Preventive effects of sevoflurane treatment on lung inflammation in rats

Shu-ye, Song; Zhou, Bing; Sai, Yang; Liu, Guoze; Tian, Jianmin; Xiu-qin, Yue

doi:10.1016/s1995-7645(12)60200-4

Cited by 14 publications

(15 citation statements)

References 10 publications

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“…Çalışmadan 12 saat önce sadece su içmeleri sağlandı. Benzer çalışmalar gözeti-lerek gruplar 7'şerli 3 gruba randomize olarak ayrıldı [9,10,11,14,15] . 1).…”

Section: Gereç Ve Yöntemunclassified

“…Bu çalışmalar incelendiğinde hasar görmüş akciğerlere sevofluran uygulanmasının TNFalfa, IL-6, ICAM-1, mRNA ekpresyonunu azalttığı, alveolar kapiller membran geçirgenliğini koruduğu, alveolo-epiteliyal hücrelerde nötrofil kemotaksisi, nötrofil adezyonu ve nötrofille indüklenen apoptozisi azalttığı, alveolar epitel hücrelerinin nekrozunu azalttığı görülmektedir. Hasarlı akciğerlerde sevofluranın iyileştirici etkisi mevcuttur [9,10,11,14,15,22,23] . Biz sağlıklı rat akciğerleri üzerinde çalışdık, çalıştığımız volatil anesteziklerden biri sevoflurandı.…”

Section: Via Işık Mikroskopisi: Hematoksilenandeosin Ile Boyama Sonucunclassified

“…Biz sağlıklı rat akciğerleri üzerinde çalışdık, çalıştığımız volatil anesteziklerden biri sevoflurandı. Çalışmamızın sonuçları bize sevofluranın izoflurana göre sağlıklı rat akciğerinde daha az alveoler hasara yol açtığını dü-şündürdü, çalışmamızın sonuçlarına paralel olarak literatürde de sevofluranın sağlıklı rat akciğeri üzerine inflamasyon yapıcı etkisinin daha az olduğu bildirilmiştir [9,10,18] . Tersine deneysel ve insan çalışmalarında sevofluranın hasarlı akciğer üzerinde iğleştirici etkisi olduğu bildirilmiştir.…”

Section: Via Işık Mikroskopisi: Hematoksilenandeosin Ile Boyama Sonucunclassified

“…Grup S, Grup İ ile karşılaştırıldığında alveoler ödem, alveoler septumlarda kalınlaşma, nötrofil ve tip II pnömositler daha az miktarda gözlendi (Resim 2, 3,4,8,9,10). Alveoler makrofaj sayısı ise Grup S de Grup İ ye göre istatistiksel olarak anlamlı miktarda azdı (Tablo 3) Parankim incelemesinde, Grup İ'de yoğun olarak görülen yaygın hemoraji, mononükleer hüc-re infiltrasyonu, ödem ve vasküler konjesyon daha az oranda saptandı (Resim 2, 3, 4, 8, 9, 10).…”

Section: Via Işık Mikroskopisi: Hematoksilenandeosin Ile Boyama Sonucunclassified

“…Yoğun inflamasyon apoptotik hücre ölümüyle ilişki-lendirilmiştir [5][6][7][8][9][10][11] . Apoptozis, süregen bir hücre intiharı olup, mekanizması tüm hücre nükleuslarındaki kromozomlarda şifrelenmiştir [12] .…”

Section: Introductionunclassified

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Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

Acıl¹,

Kaçar²,

Uzundere³

et al. 2018

GKDA Derg

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“…Çalışmadan 12 saat önce sadece su içmeleri sağlandı. Benzer çalışmalar gözeti-lerek gruplar 7'şerli 3 gruba randomize olarak ayrıldı [9,10,11,14,15] . 1).…”

Section: Gereç Ve Yöntemunclassified

Section: Via Işık Mikroskopisi: Hematoksilenandeosin Ile Boyama Sonucunclassified

Section: Introductionunclassified

See 3 more Smart Citations

Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

Acıl¹,

Kaçar²,

Uzundere³

et al. 2018

GKDA Derg

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Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Kotlińska-Hasiec

Nowicka-Stążka

Parada-Turska

et al. 2014

Arch. Immunol. Ther. Exp.

