Preventive effects of an original combination of grape seed polyphenols with amine fluoride on dental biofilm formation and oxidative damage by oral bacteria

Furiga, Aurélie; Roques, Christine; Badet, Cécile

doi:10.1111/jam.12395

Cited by 39 publications

(65 citation statements)

References 44 publications

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“…The general impact of plant extracts on dental erosion has also been investigated rather sparsely. Most studies on these compounds focus on the oral biofilm; many of them are pure in vitro studies [Percival et al, 2006;Hannig et al, 2008bHannig et al, , 2009bTomczyk et al, 2013;Furiga et al, 2014;Giacaman et al, 2014;Girardot et al, 2014;Kong et al, 2014;Riihinen et al, 2014]. The present experimental in situ study found for the first time that a combination of wild Origanum and wild R. nigrum leaves has the potential to improve the protective properties of the pellicle against erosive noxae.…”

Section: Discussionmentioning

confidence: 66%

Application of Plant Extracts for the Prevention of Dental Erosion: An in situ/in vitro Study

et al. 2015

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Objectives: Antiadherent and antibacterial effects of certain plant extracts have been proven to be beneficial in preventive dentistry. In the present in situ/in vitro crossover study, the impact of plant extracts rich in polyphenols on the erosion-protective properties of the in situ pellicle was evaluated. Methods: Individual splints were prepared for 12 subjects for intraoral exposure of bovine enamel specimens. Following formation of a 1-min pellicle, watery plant extracts (leaves of the wild form of Ribes nigrum, the wild form of Origanum as well as a combination of both) were administered for 10 min in situ. Alternatively, a mouth rinse with fluorides (Elmex Kariesschutz) was performed for 1 min. After further oral exposure for 19/28 min, respectively, slabs were removed and incubated with HCl in vitro over 120 s (pH 2, 2.3, 3). The resulting calcium and phosphate release was quantified photometrically. Slabs with and without a 30-min in situ pellicle served as controls. The modification of pellicle ultrastructure was evaluated by transmission electron microscopy (TEM). Results: Plant extracts modulated the erosion-protective properties of the native in situ pellicle in all test groups in a pH-dependent manner. The combination of R. nigrum leaves and Origanum enhanced the protective properties of the pellicle at all pH values; the administration of this preparation was comparable, yet superior, to the effect of the fluoridated mouth rinse. TEM images indicated that rinsing with R. nigrum leaves/Origanum yielded a distinctly thicker and more electron-dense pellicle. Conclusion: The combination of certain plant extracts offers a novel approach to the complementary prevention of dental erosion.

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Section: Discussionmentioning

confidence: 66%

Application of Plant Extracts for the Prevention of Dental Erosion: An in situ/in vitro Study

et al. 2015

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“…The combination of GSE with fluoride showed both significant antiplaque activities and antioxidant properties. The results indicated that the antibiofilm activity of the combination of 2,000 μg/ml of GSE with 10.2 mg/ml of Fluorinol ® was greater than that of each compound tested alone [Furiga et al, 2014]. Grape phenolic extracts could be maintained in the wine and keep the ability to inhibit bacteria.…”

Section: Grapesmentioning

confidence: 71%

Natural Products and Caries Prevention

Cheng

et al. 2015

Caries Res

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Dental caries is considered as the most common polymicrobial oral disease in the world. With the aim of developing alternative approaches to reduce or prevent the decay, numerous papers showed the potential anticaries activity of a number of natural products. The natural products with anticaries effects are selected from e.g. food, beverages, flowers or traditional herbs. Most of the effective components are proven to be polyphenol compounds. Many of the natural products are studied as antibacterial agents, while some of them are found to be effective in shifting the de-/remineralization balance. However, the mechanisms of the anticaries effects are still unclear for most of the natural products. In the future, more efforts need to be made to seek novel effective natural products via in vitro experiment, animal study and in situ investigations, as well as to enhance their anticaries effects with the help of novel technology like nanotechnology.

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“…; Furiga et al . ). Over 70% of the therapeutic agents developed between 1981 and 2003 for infectious diseases were derived from natural products (Newman et al .…”

Section: Introductionmentioning

confidence: 97%

Identification of anti-biofilm components in Withania somnifera and their effect on virulence of Streptococcus mutans biofilms

et al. 2015

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Preventive effects of an original combination of grape seed polyphenols with amine fluoride on dental biofilm formation and oxidative damage by oral bacteria

Abstract: This is, to our knowledge, the first report on the properties of an original combination of a polyphenolic extract with amine fluoride that could be used for the prevention of oral diseases and oxidative damage associated.

Cited by 39 publications

References 44 publications

Application of Plant Extracts for the Prevention of Dental Erosion: An in situ/in vitro Study

Application of Plant Extracts for the Prevention of Dental Erosion: An in situ/in vitro Study

Natural Products and Caries Prevention

Identification of anti-biofilm components in Withania somnifera and their effect on virulence of Streptococcus mutans biofilms

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