Preventive Effects of<i>Houttuynia cordata</i>Extract for Oral Infectious Diseases

Sekita, Yasuko; Murakami, Keiji; Yumoto, Hiromichi; Amoh, Takashi; Fujiwara, Naofumi; Shohei, Ogata; Matsuo, Takashi; Miyake, Yoichiro; Kashiwada, Yoshiki

doi:10.1155/2016/2581876

Cited by 25 publications

(13 citation statements)

References 40 publications

(44 reference statements)

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“…However, it has been suggested that the use of organic extracts that include ethanol for oral care increases the risks of adverse reactions [ 35 ]. Therefore, a water solution of HC poultice ethanol extract (wHCP) used in our study may be safer than the ethanol based extract (eHCP) [ 36 ]. Our study has examined the properties of dHC, which is simpler to prepare than wHCP and has been used as health-promoting herbal tea without any reported adverse reactions from our interview survey [ 34 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a water solution of HC poultice ethanol extract (wHCP) used in our study may be safer than the ethanol based extract (eHCP) [ 36 ]. Our study has examined the properties of dHC, which is simpler to prepare than wHCP and has been used as health-promoting herbal tea without any reported adverse reactions from our interview survey [ 34 , 36 ]. Previous studies have demonstrated that medicinal plants also exert antiadherence effects against oral microorganisms [ 27 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fortunately, we have also shown that a water solution of eHCP (wHCP) exhibits antimicrobial and antibiofilm effects on oral microorganisms and anti-inflammatory effects on oral keratinocytes [ 36 ]. A decoction of dried HC leaves (dHC), commonly consumed as a health-promoting herbal tea in Japan, is simpler to prepare than wHCP.…”

Section: Introductionmentioning

confidence: 99%

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Antibiofilm and Anti‐Inflammatory Activities of Houttuynia cordata Decoction for Oral Care

Sekita

Murakami

Yumoto

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. Houttuynia cordata (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract (wHCP) exerts antimicrobial and antibiofilm effects against several important oral pathogens. It also exhibits anti-inflammatory effects on human keratinocytes. In our current study, we examined the effects of dHC on infectious oral pathogens and inflammation. Our results demonstrated that dHC exerts moderate antimicrobial effects against methicillin-resistant Staphylococcus aureus (MRSA) and other oral microorganisms. dHC also exhibited antibiofilm effects against MRSA, Fusobacterium nucleatum (involved in dental plaque formation), and Candida albicans and inhibitory effects on interleukin-8, CCL20, IP-10, and GROα productions by human oral keratinocytes stimulated by Porphyromonas gingivalis lipopolysaccharide (a cause of periodontal disease), without cytotoxic effects. This suggests that dHC exhibits multiple activities in microorganisms and host cells. dHC can be easily prepared and may be effective in preventing infectious oral diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Antibiofilm and Anti‐Inflammatory Activities of Houttuynia cordata Decoction for Oral Care

Sekita

Murakami

Yumoto

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…To address this issue, traditional Chinese medicine (TCM) has gradually been used as a substitute therapy with minimal relatively mild side effects. Houttuynia cordata has been shown to prevent oral infectious diseases [5] . Gynostemma pentaphyllum and total glucosides of paeony have been used as treatments for oral lichen planus [6] .…”

Section: Introductionmentioning

confidence: 99%

Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression

et al. 2017

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Chronic periodontitis (CP) is one of the most common oral diseases, which causes alveolar bone absorption and tooth loss in adults. In this study we aimed to investigate the potential of plumbagin (PL), a widely-investigated active compound extracted from the traditional Chinese herb Plumbago zeylanica L in treating CP. Human periodontal ligament stem cells (PDLSCs) were used for in vitro studies, whereas an animal model of CP was established in SD rats by ligation+Porphyromonas gingivalis (Pg) stimulation. The rats were injected with PL (2, 4, and 6 mg·kg·d, ip) for 4 weeks. Treatment of PDLSCs with TNF-α (10 ng/mL) markedly stimulated the expression of the proinflammatory cytokines TNF-α, IL-1β and IL-6, as well as the chemokines CCL-2 and CCL-5, which were dose-dependently suppressed by co-treatment with PL (1.25-5 μmol/L). Furthermore, PL (3.75 μmol/L) markedly suppressed TNF-α-induced activation of the MAPK, NF-κB and JAK/STAT signaling pathways in PDLSCs. In consistence with the in vitro studies, PL administration significantly decreased the expression of TNF-α, IL-1β and IL-6 in gingiva of the rat with CP, with the dosage 4 mg·kg·d showing the best anti-inflammatory effect. Moreover, PL administration decelerated bone destruction in the rat with CP, evidenced by the aveolar bone loss (ABL) and H&E staining results. In conclusion, PL suppresses CP progression in rats by downregulating the expressions of TNF-α, IL-1β and IL-6 and inhibiting the MAPK, NF-κB and JAK/STAT signaling pathways.

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“…Dental plaque is a multifaceted biofilm that builds up on the surface of teeth, including more than 500 bacterial species. Moreover, it has recently been shown that oral microorganisms can cause other severe or chronic infectious diseases (2,3). The value of mouth and teeth hygiene has been known from ancient times until now.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of a Herbal Mouthwash Containing Oak Husk of Quercus brantii and Zataria multiflora

Alipour

Dehshahri

Afsari

2018

Jundishapur J Nat Pharm Prod

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Background: Considering increasing antibiotic resistance and periodontal diseases incidence, the need of a safe, effective, and economical alternative mouthwash seems necessary. Combination of Persian oak husk of Quercus brantii (Jaft) with astringent and antibacterial properties of its tannins and Zataria multiflora leaves with anti-bacterial activity related to its essential oil seems to be more effective. Objectives: The aim of the present study was to prepare and evaluate a herbal mouthwash formulation containing the extract of Oak husk and essential oil of Zataria multiflora. Methods: The essential oil of Zataria multiflora leaves was obtained by hydro-distillation. Oak husk powder of Quercus brantii was extracted by infusion and then the extract was freeze-dried. Determination of tannin amount in the extract was performed by the Folin-Denis method. The essential oil analysis was performed by GC/MS. Formulations were prepared at five different concentrations of tannin (0.1%, 0.2%, 0.5%, 1%, and 2%) with 0.15% v/v of essential oil in the base of polyethylene glycol 400 and propylene glycol. The selected formulations were subjected to screening against Candida albicans, Lactobacillus acidophilus, Staphylococcus aureus, and Streptococcus mutans, using standard protocol of cell viability in comparison to the Persica mouthwash. Stability tests, such as tannin assay and pH, were done on days zero and forty-five after preparation of the formulations. Results and Conclusions: The best formulations with 0.2% and 0.5% of tannin, which were more stable and showed significantly more antibacterial effects than Persica mouthwash may be safe and effective for future clinical studies.

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Preventive Effects ofHouttuynia cordataExtract for Oral Infectious Diseases

Cited by 25 publications

References 40 publications

Antibiofilm and Anti‐Inflammatory Activities of Houttuynia cordata Decoction for Oral Care

Antibiofilm and Anti‐Inflammatory Activities of Houttuynia cordata Decoction for Oral Care

Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression

Preparation and Evaluation of a Herbal Mouthwash Containing Oak Husk of Quercus brantii and Zataria multiflora

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