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Increases in plasma kynurenic acid (KYNA) concentration relate to the severity of inflammation. The aim of this study was to analyse changes in plasma KYNA concentration and neutrophil/lymphocyte ratio (NLR) in cardiac surgery patients. Additionally, the effect of anaesthesia was analysed. Adult cardiac surgery patients under intravenous general anaesthesia were studied. Additionally, some patients received sevoflurane (SEV) prior to cardiopulmonary bypass. Plasma KYNA concentration and NLR were measured before anaesthesia, just after surgery and on postoperative days 1, 2 and 3. Patients were assigned to two groups: patients who did not receive SEV (NonSEV group) and patients who received SEV (SEV group). Forty-three patients were studied. Twenty-four of them received SEV. KYNA increased immediately after surgery and remained elevated through postoperative day 3 in the NonSEV group, whereas it was similar to the preoperative concentration in the SEV group. NLR increased immediately after surgery in both groups, and higher values were noted in the NonSEV group than in the SEV group at postoperative days 2 and 3. Plasma KYNA concentration correlated with NLR in the NonSEV group. Cardiac surgery caused an increase in NLR. Plasma KYNA increased in the NonSEV group and correlated with NLR. Administration of SEV inhibited the increase in KYNA, most likely due to its anti-inflammatory properties.

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Effects of anesthesia with sevoflurane on outcome parameters in murine experimental studies

Wrba,

Lupu,

Braumüller

et al. 2024

Eur J Trauma Emerg Surg

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Purpose Multiple murine studies modelling the immuno-pathophysiological consequences of trauma, shock, burn or sepsis were performed during the last decades. Almost every animal model requires anesthesia for practical and ethical reasons. Furthermore, often, corresponding control groups involve untreated animals without or with a limited exposure to anesthetics. However, the influences of anesthetic drugs on immuno-pathophysiological reactions remain insufficiently investigated. Therefore, we aimed to closer characterize the anesthetic impact exemplified by sevoflurane on the organ performance in mice and thereby investigate the influence of anesthesia itself on major outcome parameters in animal studies. Methods C57/BL6 mice were subjected either to 270 min of sevoflurane narcosis or directly euthanized. Plasma, BAL-fluids, lungs, kidneys, liver and intestine were collected and examined for immunological, functional and morphological changes. Results Systemic levels of the cytokine keratinocyte chemoattractant (KC) were raised in the narcosis group, while concentrations of high mobility group box protein 1 (HMGB-1) as a major inflammatory marker were reduced. In the lungs, levels of HMGB-1 and interleukin 6 (IL-6) were reduced. In contrast, systemic concentrations of intestinal fatty acid binding-protein (i-FABP) as an intestinal damage marker were elevated. Furthermore, liver-type fatty acid binding-protein (L-FABP) levels were lower in the narcosis animals, and inflammatory markers were reduced in liver tissues. Anesthesia also ameliorated the inflammatory reaction in renal tissues, while plasma levels of urea and creatinine were elevated, reflecting either dehydration and/or impaired renal function. Conclusion As anesthesia with sevoflurane exhibited distinct effects in different organs, it is difficult to predict its specific impact on targets of interest in in vivo studies. Therefore, further studies are required to clarify the effects of different anesthetic drugs. Overall, the inclusion of a control group subjected to the same anesthesia protocol as the experimental groups of interest seems helpful to precisely define the inherent impact of the anesthetic when investigating immuno-pathophysiologic conditions in vivo.

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Preventive effects of sevoflurane treatment on lung inflammation in rats

Abstract: Sevoflurane treatment can attenuate lung inflammation in rats with lipopolysaccharide-induced acute lung injury.

Cited by 14 publications

References 10 publications

Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

Analysis of the imflammatory effects of sevoflurane and izofluran on healty rat lung

Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

Effects of anesthesia with sevoflurane on outcome parameters in murine experimental studies

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