Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells

TRPA1 is functionally expressed in melanoma cells but is not critical for impaired proliferation caused by allyl isothiocyanate or cinnamaldehyde

“…Melanoma in general are difficult to treat with traditional forms of chemotherapy and radiotherapy and, despite numerous efforts, current therapeutic options with immune therapy and vaccines are still not very effective (Eggermont et al 2009). Several studies have shown an anti-cancer effect of phytochemicals like cinnamaldehyde, the aromatic component of cinnamon, or isothiocyanates derived from cruciferous vegetables such as broccoli, cabbage and radish in melanoma models (Cabello et al 2009;Fuke et al 2006;Sharma et al 2008). The application of cinnamaldehyde, for example, has been shown to reduce the tumour burden in an A375 melanoma mouse xenograft model and to exert an anti-proliferative, apoptogenic and anti-invasive activity under cell culture conditions, without identifying the molecular correlate of its anti-tumour activity in melanoma cells (Cabello et al 2009).…”

Detection of 6-(Methylsulfinyl)hexyl Isothiocyanate (6-MITC) and Its Conjugate with N-Acetyl-L-cysteine (NAC) by High Performance Liquid Chromatograpy-Atmospheric Pressure Chemical Ionization Mass Spectrometry (HPLC-MS/APCI)

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Previous reports have documented that some isothiocyanates (ITCs) prevent the formation of cancers in animal models.1-4) 6-(Methylsulfinyl)hexyl isothiocyanate (6-MITC) is found in wasabi (Wasabia japonica), a Japanese indigenous herb, and a variety of studies on the anticancer properties of 6-MITC have been described, 5,6) with 6-MITC attracting great attention as a new possible candidate for controlling cancer cell progression and metastasis. Anticancer activity of 6-MITC in vitro was studied with a human cancer cell (HCC) panel and 6-MITC directly affected the cells in the HCC panel.

5) A suppression was found in the growth and survival of the cells in culture, and the affected cells were very specific, which included breast cancer and melanoma cell lines.

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“…[1][2][3][4] 6-(Methylsulfinyl)hexyl isothiocyanate (6-MITC) is found in wasabi (Wasabia japonica), a Japanese indigenous herb, and a variety of studies on the anticancer properties of 6-MITC have been described, 5,6) with 6-MITC attracting great attention as a new possible candidate for controlling cancer cell progression and metastasis. Anticancer activity of 6-MITC in vitro was studied with a human cancer cell (HCC) panel and 6-MITC directly affected the cells in the HCC panel.…”

Bioactive Food Components for Melanoma: An Overview

“…Other bioactive agents such as garlic extract [128], exo-biopolymer from rice bran [129], and isothiocyanates extract of wasabi [130], as well as flavonoids such as hesperitin, naringenin [131] and chrysin derived from acacia honey [132] have been evaluated for their cytotoxic effect on melanoma cells. A limited number of studies have been effectuated on these compounds with several of them appearing as potential agents against melanoma, but the exact knowledge regarding their active excipient as well as their mechanistic potentials requires extensive in vitro cell culture and in vivo animal model studies to elucidate.…”