Preventive effect of pomegranate juice against chemically induced bladder cancer: An experimental study

Mortada, Wael I.; Awadalla, Amira; Khater, Sherry M.; Barakat, Nashwa; Husseiny, Sherif M.; Shokeir, Ahmed A.

doi:10.1016/j.heliyon.2020.e05192

Cited by 12 publications

(10 citation statements)

References 53 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The next in vivo study confirmed the beneficial effect of pomegranate juice in reducing hyperplasia, dysplasia, and invasive neoplasms in the chemically induced ( N -butyl- N -(4-hydroxybutyl)-nitrosamine) BC rat model [ 69 ]. Rats with chemically induced BC were characterized by p53 expression impairment, while pomegranate juice treatment restored a regular p53 expression.…”

Section: Pomegranatementioning

confidence: 80%

“…A summary of the anticancer effects and mechanisms of pomegranate action is presented in Figure 1. cell proliferation [41], glycolysis [53][54][55], and cell cycle [59,60] as well as apoptosis [23,41,42,47,48,51,53,54,61,62,69,71]. The summary of anticancer effects and mechanisms of pomegranate action.…”

Section: Pomegranate In Bladder Cancer Preventionmentioning

confidence: 99%

“…In contrast, catalase, glutathione, and superoxide dismutase levels lowered in the cancer-induced group compared to control rats. However, pomegranate juice oral administration restored the normal status of oxidative stress markers [ 69 ]. Thus, the anticancer activity of pomegranate juice is also due to its high antioxidant activity [ 70 ].…”

Section: Pomegranatementioning

confidence: 99%

“…Therefore, the use of pomegranate juice is preferable to its ingredients separately. Mortada and colleagues also demonstrated the anti-inflammatory activity of pomegranate juice [ 69 ]. Rats with chemically induced BC were characterized by increased expression of IL-6 (interleukin 6), TNF-α (tumor necrosis factor-alpha), and HIF-1 (hypoxia-inducible factor-1) in bladder tissues [ 69 ].…”

Section: Pomegranatementioning

confidence: 99%

See 3 more Smart Citations

Clinical Potential of Fruit in Bladder Cancer Prevention and Treatment

2022

View full text Add to dashboard Cite

Bladder cancer (BC) is the most common tumor of the urinary system in the world. Moreover, despite using anticancer therapies, BC is also characterized by a high recurrence risk. Among numerous risk factors, cigarette smoking, occupational exposure to certain aromatic compounds, and genetic factors contribute most strongly to BC development. However, the epidemiological data to date suggests that diet quality may influence some carcinogenic factors of BC and, therefore, might have a preventative effect. Adequate consumption of selected fruits with scientifically proven properties, including pomegranates and cranberries, can significantly reduce the risk of developing BC, even in those at risk. Therefore, in this article, we aim to elucidate, using available literature, the role of fruits, including pomegranates, cranberries, citrus fruits, cactus pears, and apples, in BC prevention and treatment. Previous data indicate the role of compounds in the above-mentioned fruits in the modulation of the signaling pathways, including cell proliferation, cell growth, cell survival, and cell death.

show abstract

Section: Pomegranatementioning

confidence: 80%

Section: Pomegranate In Bladder Cancer Preventionmentioning

confidence: 99%

Section: Pomegranatementioning

confidence: 99%

Section: Pomegranatementioning

confidence: 99%

See 2 more Smart Citations

Clinical Potential of Fruit in Bladder Cancer Prevention and Treatment

2022

View full text Add to dashboard Cite

show abstract

“…It can correct the expression of pro-inflammatory cytokines (interleukin 6 and hypoxia-inducible factor 1), it also press angiogenesis by downregulation of hypoxia-inducible factor and supports apoptosis through reduction of the tumor suppressor gene p53. Mortada et al (2020) n. Dwarf pomegranate extracts showed potent growth inhibitory activities in human prostate cancer cells (DU145), which appear to be mediated by a pro-apoptotic mechanism. reduced hs-CRP, IL-6, and TNF-α.…”

Section: Minaiyan Et Al (2014) Alzheimermentioning

confidence: 99%

Pomegranate, fruit of the desert, a functional food, and a healthy diet

2021

View full text Add to dashboard Cite

Traditional medicinal plants contain various ranges of chemical contents and they have become popular because of effectiveness, frequently inadequate provision of modern medicine, preferences and cultural beliefs. Pomegranate belongs to the family of Punicaceae, and its various pharmacological activities are due to presence of wide range of bioactive compounds. The current searching was done by the keywords in main indexing systems including PubMed/MEDLINE, Scopus, and Institute for Scientific Web of Science as well as the search engine of Google Scholar. The keywords were traditional medicine, health benefits, pharmaceutical science, pomegranate, punicalin, punicalagin, and ellagitannins. Major polyphenols in peel and juice of pomegranate are flavonoids such as flavonols (catechin, epicatechin, gallocatechin), condensed tannins, phenolic acids such as gallic, ellagic and caffeic, hyrolysable tannins such as ellagitannins and gallotannins. The main organic acids in pomegranate juice are malic and citric, and in seed is fatty acids (punicic). The major alkaloids and lignans in peel are punigratane and isolariciresinol, respectively. Pomegranate fruit has been proven to act against various diseases like cancer, cardiovascular disorders, diabetes, AIDS, Alzheimer’s disease, male infertility, inflammation, coronary heart disease, and aging. The review summarizes the beneficial impacts of pomegranate which is recommended for consumption. Pomegranate is a high potential natural functional food due to its high pharmacological activities as an ancient efficacious natural drug.

show abstract