Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats

Kömürcü, Erkam; Oktay, Murat; Kaymaz, Burak; Gölge, Umut Hatay; Göksel, Ferdi; Nusran, Gürdal

doi:10.3944/aott.2014.13.0150

Cited by 13 publications

(5 citation statements)

References 19 publications

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“…The toll-like receptor 4 (TLR4) pathway was implicated in SONFH by Okazaki et al [48] and Tian et al [49], who found that corticosteroids SONFH by disturbing the immune response via TLR4 signaling pathway. Subsequently, Erkam Komurcu et al [50] and Miyata et al [51] found that coenzyme Q10 prevented SONFH by reducing oxidative stress. Pentosan, a semisynthetic polysulfated xylan appears to reduce the incidence of ONFH in SHRSP by improving lipid metabolism and decreasing oxidative stress.…”

Section: Ratmentioning

confidence: 99%

Animal models of steroid-induced osteonecrosis of the femoral head—a comprehensive research review up to 2018

Gong

et al. 2018

International Orthopaedics (SICOT)

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Osteonecrosis of the femoral head (ONFH) is a significant cause of both pain and disability that often affects young adults during what ought to be their most productive age. Two broad categories of ONFH exist: traumatic and non-traumatic. Traumatic ONFH results from acute mechanical disruption of the femoral head's blood supply. Many factors that increase the risk of non-traumatic osteonecrosis have been identified. Steroid-induced osteonecrosis of the femoral head (SONFH) is the most common form of non-traumatic ONFH. Many hypotheses as to the pathogenesis of SONFH have been proposed, including intravascular thrombosis, abnormal fat metabolism, intramedullary adipocyte hypertrophy, and osteoporosis; however, the exact mechanism of SONFH is still not clearly understood. Animal models using rats, mice, rabbits, chickens, pigs, and emus have been used to study SONFH. Unfortunately, these models each have limitations. Therefore, it is necessary to establish a reproducible model that better simulates human disease. The present review is intended to summarize the currently available models, evaluative indicators, and application of current understanding to both the prevention and treatment of SONFH.

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Section: Ratmentioning

confidence: 99%

Animal models of steroid-induced osteonecrosis of the femoral head—a comprehensive research review up to 2018

Gong

et al. 2018

International Orthopaedics (SICOT)

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“…3,4 Many antioxidants have proven to be effective correspondence: Qiugen Wang Trauma center, shanghai general hospital, shanghai Jiaotong University school of Medicine, 650 Xin songjiang road, shanghai 201620, china Tel +86 1 331 198 6527 email wangqiugen@126.com in therapy for steroid-induced osteonecrosis in rat models. 5,6 It is reported that selenium (Se), an essential micronutrient in humans and animals with a wide range of biologic functions, 7 could suppress oxidative stress and serves as a reactive oxygen species (ROS) scavenger. [8][9][10][11] In some cases, a deficiency of Se could induce oxidative stress and endoplasmic reticulum stress.…”

Section: Introductionmentioning

confidence: 99%

Porous Se@SiO<sub>2</sub> nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis

Deng¹,

Dai²,

Jin-yuan³

et al. 2018

IJN

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BackgroundMethylprednisolone (MPS) is an important drug used in therapy of many diseases. However, osteonecrosis of the femoral head is a serious damage in the MPS treatment. Thus, it is imperative to develop new drugs to prevent the serious side effect of MPS.MethodsThe potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1β and TNF-α. And oxidative stress species (ROS) index like superoxide dismutase (SOD) and glutathione (GSH) were tested. Then, the protection effects of Se@SiO2 have in osteonecrosis of the femoral head (ONFH) were evaluated by micro CT, histologic analysis and Western-blot analysis.ResultsIn the present study, we found that in the rat model of ARDS, Se@SiO2 nanocomposites induced SOD and GSH indirectly to reduce ROS damage. The wet-to-dry weight ratio of lung was significantly decreased after MPS treatment compared with the control group, whereas the Se@SiO2 did not affect the reduced wet-to-dry weight ratio of MPS. Se@SiO2 also did not impair the effect of MPS on the reduction of inflammatory factors IL-1β and TNF-α, and on the alleviation of structural destruction. Furthermore, micro CT and histologic analysis confirmed that Se@SiO2 significantly alleviate MPS-induced destruction of femoral head. Moreover, compared with MPS group, Se@SiO2 could increase collagen II and aggrecan, and reduce the IL-1β level in the cartilage of femoral head. In addition, the biosafety of Se@SiO2 in vitro and in vivo were supported by cell proliferation assay and histologic analysis of main organs from rat models.ConclusionSe@SiO2 nanocomposites have a protective effect in MPS-induced ONFH without influence on the therapeutic activity of MPS, suggesting the potential as effective drugs to avoid ONFH in MPS therapy.

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“…In addition, it has been hypothesized that osteonecrosis is produced by the ischemic change accompanying the compartment pressure load in the marrow, where degeneration and necrosis may occur simultaneously with oxidative stress16. Besides, antioxidants such as Coenzyme Q10 (CoQ10)17 and hydrogen-rich saline18, have already been proved to be therapeutic for steroid-induced osteonecrosis in rats. While stem cell factor (SCF)19 and grape seed proanthocyanidin proved protective by reducing oxidative stress20.…”

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confidence: 99%

Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species

Deng

Niu

Zhou

et al. 2017

Sci Rep

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Reducing oxidative stress (ROS) have been demonstrated effective for steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH). Selenium (Se) plays an important role in suppressing oxidative stress and has huge potential in ONFH treatments. However the Se has a narrow margin between beneficial and toxic effects which make it hard for therapy use in vivo. In order to make the deficiency up, a control release of Se (Se@SiO2) were realized by nanotechnology modification. Porous Se@SiO2 nanocomposites have favorable biocompatibility and can reduced the ROS damage effectively. In vitro, the cck-8 analysis, terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) stain and flow cytometry analysis showed rare negative influence by porous Se@SiO2 nanocomposites but significantly protective effect against H2O2 by reducing ROS level (detected by DCFH-DA). In vivo, the biosafety of porous Se@SiO2 nanocomposites were confirmed by the serum biochemistry, the ROS level in serum were significantly reduced and the curative effect were confirmed by Micro CT scan, serum Elisa assay (inflammatory factors), Western blotting (quantitative measurement of ONFH) and HE staining. It is expected that the porous Se@SiO2 nanocomposites may prevent steroid-induced ONFH by reducing oxidative stress.

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Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats

Abstract: Coenzyme Q10 may be useful as a preventing agent in steroid-induced ONFH. Inhibited oxidative stress is a possible mechanism for this effect.

Cited by 13 publications

References 19 publications

Animal models of steroid-induced osteonecrosis of the femoral head—a comprehensive research review up to 2018

Animal models of steroid-induced osteonecrosis of the femoral head—a comprehensive research review up to 2018

Porous Se@SiO<sub>2</sub> nanocomposites protect the femoral head from methylprednisolone-induced osteonecrosis

Treatment of steroid-induced osteonecrosis of the femoral head using porous Se@SiO2 nanocomposites to suppress reactive oxygen species

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