Preventive effects of N-acetyl cysteine on lipids, lipoproteins and myocardial infarct size in isoproterenol induced myocardial infarcted rats: An in vivo and in vitro study

Meeran, Mohamed Fizur Nagoor; Prince, P. Stanely Mainzen; Basha, Rafeek Hidhayath

doi:10.1016/j.ejphar.2011.11.043

Cited by 39 publications

(20 citation statements)

References 23 publications

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“…This is in agreement with previous investigations (Nagoor Meeran et al, 2012;Abo-Gresha et al, 2014;Mahmoud et al, 2014). The observed increase in TC, TG and LDL-c levels in blood could initiate atherosclerosis with subsequent ischemic heart disease (Ferdinandy et al, 2007).…”

Section: Discussionsupporting

confidence: 93%

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Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Elhemely

Omar

Ain-Shoka

et al. 2014

Beni-Suef University Journal of Basic and Applied Sciences

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Hyperlipidemia Isoproterenol RosuvastatinEllagic acid a b s t r a c t Hyperlipidemia (HL) with subsequent coronary atherosclerosis is the major trigger of ischemia and hence, myocardial infarction (MI) occurs. The present study aimed to elucidate the effects of pretreatment with rosuvastatin and ellagic acid, as well as their combination on isoproterenol-induced MI in hyperlipidemic rats. Adult rats were fed with a cholesterol-rich diet for seven weeks and received rosuvastatin (10 mg/kg) and/or ellagic acid (30 mg/kg) by oral gavage daily starting from the fifth week then subcutaneously injected with two doses 24-h apart of 100 mg/kg isoproterenol in the last two days. ECG pattern was monitored and both cardiac biomarkers (cTnI, CK-MB, LDH and AST) and lipid profile (TC, TG, HDL-c and LDL-c) were measured in serum. MDA and GSH levels were quantified in cardiac homogenates and heart tissue damage was examined by histopathology. Furthermore, the expression levels of iNOS, eNOS, Bax and Bcl-2 in heart samples were assessed by western blotting. Three-week pretreatment with rosuvastatin and/or ellagic acid markedly ameliorated HL-and isoproterenol-induced alterations in ECG, cardiac markers, oxidation markers, lipid profile and heart architecture. Both drugs downregulated iNOS and upregulated eNOS, while only rosuvastatin and the combination downregulated Bax. This study provides evidence that rosuvastatin and ellagic acid possess cardioprotective effect on the hyperlipidemic-myocardial infarction rat model and the combination does not offer extra protection than monotherapy.

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Section: Discussionsupporting

confidence: 93%

“…However, isoproterenol, a synthetic catecholamine, liberates ROS and causes an infarct-like necrosis of the myocardium resembling MI in humans at toxic doses (Nagoor Meeran et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Elhemely

Omar

Ain-Shoka

et al. 2014

Beni-Suef University Journal of Basic and Applied Sciences

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“…Also, ISO induced MI is a well standardized and common model to study the protective effects of many drugs and cardiac function. The biochemical changes on ISO administration particularly altered lipid metabolism are comparable to those taking place in humans (Nagoor Meeran, Prince & Hidhayath Basha, 2012).…”

Section: Introductionmentioning

confidence: 67%

“…The observed excessive heart weight is due to increased water content, edematous intramuscular space and extensive necrosis of cardiac muscle fibers followed by invasion of the damaged tissues by inflammatory cells (Nagoor Meeran, Prince & Hidhayath Basha, 2012). Also, structural remodeling of components of the ventricular walls due to their adaptive response to physiological alterations due to ISO induced myocardial damage is another reason for cardiac hypertrophy (Roy & Prince, 2013b).…”

Section: Discussionmentioning

confidence: 98%

“…Myocardial ischemia occurs when myocardial oxygen demand surpasses oxygen supply and as a result it causes cell injury known as MI, which is one of the deadliest reflections of cardiovascular diseases (CVDs). The animal model of MI plays an important role in the prevention, diagnosis and therapy of human MI (Nagoor Meeran, Prince, & Hidhayath Basha, 2012). Isoproterenol (ISO) is a synthetic catecholamine and β-adrenergic agonist in rats, given its efficacy, workability, reliability and lower mortality and morbidity of animals (Roy & Prince, 2013b).…”

Section: Introductionmentioning

confidence: 99%

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Thymol attenuates altered lipid metabolism in β-adrenergic agonist induced myocardial infarcted rats by inhibiting tachycardia, altered electrocardiogram, apoptosis and cardiac hypertrophy

Meeran

Jagadeesh

Selvaraj

2015

Journal of Functional Foods

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Protective Effects of 7‐Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol‐Induced Myocardial Infarction in Rats

Jagadeesh

Meeran

Selvaraj

2015

J Biochem & Molecular Tox

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This study evaluates the protective effects of 7-hydroxycoumarin (7-HC) on dyslipidemia and cardiac hypertrophy in isoproterenol (ISO) induced myocardial infarction (MI) in rats. Rats were pre- and co treated with 7-HC (16 mg/kg) daily for 8 days. ISO (100 mg/kg) was subcutaneously injected into rats on seventh and eighth days to induce MI. Increased activity/levels of serum creatine kinase-MB (CK-MB), troponin-T, plasma lipid peroxidation products, and altered levels of lipids in the serum and heart and serum lipoproteins were noted in ISO-induced rats. ISO-induced myocardial infarcted rats revealed increased hypertrophy (cardiac and left ventricular) and hepatic 3-hydroxyl 3-methylglutaryl-coenzyme-A reductase (HMG-CoA reductase) activity. Pre and cotreatment with 7-HC revealed significant protective effects on all the biochemical parameters evaluated. The in vitro study demonstrated its free radical scavenging property. Thus, 7-HC protects ISO-induced MI in rats by its free radical scavenging and antihyperlipidaemic and antihypertrophic properties.

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Preventive effects of N-acetyl cysteine on lipids, lipoproteins and myocardial infarct size in isoproterenol induced myocardial infarcted rats: An in vivo and in vitro study

Cited by 39 publications

References 23 publications

Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats

Thymol attenuates altered lipid metabolism in β-adrenergic agonist induced myocardial infarcted rats by inhibiting tachycardia, altered electrocardiogram, apoptosis and cardiac hypertrophy

Protective Effects of 7‐Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol‐Induced Myocardial Infarction in Rats

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