Preventive Effects of Egyptian Sweet Marjoram (Origanum majorana L.) Leaves on Haematological Changes and Cardiotoxicity in Isoproterenol-Treated Albino Rats

Ramadan, Gamal; El-Beih, Nadia M.; Arafa, Nadia M. S.; Zahra, Mai M.

doi:10.1007/s12012-012-9189-4

Cited by 18 publications

(13 citation statements)

References 33 publications

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“…Leave powder and extract significantly alleviated erythrocytosis, granulocytosis, thrombocytosis, increase heart weight, and myocardial infarction oxidative stress in isoproterenol treated albino rats. 41 Essential oil of sweet marjoram depleted serum marker enzymes and replenished antioxidant status in hepatic of rat. 10…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Sweet Marjoram

Bina

Rahimi

2016

J Evid Based Complementary Altern Med

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Origanum majorana L. commonly known as sweet marjoram has been used for variety of diseases in traditional and folklore medicines, including gastrointestinal, ocular, nasopharyngeal, respiratory, cardiac, rheumatologic, and neurological disorders. Essential oil containing monoterpene hydrocarbons and oxygenated monoterpenes as well as phenolic compounds are chemical constituents isolated and detected in O majorana Wide range of pharmacological activities including antioxidant, hepatoprotective, cardioprotective, anti-platelet, gastroprotective, antibacterial and antifungal, antiprotozoal, antiatherosclerosis, anti-inflammatory, antimetastatic, antitumor, antiulcer, and anticholinesterase inhibitory activities have been reported from this plant in modern medicine. This article summarizes comprehensive information concerning traditional uses, phytochemistry, and pharmacological activities of sweet marjoram.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Sweet Marjoram

Bina

Rahimi

2016

J Evid Based Complementary Altern Med

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“…On the other hand, recent studies have confirmed the anti-proliferative effects of several plants such as Althaea officinalis (32,33) , Glycyrrhiza glabra L. (34,35,36) , Echium amoenum (37,38,39) , Origanum majorana (40,41) and Viola odorata (42,43,44) on viruses. Furthermore, these studies reported the antioxidant properties of Althaea officinalis (32,33) , Glycyrrhiza glabra (9,34,35,36) , Matricaria chamomilla (45,46,47) and mint (48) , the repairing effect of Althaea officinalis (32,33) and Malva sylvestris (49,50,51) and also the positive effect of Matricaria chamomilla (45,46,47) and cheese in strengthening the immune system.…”

Section: • Strengthen the Lungs And Other Involved Organsmentioning

confidence: 94%

Identifying Appropriate Therapeutic Methods in Covid-19 Originated from Persian Medicine: A Review Article

Maryam Monfared,

Mahdieh Eftekhari,

Samin Amini

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Objectives: COVID-19, a novel Coronavirus from same family as SARS-CoV-2 is a highly contagious virus. It is transmitted mainly from upper respiratory system and affects important organs, like heart and lungs. The aim of this study is identifying appropriate therapeutic methods originated from persian medicine. Materials and Methods: This study has been designed from the viewpoints of traditional and modern medicine. Considering modern medicine, we searched valid database by searching key words "SARS-Cov-2" and "COVID-19". For traditional medicine, we searched reliable traditional medicine like the "Canon of Medicine" by "Avicenna", the Exir-e Aazam and Zakhira-I Kharazm Shahi. Patients were evaluated according to their symptoms and categorized based on traditional medicine. Physiopathology and management of the disease, including prevention and treatment were studied. Results: The principle underlying mechanism seems to be warm and dry dystemperament that affects different organs and causes various adverse effects which are higher than warm and dry dystemperament, but less than the presence of virus. Our traditional Iranian medicine findings are validated by the modern medicine. Conclusion: Based on symptoms, the equivalent of this disease was examined from the viewpoint of traditional medicine. Then, physiopathology and management of this disease were presented in five levels, including one stage of prevention and four stages of treatment, and finally, the treatment recommendations of Iranian traditional medicine were approved with new research results.

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“…74. Egyptian sweet marjoram (Origanum majorana) leaf powder and marjoram leaf aqueous extract significantly reduced erythrocytosis, granulocytosis, thrombocytosis, shortened clotting time, decrease in relative heart weight, myocardial oxidative stress and the leakage of heart enzymes (creatine phosphokinase, creatine phosphokinase-MB isoenzyme, lactate dehydrogenase, and aminotransferase) in isoproterenol treated rats through reactivating non-enzymatic (reduced glutathione) and enzymatic (catalase, glutathione peroxidase, glutathione S-transferase, and superoxide dismutase) antioxidant defense system and inhibiting the production of nitric oxide and lipid peroxidation in heart tissues [82]. 75.…”

Section: Pretreatment Of Hydroalcoholic Extract Of Ocimum Canummentioning

confidence: 99%

Current Pharmacological Status of Cardioprotective Plants Against Isoproterenol Induced Myocardial Infarction

Fathima

S²

2018

Asian J Pharm Clin Res

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Objective: Cardiovascular diseases are the major cause of morbidity and mortality in the modern era. Myocardial infarction is a condition where there is a significant decrease or block in the blood (oxygen) supply to the part of heart, leading to degeneration of a portion of the myocardium which triggers a cascade of cellular, inflammatory and biochemical events, leading eventually to the irreversible death (necrosis) of heart muscle cells. Various therapeutic interventions, including lifestyle modification, pharmacological treatment options, and surgical techniques are available. The present review focus on the plants that have been evaluated for cardioprotective activity against isoproterenol-induced myocardial infarction.Method: The current status of Cardioprotective plants was obtained from a literature search of electronic databases such as Google Scholar, Pubmed and Scopus up to 2017 for publications on medicinal plants used against isoproterenol-induced myocardial infarction. Isoproterenol, Isoprenaline, myocardial infarction, cardioprotective were used as keywords for the searching.Result: A total of 117 different plant parts and their extracts have till now been published to possess cardioprotection against isoproterenol-induced myocardial infarction. Isoproterenol a beta-adrenergic receptors agonist causes severe stress in myocardium resulting in the infarct-like lesion and produced cardiotoxic effects by elevating the levels of cardiac biomarkers and causing changes in ECG. Plant-based medicines with their antioxidant, antiapoptotic, antihyperlipidemic, platelet antiaggregatory, anti-lipid peroxidation property provide substantial evidence for the management of Ischemia.Conclusion: This review, therefore, provides a useful resource to enable a thorough assessment of the profile of plants that have cardioprotective activity against isoproterenol-induced myocardial infarction.

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Preventive Effects of Egyptian Sweet Marjoram (Origanum majorana L.) Leaves on Haematological Changes and Cardiotoxicity in Isoproterenol-Treated Albino Rats

Cited by 18 publications

References 33 publications

Sweet Marjoram

Sweet Marjoram

Identifying Appropriate Therapeutic Methods in Covid-19 Originated from Persian Medicine: A Review Article

Current Pharmacological Status of Cardioprotective Plants Against Isoproterenol Induced Myocardial Infarction

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