Preventive effects of oral administration of Nigella sativa oil against smokeless tobacco induced toxicity and oxidative stress in the liver and kidney of allergic asthma induced rats

Khaldi, Taha; Chekchaki, N.; Rouibah, Zineb; Chouala, Khadidja; Cheniti, Houyem; Boumendjel, Mahieddine; Taibi, Faiza; Messarah, Mahfoud; Boumendjel, Amel

doi:10.1007/s13530-022-00142-9

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…According to the study’s findings, the OVA group had significantly higher serum levels of AST and ALT and lower levels of total proteins and albumin than the control group. These results are consistent with previous investigations where OVA challenge led to higher AST and ALT levels and decreased levels of albumin and total proteins [ 34 ]. This rise in AST and ALT levels has been used as a sign of the severity of asthma, and it has been linked to the inadequate exchange of gases, which leads to hepatic oxygen deficiency and hepatocyte destruction [ 35 ].…”

Section: Discussionsupporting

confidence: 93%

“…In the current study, kidney damage was shown by a significant rise in creatinine, urea, and uric acid in the mice that were given OVA compared to the control group. These findings align with previous research where the OVA challenge resulted in greater creatinine, uric acid, and urea concentrations [ 34 ]. It is possible to explain this increase in creatinine, urea, and uric acid due to the inflammatory response that can result in renal injury and dysfunction [ 37 ].…”

Section: Discussionsupporting

confidence: 92%

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Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway

Abdelmawgood,

Mahana,

Badr

et al. 2023

Marine Drugs

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Asthma is a persistent inflammatory disease of the bronchi characterized by oxidative stress, airway remodeling, and inflammation. Echinochrome (Ech) is a dark-red pigment with antioxidant and anti-inflammatory activities. In this research, we aimed to investigate the effects of Ech against asthma-induced inflammation, oxidative stress, and histopathological alterations in the spleen, liver, and kidney in mice. Mice were divided into four groups (n = 8 for each): control, asthmatic, and asthmatic mice treated intraperitoneally with 0.1 and 1 mg/kg of Ech. In vitro, findings confirmed the antioxidant and anti-inflammatory activities of Ech. Ech showed antiasthmatic effects by lowering the serum levels of immunoglobulin E (IgE), interleukin 4 (IL-4), and interleukin 1β (IL-1β). It attenuated oxidative stress by lowering malondialdehyde (MDA) and nitric oxide (NO) contents and increasing reduced glutathione (GSH), superoxide dismutase (SOD), glutathione-s-transferase (GST), and catalase (CAT) in the liver, spleen, and kidney. Moreover, it protected asthma-induced kidney and liver functions by increasing total protein and albumin and decreasing aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, and uric acid levels. Additionally, it ameliorated histopathological abnormalities in the lung, liver, spleen, and kidney. Additionally, molecular docking studies were used to examine the interactions between Ech and Kelch-like ECH-associated protein 1 (Keap1). PCR and Western blot analyses confirmed the association of Ech with Keap1 and, consequently, the regulatory role of Ech in the Keap1-(nuclear factor erythroid 2-related factor 2) Nrf2 signaling pathway in the liver, spleen, and kidney. According to our findings, Ech prevented asthma and its complications in the spleen, liver, and kidney. Inhibition of inflammation and oxidative stress are two of echinochrome’s therapeutic actions in managing asthma by modulating the Keap1/Nrf2 signaling pathway.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway

Abdelmawgood,

Mahana,

Badr

et al. 2023

Marine Drugs

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“…87 Oxidation is not the only cause of cancer, but because it is considered the most important cause, various studies have been conducted on antioxidant compounds that show anti-cancer effects. 88–90…”

Section: Current Knowledge Of Medical Foodmentioning

confidence: 99%

The emerging role of medical foods and therapeutic potential of medical food-derived exosomes

Hur,

Lee,

Shin

et al. 2024

Nanoscale Adv.

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“…An additional parameter used to determine the antioxidant effect of the plant is protein carbonyl group content. The protein carbonyl group is more stable in the form of oxidized proteins than lipid peroxidation products [48]. Protein carbonyl content is the most common indicator and most commonly used marker of protein oxidation [49], and the accumulation of these compounds has been found in several human diseases (such as airway inflammation, oxidative lung injury, and Alzheimer's disease) [12].…”

Section: Discussionmentioning

confidence: 99%

In vivo determination of the anti-inflammatory and antioxidant effects of the aqueous extract of Syzygium aromaticum (clove) in an asthmatic rat model

Lynda Sabrina Ounaceur,

Mahfoud Messarah,

Abdelaziz Lankar

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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Asthma is a chronic inflammatory disease of the airways strongly associated with interleukin-4 (IL-4), a cytokine that mediates and regulates various immune responses, including allergic reactions. This study aimed to evaluate the anti-inflammatory and antioxidant effects of an Aqueous Extract of Clove (AEC) Syzygium aromaticum on the lungs and erythrocytes of an experimental asthma model in Wistar rats. For this purpose, four groups of male rats were examined: control, sensitized with ovalbumin (OVA), treated with AEC, and treated with a combination of OVA/AEC. After treatment, the antioxidant effect was determined by measuring the malondialdehyde (MDA), glutathione peroxidase (GPx), glutathione (GSH), and catalase (CAT) levels. The anti-inflammatory effect was determined by measuring IL-4 levels by performing enzyme-linked immunosorbent assay (ELISA) using serum, lung, and bronchoalveolar lavage fluid (BALF) samples. A significant reduction (p ≤ 0.05) in the MDA levels and a significant increase (p ≤ 0.05) in the levels of GPx and CAT were observed in the lungs of rats treated with cloves. However, no statistically significant variation was observed in GSH levels. In erythrocytes, no statistically significant differences were observed between the experimental batches. Regarding the anti-inflammatory effect, the administration of S. aromaticum extract to sensitized rats resulted in a recovery in the levels of total proteins and IL-4 and a decrease in the three compartments studied (lungs, serum, and bronchoalveolar liquid). These results were confirmed by microscopic examination of lung histological sections. Overall, these findings confirmed that the AEC has anti-inflammatory and antioxidant effects.

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Preventive effects of oral administration of Nigella sativa oil against smokeless tobacco induced toxicity and oxidative stress in the liver and kidney of allergic asthma induced rats

Cited by 6 publications

References 34 publications

Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway

Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway

The emerging role of medical foods and therapeutic potential of medical food-derived exosomes

In vivo determination of the anti-inflammatory and antioxidant effects of the aqueous extract of Syzygium aromaticum (clove) in an asthmatic rat model

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