Preventive effects of standardized krill oil on alcohol hangovers in a clinical trial

Kim, Woo-Hyun; Lee, Hyun-Jeong; Lee, Da‐Yeon; Lee, Chan-Yang; Oh, Jeong-Ho; Kim, Jeongeun; Tan, Kiet Vu; Kang, Seoungki; Kim, Byungkwon; Hong, Seong-Bong; Yoon, Namkyu; Lee, Han-Joo; Shim, Soon‐Mi

doi:10.1016/j.jff.2022.105142

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However recent research suggests that systemic administration of alcohol and acetaldehyde can increase the accumulation of acetaldehyde in the blood and brain of mice [ 41 ]. A recent clinical trial that reported a correlation between acetaldehyde concentration and hangover symptom [ 42 , 43 , 44 , 45 , 46 , 47 ]. These were used a highly sensitive GC-MS method that reliably measures acetaldehyde concentrations [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Plant-Based Extract Mixture on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized, Double-Blind, Paralleled, Placebo-Controlled Clinical Trial

Jung

Lee

et al. 2023

JCM

View full text Add to dashboard Cite

Hangovers are uncomfortable physiological symptoms after alcohol consumption caused by acetaldehyde, a toxic substance in which alcohol is metabolized by alcohol dehydrogenase (ADH). Rapid alcohol and acetaldehyde decomposition are essential to alleviate alcohol handling symptoms. This study investigated the effects of HY_IPA combined with Mesembryanthemum crystallinum, Pueraria lobata flower, and Artemisia indica on alleviating hangovers. A randomized, double-blind, parallel-group, placebo-controlled clinical study was conducted on 80 individuals with hangover symptoms. Alcohol intake was 0.9 g/bw with 40% whiskey, adjusted proportionately to body weight. The Acute Hangover Scale total score was 5.24 ± 5.78 and 18.54 ± 18.50 in the HY_ IPA and placebo groups, respectively (p < 0.0001). All nine indicators of the hangover symptom questionnaire were significantly improved in the HY_IPA group (p < 0.01). Blood alcohol and acetaldehyde concentrations rapidly decreased from 30 min in the HY_IPA group (p < 0.05). ADH and acetaldehyde dehydrogenase (ALDH) activities in the blood of the HY_IPA group were significantly higher than those in the placebo group at 0, 1, and 2 h after alcohol consumption (p < 0.01). The rapid hangover relief was due to increased ADH and ALDH. Therefore, HY_IPA effectively relieves hangover symptoms by decomposing alcohol and acetaldehyde when consumed before alcohol consumption.

show abstract