaf extract, Chelidonium majus ethanolic extract, Pumpkin extract, and Crocus sativus L. tea), and probiotic supplements could effectively improve AFB1-induced neurobehavioral abnormalities and neurotoxicity. To date, the precise molecular mechanisms of AFB1-induced neurotoxicity and potential neuroprotective agents remain unclear. In the present review, the clinical manifestations, molecular mechanisms, and potential neuroprotective agents of AFB1-induced neurotoxicity are summarized in the broadest overview. We are most hopeful that this broad reaching review provides valuable insights and stimulates broader discussion to develop the effective neuroprotective agents against aflatoxins.

show abstract

Section: Chinese Herbal Extractsmentioning

confidence: 99%

Section: Chinese Herbal Extractsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents

Dai,

Tian,

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

show abstract

“…AFB1 and 300 m/kg/b.w. PPs-rich ethanolic extract of Chelidonium majus (PEEC), the outcome showed that PEEC alleviated the neurochemical biomarkers ( 420 ). In AFB1-treated group, rats showed a significant increase in TNF-α, IL-1β and CD4, AChE, dopamine, and caspase 3 levels whereas co-treatment of PEEC (not PEEC alone) significantly alleviated the increased levels of studied neurochemical markers in rats' cortex and hippocampus areas, and improved the activity of antioxidant enzymes (GSH, SOD, CAT, GPx) ( 420 ).…”

Section: Pps Mechanism Of Actions For Improving Afs Complicationsmentioning

confidence: 99%

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

2022

View full text Add to dashboard Cite

The future GCC-connected environmental risk factors expedited the progression of nCDs. Indeed, the emergence of AFs is becoming a global food security concern. AFs are lethal carcinogenic mycotoxins, causing damage to the liver, kidney, and gastrointestinal organs. Long-term exposure to AFs leads to liver cancer. Almost a variety of food commodities, crops, spices, herbaceous materials, nuts, and processed foods can be contaminated with AFs. In this regard, the primary sections of this review aim to cover influencing factors in the occurrence of AFs, the role of AFs in progression of nCDs, links between GCC/nCDs and exposure to AFs, frequency of AFs-based academic investigations, and world distribution of AFs. Next, the current trends in the application of PPs to alleviate AFs toxicity are discussed. Nearly, more than 20,000 published records indexed in scientific databases have been screened to find recent trends on AFs and application of PPs in AFs therapy. Accordingly, shifts in world climate, improper infrastructures for production/storage of food commodities, inconsistency of global polices on AFs permissible concentration in food/feed, and lack of the public awareness are accounting for a considerable proportion of AFs damages. AFs exhibited their toxic effects by triggering the progression of inflammation and oxidative/nitrosative stress, in turn, leading to the onset of nCDs. PPs could decrease AFs-associated oxidative stress, genotoxic, mutagenic, and carcinogenic effects by improving cellular antioxidant balance, regulation of signaling pathways, alleviating inflammatory responses, and modification of gene expression profile in a dose/time-reliant fashion. The administration of PPs alone displayed lower biological properties compared to co-treatment of these metabolites with AFs. This issue might highlight the therapeutic application of PPs than their preventative content. Flavonoids such as quercetin and oxidized tea phenolics, curcumin and resveratrol were the most studied anti-AFs PPs. Our literature review clearly disclosed that considering PPs in antioxidant therapies to alleviate complications of AFs requires improvement in their bioavailability, pharmacokinetics, tissue clearance, and off-target mode of action. Due to the emergencies in the elimination of AFs in food/feedstuffs, further large-scale clinical assessment of PPs to decrease the consequences of AFs is highly required.

show abstract

In vitro and in vivo assessment of AFB1 and OTA toxic effects and the beneficial role of bioactive compounds. A systematic review

Frangiamone,

Lázaro,

Cimbalo

et al. 2024

Food Chemistry

View full text Add to dashboard Cite

Preventive Efficiency of Chelidonium majus Ethanolic Extract Against Aflatoxin B1 Induced Neurochemical Deteriorations in Rats

Cited by 7 publications

References 53 publications

Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents

Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

In vitro and in vivo assessment of AFB1 and OTA toxic effects and the beneficial role of bioactive compounds. A systematic review

Contact Info

Product

Resources

About