Preventive Effect of L-Carnitine on the Disorder of Lipid Metabolism and Circadian Clock of Mice Subjected to Chronic Jet-Lag

Xie, Xiaoxian; Guo, Anqi; Wu, Tao; Hu, Qinglian; Huang, Liangfeng; Yao, Cencen; Zhao, Binggong; Chi, Bingbing; Lü, Ping; Zhao, Zhenzhen; Fu, Zhengwei

doi:10.33549/physiolres.933543

Cited by 9 publications

(5 citation statements)

References 43 publications

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“…7. ELISA hepatic profiles for lipid synthesis and catabolism in standard laboratory diet (SLD) and highfat diet (HFD) mice exposed to a normal (NL) or rotating light (RL) cycle including metabolic processes involved in glucose metabolism, known to be disrupted in chronic jet lag (30,59) and HFD conditions (17), which may also contribute to hepatic lipid accumulation.…”

Section: G937 Circadian Disruption Of Metabolismmentioning

confidence: 99%

A rotating light cycle promotes weight gain and hepatic lipid storage in mice

Christie

Vincent

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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Processes involved in regulation of energy balance and intermediary metabolism are aligned to the light-dark cycle. Shift-work and high fat diet (HFD)-induced obesity disrupt circadian rhythmicity and are associated with increased risk of non-alcoholic fatty liver disease (NAFLD). This study aimed to determine the effect of simulating shift work on hepatic lipid accumulation in lean and HFD-mice. C57BL/6 mice fed a standard laboratory diet (SLD) or HFD for 4wks were further allocated to a normal light (NL)-cycle (lights on:0600-1800hr) or rotating light (RL)-cycle (3-days NL and 4-days reversed (lights on:1800-0600hr) repeated) for 8wks. Tissue was collected every 3hrs beginning at 0600hr. HFD-mice gained more weight than SLD-mice, and RL-mice gained more weight than NL-mice. SLD-NL and HFD-NL mice, but not RL-mice, were more active, had higher respiratory quotients and consumed/expended more energy during the dark phase compared to the light phase. Blood glucose and plasma cholesterol and triglyceride concentrations were elevated in HFD and SLD-RL compared to SLD-NL mice. Hepatic glycogen was elevated in HFD compared to SLD-mice. Hepatic triglycerides were elevated in SLD-RL and HFD-mice compared to SLD-NL. Circadian rhythmicity of hepatic acetyl-CoA carboxylase (ACACA) mRNA was phase shifted in SLD-RL and HFD-NL and lost in HFD-RL mice. Hepatic ACACA protein was reduced in SLD-RL and HFD-mice compared to SLD-NL mice. Hepatic adipose triglyceride lipase was elevated in HFD-NL compared to SLD-NL but lower in RL-mice compared to NL-mice irrespective of diet. -Conclusion: A RL-cycle model of shift-work promotes weight gain and hepatic lipid storage even in lean conditions.

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Section: G937 Circadian Disruption Of Metabolismmentioning

confidence: 99%

A rotating light cycle promotes weight gain and hepatic lipid storage in mice

Christie

Vincent

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…10,21 We constructed a chronic shift-lag mouse model by subjecting mice to a reverse light-dark cycle every 4 days for 12 weeks. 23 Splenic NK cells were sorted by flow cytometry. Certain important molecules that regulate circadian rhythm, such as per1-3, Bmal1 and CLOCK, were examined by RT-qPCR and Western blotting.…”

Section: Discussionmentioning

confidence: 99%

Chronic shift‐lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122

Zeng

Liang²,

Yao

2020

J Cellular Molecular Medi

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Natural killers (NKs) are a type of innate immune cell that can directly kill tumour cells without pre-activation. It is well-known that NK cell-mediated immune monitoring not only kills tumour cells directly, but also indirectly releases cytokines to regulate other leucocytes such as macrophages, T cells and dendritic cells (DCs). 1 NK cells can destroy infected and tumour cells by releasing cytolytic granules and interferon gamma (IFN-γ). Among these molecular mechanisms, the release of granzyme B and perforin is the most effective way for NK cells to kill tumour cells. 2 Another important function of NK cells is the release of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α). 3 NK cells are derived from bone marrow and are tightly regulated by IL-15

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“…While few reports have focused on isobutyrylcarnitine by itself, a previous report demonstrated that carnitine—its liberated form—affected circadian rhythms through lipid metabolism and contributed to correcting a disturbed circadian rhythm [ 15 ]. As the levels of isobutyrylcarnitine decreased significantly in the nonresponders, the effect of a rice diet may have been canceled by the disruption of the circadian rhythm.…”

Section: Discussionmentioning

confidence: 99%

Impact of a Rice-Centered Diet on the Quality of Sleep in Association with Reduced Oxidative Stress: A Randomized, Open, Parallel-Group Clinical Trial

2020

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Previously, we found that a Japanese diet was associated with psychological status, and a combination of rice and miso was related to mental and physical health. We hypothesized that the intake of a rice-based diet affected mental and physical health and aimed to investigate the consequences of a dietary intervention with rice. We conducted a randomized, open-label, parallel-group clinical trial that included 60 participants, who were randomly assigned to receive either rice-based meals or meals with other cereals for three daily meals over 2 months. The participants were surveyed for psychological status and biochemical changes. Sleep quality index scores showed significant improvement after the rice-based intervention. Additionally, blood oxidative stress levels were reduced in the rice-diet group compared with the no-rice-diet group. Although the molecular mechanisms should be investigated in detail, our findings suggest that controlling oxidative stress through the intake of a rice-centered diet may be key to improving sleep quality.

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Preventive Effect of L-Carnitine on the Disorder of Lipid Metabolism and Circadian Clock of Mice Subjected to Chronic Jet-Lag

Cited by 9 publications

References 43 publications

A rotating light cycle promotes weight gain and hepatic lipid storage in mice

A rotating light cycle promotes weight gain and hepatic lipid storage in mice

Chronic shift‐lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122

Impact of a Rice-Centered Diet on the Quality of Sleep in Association with Reduced Oxidative Stress: A Randomized, Open, Parallel-Group Clinical Trial

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