Preventive effect of trimetazidine against ischemia-reperfusion injury in rat epigastric island flaps: an experimental study

Akdemır, Ovunc; Tatar, Burak Ergün; Gökhan, Aylin; Şirin, Cansın; Çavuşoğlu, Türker; Erbaş, Oytun; Uyanıkgil, Yiğit; Çetin, Emel Öykü; zhang, Feng; Lineaweaver, William C.

doi:10.1007/s00238-020-01757-2

Cited by 3 publications

(2 citation statements)

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“…Reperfusion sets off a cascade of acute inflammatory processes, resulting in cellular death and, therefore, tissue malfunction and necrosis (12). Regardless of a surgeon's skill, post-revascularization I/R damage is an unavoidable pathophysiological process (13). The majority of investigations on I/R damage have been done on rats (14-18), and thus rats have served as the model animal in a number of studies.…”

Section: Discussionmentioning

confidence: 99%

“…The short halflife of free oxygen radicals makes it difficult to show their existence. Since the quantity of MDA (the end product of lipid peroxidation in cells) increases in proportion to the free oxygen radicals in I/R damage, we employed MDA testing to quantify reperfusion injury (13). However, there were no significant changes between the edaravone group and the control group in terms of MDA levels.…”

Section: Discussionmentioning

confidence: 99%

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Preventive Effect of Edaravone Against Ischemia-Reperfusion Injury in Rat Epigastric Island Flaps: An Experimental Study

Akdemır¹,

Tatar²,

Uyanıkgil

et al. 2023

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Objective Ischemia-reperfusion (I/R) injury is tissue damage occurring when blood returns to a tissue after an ischemic phase. Reperfusion initiates a cascade of acute inflammatory processes that end in cell death, tissue malfunction, and necrosis. Edaravone (3-methy-1-pheny1-2-pyrazolin-5-one) is a powerful and unique synthetic radical scavenger. In this research, the effects of edaravone on I/R damage were investigated. Material and Methods: 16 adult male Sprague–Dawley rats were utilized. Eight rats were allocated at random into two groups. Group 1 (the control group) experienced ischemia and reperfusion of an abdominal skin flap for 10 hours without therapy. Group 2 (treatment group) received an intraperitoneal injection of 3 mg/kg edaravone 10 hours prior to ischemia and reperfusion in an abdominal skin flap. Using planimetry, flaps were examined at intervals of 1, 3, 7, and 10 days. Then, flaps were removed for biochemical (measurement of tissue glutathione [GSH], tissue protein, lipid peroxidation [MDA], and nitric oxide [NO] levels) and histopathological (measurement of tissue glutathione [GSH], tissue protein, lipid peroxidation [MDA], and nitric oxide [NO] levels) Results: We found no significant changes (p > 0.05) between groups 1 and 2 in terms of NO, MDA, GSH, or planimetric analyses. Group 2 had a lower neutrophil count than group 1, however the difference was not statistically significant (p > 0.05). Conclusion Edaravone is a very effective antioxidant. Nevertheless, our research indicates that it may not influence I/R damage in a skin flap model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%